IndraLab

Statements

OTUD5 activates TP53. 6 / 8
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"Deubiquitinase OTUD5 mediates the sequential activation of PDCD5 and p53 in response to genotoxic stress."
25499082
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"Overexpression of OTUD5 efficiently enhanced the activation of both PDCD5 and p53."
25499082
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"The knockdown of OTUD5 inactivated p53 and PDCD5, promoting the proliferation and metastasis of NSCLC cells while inhibiting their apoptosis."
32248621
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"The function of OTUD5 is required to allow the rapid activation of p53 dependent transcription and a p53 dependent apoptosis in response to DNA damage stress."
24143256
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"OTU deubiquitinase (OTUD5) binds to PDCD5inresponseto etoposide treatment and effectively mediates the sequential activation of both PDCD5 and P53."
27398268
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"To this end, 1mug of p53 and increasing amounts of Flag-OTUD5 were cotransfected into H1299 cells."
24143256