IndraLab

Statements

USP36 affects MYC
7 1 | 1 38 20
USP36 binds MYC.
7 | 6 20
USP36 binds MYC. 10 / 33
7 | 6 20
biogrid
No evidence text available
29467282
sparser
"Myc-USP36 proteins were predominantly localized in nucleoli."
31550441
reach
"Hence, the interaction between USP36 and c-Myc in colon cancer cells was investigated to uncover the potential mechanism underlying the oncogenic effect of USP36."
38517383
sparser
"To complement the USP36 RNAi experiments, we overexpressed myc-USP36 in HeLa cells."
31550441
sparser
"Immunofluorescence analysis showed nucleolar localization of myc-USP36 ( Fig. 4 A)."
31550441
sparser
"Interestingly, myc-USP36 remained in nucleoli throughout the CCCP treatment time course."
31550441
sparser
"Besides, USP36 can interact with c-Myc and FBW7γ, then deubiquitinating c-Myc and counteracting the degradation mediated by FBW7γ ( Sun et al., 2015 )."
34102342
sparser
"Myc-USP36 transfection did not affect Parkin translocation after treatment with CCCP for 2 h or mitochondrial elimination after 24 h ( Fig. 4 A)."
31550441
reach
"For example, as demonstrated by Sun and colleagues, USP36 could interact with and deubiquitinate c-Myc in nuclear, thus enhancing c-Myc signaling and regulating cell proliferation [ 10 ]."
30975468
reach
"The interaction between c-Myc and USP36 was mediated via Fbxw7γ, reminiscent of the ‘piggyback’ interaction of USP28/Fbw7/c-Myc described by Eilers and colleagues [89] , but this interaction was limit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26410034
USP36 deubiquitinates MYC.
1 | 1 12
USP36 deubiquitinates MYC. 10 / 14
1 | 1 12
ubibrowser
"27919796"
27919796
reach
"The deubiquitinating enzyme USP28 can stabilize c-MYC by interacting with FBW7α [31], whereas USP36 deubiquitinates and stabilizes c-MYC by interacting with FBW7γ, but not with FBW7α [32]."
39513905
reach
"USP36 was found to protect renal function by deubiquitinating SOD2 and c-Myc, attenuating oxidative damage, and promoting cell proliferation25."
40225869
reach
"Recent evidence has revealed that c-Myc can be deubiquitylated and regulated by USP28, USP36 and USP37."
29263902
reach
"USP36 plays a direct role in MYC stabilization by interacting with and deubiquitinating MYC."
38785979
reach
"More importantly, in vivo assays further indicated that CBF could not only effectively inhibit colon tumor growth and metastasis but also significantly improve Oxa efficacy in colon tumors, which supported the promising potential of CBF as an emerging therapeutic for colon cancer.In summary, our research demonstrated that USP36 promotes the aggressiveness, chemoresistance, and metastasis of colon cancer by deubiquitinating and stabilizing c-Myc, and uncovered a potential USP36 inhibitor, CBF, in the treatment of colon cancer."
38517383
trips
"The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc."
25775507
reach
"45 USP36 deubiquitinates and stabilizes c-Myc through interactions with FBW7gamma in the nucleolus."
29527331
reach
"USP36 interacts with and deubiquitinates c-Myc in cells and in vitro, leading to the stabilization of c-Myc."
25775507
reach
"For example, as demonstrated by Sun and colleagues, USP36 could interact with and deubiquitinate c-Myc in nuclear, thus enhancing c-Myc signaling and regulating cell proliferation [ 10 ]."
30975468
USP36 activates MYC.
| 7
USP36 activates MYC. 7 / 8
| 7
reach
"Despite this, USP36 could effectively inhibit MYC degradation initiated by both Fbw7g and Fbw7α, thereby indicating that USP36 governs the final stage of Fbw7-mediated MYC degradation within the nucleolus, while cooperating with USP28 in the nucleoplasm."
