IndraLab

Statements

IFNG increases the amount of OTUD5. 5 / 5
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"IFN-γ has been detected to upregulate the expression of OTUD5 through p38-dependent mechanism to amplify the aberrant inflammatory cytokine response in IBD (Dinallo et al., 2022)."
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"It has been found that IFN-γ stimulation increases OTUD5 expression in LPMC from patients with inflammatory bowel disease."
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"IFN-γ and IL-1β have been shown to upregulate and downregulate expression of DUBA, respectively."
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"Additionally, they examined the molecular mechanisms of DUBA expression and found that IFN-γ promotes the DUBA expression through p38/mitogen-activated protein kinase pathways."
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"OTUD5 expression was enhanced by IFN-gamma through a p38 and MAPK dependent mechanism and the AS induced knockdown of OTUD5 in LPMCs of IBD patients and colitic mice reduced TNF-alpha."
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