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Statements

OTUD5 inhibits TP53. 3 / 5
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"The knockdown of OTUD5 inactivated p53 and PDCD5, promoting the proliferation and metastasis of NSCLC cells while inhibiting their apoptosis."
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"In line with this, overexpression of OTUD5 can block p53 activation‐induced GPX4 downregulation (Figure 4C)."
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"Moreover, ectopic expression of phosphomimic KAP1 also rescued the telomere MMEJ defect in OTUD5-depleted Trf1 ;Trf2 ;Ku70 ;p53 ;Cre-ER MEFs (Fig. 5g, Supplementary Fig. 7d, e)."
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