38785979
reach
"Knockdown of either Usp28 or Usp36 downregulates Myc and suppresses cancer cell proliferation in cell culture."
26459133
reach
"Mechanically, USP36 enhances c-Myc protein stabilization in HCT116 cells via deubiquitination."
38517383
reach
"XREF_BIBR - XREF_BIBR Moreover, the USP37 and USP36 can promote tumorigenesis by stabilizing c-Myc."
32140262
reach
"In contrast, knockdown of hUTP14a results in increased c-Myc ubiquitination ( Fig. 3 C), demonstrating that hUTP14a stabilizes c-Myc by inhibiting ubiquitination of c-Myc.As USP36 stabilizes c-Myc in [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30343112
reach
"USP36 modulates the activity of the Hippo/YAP, PRL1/Snail2, c-Myc/SOD2, CEP63/YAP1, Fbw7g/USP36/c-Myc, ERK/AKT ALR (augmentation of liver regeneration)/MDM2, and USP36/PARP1 pathways through interaction with specific components and exertion of deubiquitinating effects (Figure 2)."
38785979
reach
"This was verified by the Ub-AMC hydrolysis assay, which showed that CBF inhibits the enzymatic activity of USP36 with an IC50 at 2.75 μM. Notably, the stabilization of c-Myc promoted by USP36 overexpression in HCT116 cells was blocked after CBF intervention.Finally, we further explored the potential of CBF against colon cancer."
38517383
USP36 ubiquitinates MYC.
| 6
USP36 leads to the ubiquitination of MYC. 5 / 5
| 5
reach
"USP36, another DUB, also reverses c-MYC ubiquitylation in the nucleolus by interacting with FBXW7γ but not with FBXW7α [ 83 ]."
32113998
reach
"Interestingly, OST-01 significantly inhibited USP36, a nucleolar protein deubiquitinase [10, 11], which lead to ubiquitination and degradation of c-Myc, NPM1, and nucleostemin (Fig. 1D and H)."
38233463
reach
"Therefore, these data suggest that the c-Myc ubiquitination and degradation mediated by USP36 may play a role in the ischemic acute injury of renal tubular epithelial cells.Mitochondria generate more [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30975468
reach
"Accordingly, USP36 knock-down increased c-Myc and NPM1 ubiquitination (Fig. 1I)."
38233463
reach
"In contrast, USP36 overexpression rescued OST-01-induced c-Myc and NPM1 ubiquitination (Fig. 1J)."
38233463
Mutated USP36 leads to the ubiquitination of MYC. 1 / 1
| 1
reach
"Mutation of USP36 cysteine 131 to alanine was sufficient to block the stabilising effect of USP36 on c-Myc protein levels and increase ubiquitinated c-Myc."
26410034
USP36 increases the amount of MYC.
| 4
USP36 increases the amount of MYC. 4 / 4
| 4
reach
"Consistently, knockdown of USP36 reduces the levels of c-Myc and suppresses cell proliferation."
25775507
reach
"The overexpression of USP36 increased c-Myc protein level in ischemia treated HK-2 cells, without affecting its mRNA level."
30975468
reach
"Previous studies have established that overexpression of Wild-type USP36, but not the catalytic-inactive C131A mutant, deubiquitinated c-Myc and increased the levels of endogenous c-Myc in vitro [ 20 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38307305
reach
"The depletion of USP36 dramatically decreases c-Myc levels as previously described [ 20 ] ( Fig. 3 D)."
30343112
USP36 inhibits MYC.
| 2
USP36 inhibits MYC. 2 / 2
| 2
reach
"Thereafter, qRT‐PCR assays were performed on FBXW7, SKP2, USP28, and USP36, which confirmed that Dem could interact with FBXW7 and downregulate the expression of c‐Myc."
