IndraLab

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UBR5 activates OTUD5. 2 / 2

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"UBR5 destabilizes DUBA through ubiquitylation, whereas DUBA stabilizes UBR5 in activated T cells by attenuating degradative auto-ubiquitylation, triggering UBR5 mediated ubiquitylation of the transcription factor RORyt in response to TGF-beta [XREF_BIBR]."

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"Considering other potential post-transcriptional mechanisms, we investigated the ubiquitin ligase UBR5, which has been reported to mediate OTUD5 abundance post-transcriptionally ."

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IndraLab

Statements

UBR5 activates OTUD5. 2 / 2

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