IndraLab

Statements

OTUD5 inhibits TRAF3. 6 / 6
| 5 1
reach
"TRAF3 are inhibited by DUBA, OTUB1 and UCHL1 that specilally remove TRAF3 K63‐linked ubiquitination."
28744851
reach
"Structural data suggest that 1) Toll and IL-1R (TIR) domain containing regulators (BCAP, SIGIRR, and ST2) interfere with TIR domain signalosome formation; 2) major deubiquitinases such as A20, CYLD, and DUBA prevent association of TRAF6 and TRAF3 with their partners, inaddition to removing K63 linked ubiquitin chains that serve as a docking platform for downstream effectors; 3) alternative downstream pathways of TLRs also restrict signaling by competing to bind common partners through shared binding sites."
26276688
reach
"TRAF3 activation can in turn be negated by DUBA, a DUB specifically binding TRAF3 and deconjugating its K63 chains [32] ."
22964110
reach
"TRAF3 activation is negatively regulated by SOCS3 and DUBA."
25309543
reach
"TRAF3 activation is inhibited by SOCS3 and DUBA and TRAF 6 is targeted by numerous inhibitors including A20, USP4, CYLD, and others [73,74]."
| PMC
sparser
"TRAF3 are inhibited by DUBA, OTUB1 and UCHL1 that specilally remove TRAF3 K63‐linked ubiquitination."
28744851