34766156
reach
"Degradation of c-MYC is inhibited by de-ubiquitination, and the ubiquitin-specific proteases USP28 and USP36 increase c-MYC stability by deubiquitination, protecting c-MYC from degradation ."
40000737
USP36 decreases the amount of MYC.
| 1
USP36 decreases the amount of MYC. 1 / 1
| 1
reach
"Accordingly, total intracellular c-Myc levels were also reduced by serum-deprivation stimulation and elevated by USP36 overexpression."
30975468
USP36 is modified
51 | 5
USP36 is phosphorylated.
51 |
USP36 is phosphorylated on S742. 8 / 8
8 |
hprd
No evidence text available
20068231
hprd
No evidence text available
17924679
hprd
No evidence text available
19691289
hprd
No evidence text available
19651622
hprd
No evidence text available
19664995
hprd
No evidence text available
19007248
hprd
No evidence text available
18691976
hprd
No evidence text available
16565220
USP36 is phosphorylated on S464. 6 / 6
6 |
hprd
No evidence text available
20068231
hprd
No evidence text available
19691289
hprd
No evidence text available
19664995
hprd
No evidence text available
19007248
hprd
No evidence text available
19413330
hprd
No evidence text available
18669648
USP36 is phosphorylated on S682. 5 / 5
5 |
hprd
No evidence text available
20068231
hprd
No evidence text available
19691289
hprd
No evidence text available
19664995
hprd
No evidence text available
19413330
hprd
No evidence text available
18669648
USP36 is phosphorylated on S667. 4 / 4
4 |
hprd
No evidence text available
20068231
hprd
No evidence text available
19691289
hprd
No evidence text available
19007248
hprd
No evidence text available
18669648
USP36 is phosphorylated on T680. 4 / 4
4 |
hprd
No evidence text available
19664995
hprd
No evidence text available
19413330
hprd
No evidence text available
18669648
hprd
No evidence text available
20068231
USP36 is phosphorylated on T581. 3 / 3
3 |
hprd
No evidence text available
20068231
hprd
No evidence text available
19691289
hprd
No evidence text available
17081983
USP36 is phosphorylated on S952. 3 / 3
3 |
hprd
No evidence text available
20068231
hprd
No evidence text available
19664995
hprd
No evidence text available
17081983
USP36 is phosphorylated on S580. 3 / 3
3 |
hprd
No evidence text available
20068231
hprd
No evidence text available
19691289
hprd
No evidence text available
18691976
USP36 is phosphorylated on S582. 3 / 3
3 |
hprd
No evidence text available
18669648
hprd
No evidence text available
20068231
hprd
No evidence text available
19691289
USP36 is phosphorylated on S713. 3 / 3
3 |
hprd
No evidence text available
20068231
hprd
No evidence text available
19691289
hprd
No evidence text available
19007248
USP36 is phosphorylated on S679. 2 / 2
2 |
hprd
No evidence text available
18669648
hprd
No evidence text available
19664995
USP36 is phosphorylated on S513. 2 / 2
2 |
hprd
No evidence text available
19413330
hprd
No evidence text available
19691289
USP36 is phosphorylated on S515. 2 / 2
2 |
hprd
No evidence text available
19691289
hprd
No evidence text available
19413330
USP36 is phosphorylated on Y874. 1 / 1
1 |
hprd
No evidence text available
17081983
USP36 is phosphorylated on S429. 1 / 1
1 |
hprd
No evidence text available
19691289
USP36 is phosphorylated on S671. 1 / 1
1 |
hprd
No evidence text available
20068231
USP36 is ubiquitinated.
| 5
USP36 is ubiquitinated. 5 / 5
| 5
sparser
"Studies have confirmed the ubiquitylation of USP7 [ xref ], USP36 [ xref ], DUB-1 [ xref ] and DUB-1A [ xref ], but limited data are available regarding the significance of these modifications."
