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OTUD5 activates TP53. 16 / 18
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"Accordingly, OTUD5 overexpression has been shown to effectively enhance the activation of PDCD5 and TP53."
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"This sequential interplay between OTUD5 and either PDCD5 or p53 was abolished by knockdown of either OTUD5 or PDCD5 ( Fig. 4B , second and third panel), suggesting that PDCD5 stabilization by OTUD5 pr[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"OTU deubiquitinase (OTUD5) binds to PDCD5inresponseto etoposide treatment and effectively mediates the sequential activation of both PDCD5 and P53."
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"The function of OTUD5 is required to allow the rapid activation of p53 dependent transcription and a p53 dependent apoptosis in response to DNA damage stress."
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"These data demonstrated that OTUD5 mediated sequential activation of PDCD5 and p53 in response to genotoxic stress.We further validated our findings using PDCD5- depleted mouse embryonic fibroblast (M[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"OTUD5 can increase the stability of TP53 and PDCD5 through deubiquitination [22] (Figure 3D)."
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"Conversely, reintroduction of PDCD5 in PDCD5 −/− MEF cells dramatically restored OTUD5 WT function in promoting p53 activation."
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"To this end, 1mug of p53 and increasing amounts of Flag-OTUD5 were cotransfected into H1299 cells."
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"Importantly, we found that OTUD5 promotes the p53 pathway in a PDCD5-dependent manner."
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"As expected, overexpression of the PDCD5 E94D mutant failed to reactivate p53 even with OTUD5 WT present, suggesting that OTUD5 activated p53 via PDCD5 stabilization during response to genotoxic stres[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Consequently, knocking-down PDCD5 abrogates the effect of OTUD5 overexpression on p53 stabilization, highlighting the critical role of PDCD5 in OTUD5-mediated p53 activation ( Fig. 5E )."
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"As expected, overexpression of the PDCD5 E94D mutant failed to reactivate p53 even with OTUD5 WT present, suggesting that OTUD5 activated p53 via PDCD5 stabilization during response to genotoxic stres[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Therefore, OTUD5 and YAF2 promote the TP53 signal pathway in a PDCD5-dependent manner, highlighting the critical role of the PDCD5 network, which acts as a central hub in the regulation of genotoxic s[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, we showed that OTUD5 mediated the sequential activation of PDCD5 and p53 in response to genotoxic stress."
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"The knockdown of OTUD5 inactivated p53 and PDCD5, promoting the proliferation and metastasis of NSCLC cells while inhibiting their apoptosis."
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"Importantly, overexpression of wild-type OTUD5 robustly increased the levels of endogenous PDCD5, as well as p53."
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