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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

OTUD5 inhibits IRF3. 3 / 3

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"These results suggest that DUBA inhibits IRF3 by functioning as a K63-specific DUB that antagonizes the function of TRAF3."

19281271

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"Removal of Lys 63 -linked polyubiquitin chains from RIG-I and TRAF3 by cylindromatosis (CYLD) and deubiquitinating enzyme A (DUBA), respectively, inhibits the RIG-I-dependent activation of IRF3."

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"These results suggest that DUBA inhibits IRF3 by functioning as a K63 specific DUB that antagonizes the function of TRAF3."

19281271

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...