28659380
sparser
"In order to confirm the ubiquitination of USP36, co-immunoprecipitation was also performed with an anti-HA antibody (Roche Applied Science, Mannheim, Germany) and Western blot analysis was performed w[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15809067
sparser
"Ubiquitination of USP7 (K869), USP24 (K421, K656) and USP36 (K338) were down-regulated."
33865438
sparser
"USP7 ( xref ), USP36 ( xref ) and DUB-1 ( xref , xref ) are also ubiquitinated, although the importance of these modifications is unknown."
19489724
sparser
"We first studied how USP36 ubiquitination is regulated upon replication stress, and found decreased USP36 polyubiquitination following HU treatment (Figure xref )."
33237263
USP36 affects EXOSC10
5 | 24 23
USP36 sumoylates EXOSC10.
| 15 10
USP36 sumoylates EXOSC10. 10 / 23
| 14 9
sparser
"USP36 facilitates the SUMOylation of EXOSC10 by functioning as a SUMO E3 enzyme, thereby enhancing nucleolar RNA exoribonuclease functionality and cell proliferation."
38785979
sparser
"Interestingly, USP36 markedly promoted EXOSC10 SUMOylation by both SUMO1 (Figure xref ) and SUMO2 ( xref )."
36912080
sparser
"To test whether USP36 directly SUMOylates EXOSC10, we performed in vitro SUMOylation assays using recombinant proteins."
36912080
sparser
"Notably, USP36 markedly increased EXOSC10 SUMOylation by SUMO1 in vitro , demonstrating that USP36 acts as a SUMO E3 for EXOSC10."
36912080
reach
"Furthermore, USP36 can also partake in the SUMOylation of EXOSC10 in conjunction with NPM1."
38785979
reach
"USP36 SUMOylates EXOSC10 in cells and in vitro."
36912080
sparser
"Together, these data suggest that EXOSC10 SUMOylation by USP36 plays a critical role in rRNA processing."
36912080
reach
"These results suggest that USP36 acts as a SUMO ligase to SUMOylate EXOSC10 and promote the nucleolar RNA exosome function in ribosome biogenesis and cell growth."
36912080
reach
"Furthermore, USP36 could be detected in a protein complex together with EXOSC10 and NMP1 (Fig. 4B), suggesting that USP36 could be implicated in the SUMOylation of EXOSC10."
38279024
reach
"Inclusion of USP36 (1–420), but not USP36(421–800), caused detectable SUMOylation of wild-type EXOSC10, while the K583R mutant form of EXOSC10 could not be modified under the same conditions (Fig. 5C)."
38279024
USP36 sumoylates EXOSC10 on K583. 2 / 2
| 1 1
sparser
"In this study, we report that the key RNA exosome component EXOSC10 is SUMOylated at K583 by USP36 in the nucleolus."
36912080
reach
"As ribosome biogenesis is a complex and dynamic cellular process and is subjected to extensive regulation in response to growth signals and cellular stressors, it is conceivable that the function of the nucleolar RNA exosome is also highly regulated.In this study, we report that the key RNA exosome component EXOSC10 is SUMOylated at K583 by USP36 in the nucleolus."
36912080
USP36 binds EXOSC10.
5 | 5 13
USP36 binds EXOSC10. 10 / 23
5 | 5 13
sparser
"As shown in Figure xref , knockdown of EXOSC10 abrogated the interaction of USP36 with the exosome core components EXOSC3 and EXOSC4, suggesting that USP36 interaction with EXOSC10 is critical for its interaction with the core RNA exosome complex."
36912080
sparser
"We found that RNase treatment indeed reduced, but did not abolish, the interaction between USP36 and EXOSC10 in both 293 (Figure xref ) and HeLa cells ( xref ), whereas the interaction of USP36 with RPL30 and RPS27a was abolished by the RNase treatment, suggesting that USP36 may directly interact with EXOSC10 and that this interaction is facilitated by RNA-containing pre-ribosome particles."
