IndraLab

Statements

OTUD5 inhibits IFN-I. 5 / 5
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"Notably, UCHL1, OTUB1, OTUB2, OTUD5, USP25, MYSM1, and MCPIP1 (Figure 3A) negatively regulate virus-induced IFN-I production and antiviral activities by cleaving K63-linked or other types of polyubiquitin chains from TRAF3 or TRAF6."
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"Studies have shown that OTUD5 is able to attenuate the IFN-I response induced by TLR and RLR signaling [5]."
37190070
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"The knockout of OTUD5 leads to faster turnover of STING and impairs IFN-I signaling following cytosolic DNA stimulation, whereas Lyz2-Cre Otud5fl/Y mice and CD11-Cre Otud5fl/Y mice show higher susceptibility to HSV-1 infection than their corresponding control littermates (69)."
34707613
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"Reduction of DUBA could augment IFN-I response, whereas ectopic expression of DUBA has the opposite effect."
29408541
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"As a DUB, DUBA can selectively weaken the K63-linked ubiquitination of TRAF3, assist in the dissociation of TRAF3 from the signal complex containing TBK1, and negatively regulate the production of IFN-I mediated by TRAF3 (75)."
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