IndraLab

Statements

OTUD5 inhibits innate immune response. 5 / 5
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"Also known as DUBA (deubiquitinating enzyme A), the OTUD5 protein was shown to suppress type-I interferon (IFN-I) dependent innate immune response, by cleaving the poly-ubiquitin chain from the IFN-I adaptor protein, thus causing the disassociation of the adaptor from the downstream signaling complex, and ultimately the interruption of the IFN-I signaling cascade."
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"Three human DUBs, CYLD, A20 and DUBA, have been shown to negatively regulate the innate immune response by removing K63 based chains XREF_BIBR, XREF_BIBR, and USP15 inhibits the NFkappaB pathway by removing K48-Ub from IkappaBalpha, preventing its degradation XREF_BIBR."
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"OTUD5 has been shown to suppress the type I interferon dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein."
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"DUBA, a member of the ovarian tumor (OTU) domain containing cysteine protease superfamily, was shown to suppress the type I IFN dependent innate immune response by cleaving the K63 polyubiquitin chain on TRAF3."
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"It has been reported that OTUD5 could suppress the type I interferon dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein TRAF3."
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