36912080
sparser
"As shown in Figure xref , recombinant His-USP36 protein purified from bacteria ( xref ) was specifically bound by purified GST–EXOSC10, but not GST alone, indicating that USP36 directly interacts with EXOSC10 in vitro ."
36912080
sparser
"EXOSC10 and USP36 interact via their C-terminal domains."
36912080
sparser
"To understand how USP36 interacts with EXOSC10, we mapped the binding domains between USP36 and EXOSC10 using co-IP–IB assays."
36912080
sparser
"As shown in Figure xref , the C-terminal nucleolar localization signal (NoLS)- ( xref , xref ) containing region (amino acids 801–1121), but not the N-terminal USP domain-containing (amino acids 1–420) and the middle (amino acids 421–800) regions, interacts with EXOSC10, indicating that EXOSC10 binds to the C-terminus of USP36 (Figure xref )."
36912080
sparser
"Furthermore, RNase treatment also reduced, but did not abolish, the interaction of USP36 with the C-terminal Lasso domain of EXOSC10 ( xref ) or the interaction of EXOSC10 with USP36 801–1121 ( xref )."
36912080
sparser
"Together, these results indicate that the C-terminal region of USP36 directly interacts with the C-terminal Lasso domain of EXOSC10 (Figure xref , xref ) that can also be facilitated by the association with RNA."
36912080
sparser
"We performed co-IP assay using the lysates from the isolated nucleolar fraction and further confirmed that USP36 interacts with EXOSC10 in the nucleolus (Figure xref )."
36912080
reach
"Although expression level of USP36 was not affected significantly by hypoxia (Fig. 4C), hypoxic treatment abolished the interaction between USP36 and EXOSC10 without significantly affecting the interaction between NPM1 and EXOSC10 (Fig. 4B)."
38279024
USP36 increases the amount of EXOSC10.
| 3
USP36 increases the amount of EXOSC10. 3 / 3
| 3
reach
"As shown in Supplementary Figure S4A, knockdown of USP36 did not reduce the levels of EXOSC10 or other tested exosome core subunits including EXOSC2, EXOSC3 and EXOSC4."
36912080
reach
"Consistently, knockdown of USP36 significantly reduced the levels of EXOSC10 SUMOylation in cells by both exogenously expressed SUMO1 as determined by Ni -NTA PD assays (Figure 3C) and endogenous SUMO shown as the modified EXOSC10 band in IB assays (Figure 3D)."
36912080
reach
"To understand whether USP36-mediated SUMOylation affects EXOSC10 protein levels, we performed USP36 knockdown experiments."
36912080
USP36 deubiquitinates EXOSC10.
| 1
USP36 deubiquitinates EXOSC10. 1 / 1
| 1
reach
"However, while we did observe the marginal ubiquitination of the exogenously expressed EXOSC10 that can be deubiquitinated by WT USP36, but not the catalytically inactive C131A mutant (Supplementary Figure S3A), the ubiquitination of endogenous EXOSC10 is undetectable (Supplementary Figure S3B), indicating that the steady-state levels of EXOSC10 ubiquitination under normal cell growth conditions is too low to be regulated by USP36."
36912080
MYC affects USP36
2 7 | 9 20
MYC binds USP36.
7 | 6 20
USP36 binds MYC. 10 / 33
7 | 6 20
biogrid
No evidence text available
29467282
sparser
"Myc-USP36 proteins were predominantly localized in nucleoli."
31550441
reach
"Hence, the interaction between USP36 and c-Myc in colon cancer cells was investigated to uncover the potential mechanism underlying the oncogenic effect of USP36."
38517383
sparser
"To complement the USP36 RNAi experiments, we overexpressed myc-USP36 in HeLa cells."
31550441
sparser
"Immunofluorescence analysis showed nucleolar localization of myc-USP36 ( Fig. 4 A)."
31550441
sparser
"Interestingly, myc-USP36 remained in nucleoli throughout the CCCP treatment time course."
31550441
sparser
"Besides, USP36 can interact with c-Myc and FBW7γ, then deubiquitinating c-Myc and counteracting the degradation mediated by FBW7γ ( Sun et al., 2015 )."
34102342
sparser
"Myc-USP36 transfection did not affect Parkin translocation after treatment with CCCP for 2 h or mitochondrial elimination after 24 h ( Fig. 4 A)."
31550441
reach
"For example, as demonstrated by Sun and colleagues, USP36 could interact with and deubiquitinate c-Myc in nuclear, thus enhancing c-Myc signaling and regulating cell proliferation [ 10 ]."
30975468
reach
"The interaction between c-Myc and USP36 was mediated via Fbxw7γ, reminiscent of the ‘piggyback’ interaction of USP28/Fbw7/c-Myc described by Eilers and colleagues [89] , but this interaction was limit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26410034
MYC decreases the amount of USP36.
2 |
MYC decreases the amount of USP36. 2 / 3
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
MYC inhibits USP36.
| 2
MYC inhibits USP36. 2 / 2
| 2
reach
"Upregulation of c-MYC reversed the downregulation of hnRNPH1/H2 induced inhibition of USP36."
35133629
reach
"Moreover, the ubiquitination level of c-Myc was reduced by overexpressing USP36 in HCT116 cells, and this effect was blocked by CBF (Figure 5D)."
38517383
MYC deubiquitinates USP36.
| 1
MYC leads to the deubiquitination of USP36. 1 / 1
| 1
reach
"Degradation of c-MYC is inhibited by de-ubiquitination, and the ubiquitin-specific proteases USP28 and USP36 increase c-MYC stability by deubiquitination, protecting c-MYC from degradation ."
40000737
USP36 affects DGCR8
4 | 19 11
USP36 sumoylates DGCR8.
| 13 7
USP36 sumoylates DGCR8. 10 / 20
| 13 7
reach
"USP36 interacts with the DGCR8-Drosha complex and promotes DGCR8 SUMOylation specifically by SUMO2."
36950067
sparser
"USP36 interacts with the microprocessor complex and promotes DGCR8 SUMOylation, specifically modified by SUMO2."
36950067
reach
"USP36 SUMOylates DGCR8."
36950067
reach
"Intriguingly, coexpression of USP36 markedly increased the SUMOylation of DGCR8 modified by SUMO2, but not SUMO1."
36950067
reach
"The Ubiquitin-specific Protease USP36 Associates with the Microprocessor Complex and Regulates miRNA Biogenesis by SUMOylating DGCR8."
36950067
reach
"USP36 interacts with the microprocessor complex and promotes DGCR8 SUMOylation, specifically modified by SUMO2."
36950067
reach
"Significance:. This study identifies that USP36 mediates DGCR8 SUMOylation by SUMO2 and is critical for miRNA biogenesis."
36950067
sparser
"Similarly, DGCR8 SUMOylation by USP36 does not affect the DGCR8-Drosha microprocessor complex formation but promotes DGCR8 binding to pri-miRNAs, suggesting that SUMOylation of DGCR8 by USP36 increases its affinity to pri-miRNAs."
36950067
reach
"For instance, the ubiquitin-specific protease (USP36) has been found to associate with the Microprocessor complex and regulate miRNA biogenesis by SUMOylating DGCR8 [21]."
39346566
sparser
"Of note, we observed that USP36 specifically promotes DGCR8 SUMOylation by SUMO2, but not SUMO1, although it can promote protein SUMOylate by either SUMO1 or SUMO2 ( xref )."
36950067
USP36 binds DGCR8.
4 | 2 4
DGCR8 binds USP36. 10 / 10
4 | 2 4
reach
"To examine where USP36 binds to Drosha and DGCR8, we also performed co-IP and IB experiments using a panel of Flag-DGCR8 mutants (Fig. 3E and F) and Flag-Drosha mutants (Fig. 3G and H)."
36950067
reach
"It is likely that SUMOylation of DGCR8 may induce confirmational changes that favor the microprocessor complex targeting of pri-miRNAs and thus increase the activity of Drosha-mediated processing of the pri-miRNAs.Our binding domain mapping results reveal that USP36 binds to DGCR8 and Drosha via distinct domains, suggesting that the three proteins form a multiprotein complex."
36950067
biogrid
No evidence text available
34188037
sparser
"As shown in xref , knockdown of Drosha did not abolish the interaction of USP36 with DGCR8."
36950067
biogrid
No evidence text available
36912080
sparser
"Similarly, DGCR8 SUMOylation by USP36 does not affect the DGCR8-Drosha microprocessor complex formation but promotes DGCR8 binding to pri-miRNAs, suggesting that SUMOylation of DGCR8 by USP36 increases its affinity to pri-miRNAs."
36950067
sparser
"As show in xref , USP36 interacts with the C-terminus region of DGCR8 that contains two dsRBD domains."
36950067
biogrid
No evidence text available
36950067
biogrid
No evidence text available
36950067
sparser
"Both DGCR8 and Drosha can bind to the N-terminus and C-terminus of USP36 albeit DGCR8 binds strongly to the C-terminus of USP36 whereas Drosha binds strongly to the N-terminus of USP36."
36950067
USP36 increases the amount of DGCR8.
| 3
USP36 increases the amount of DGCR8. 3 / 3
| 3
reach
"As shown in Fig. 4A, overexpression of USP36 did not increase the levels of DGCR8 and Drosha in multiple tested cell lines."
36950067
reach
"Also, knockdown of USP36 by siRNA (Fig. 4B) or lentiviral-encoded shRNA (Fig. 4C) did not reduce the levels of DGCR8 and Drosha."
36950067
reach
"USP36-mediated SUMOylation does not affect the levels of DGCR8 and the formation of the Drosha-DGCR8 complex, but promotes the binding of DGCR8 to pri-miRNAs."
36950067
USP36 deubiquitinates DGCR8.
| 1
USP36 deubiquitinates DGCR8. 1 / 1
| 1
reach
"Indeed, although we did observe the marginal ubiquitination of exogenously expressed DGCR8 that can be deubiquitinated by WT USP36, but not the catalytically-inactive C131A mutant (Supplementary Fig. S4A), the levels of endogenous DGCR8 ubiquitination are below detectable (Supplementary Fig. S4B), suggesting that the steady-state levels of DGCR8 ubiquitination under normal cell growth conditions are too low to be regulated by USP36."
36950067
USP36 affects SNAI1
2 | 13 15
USP36 binds SNAI1.
2 | 2 15
SNAI1 binds USP36. 10 / 19
2 | 2 15
biogrid
No evidence text available
31911859
biogrid
No evidence text available
31911859
sparser
"Stable protein complexes between USP36 and Snail1 were readily detected in the nucleoli even in the presence of 500 mM NaCl (Fig.  xref )."
37833415
sparser
"Lys157 of Snail1 is essential for Snail1-USP36 complex formation and ribotoxic stress-induced Snail1 nucleolar accumulation."
37833415
sparser
"To address whether USP36 binds to ubiquitinated Snail1, we employed a specific E1 inhibitor, TAK-243, to block protein ubiquitination."
37833415
sparser
"As shown in Supplementary Fig.  xref , USP36 effectively interacted with Snail1 regardless of the status of its ubiquitination."
37833415
sparser
"To identify binding segments important for USP36-Snail1 interaction, we constructed a series of truncation mutants."
37833415
sparser
"As shown in Fig.  xref , the N-terminus of USP36 (1–423 aa) interacted with the C-terminus of Snail1 (152–264 aa)."
37833415
sparser
"Indeed, further experiments showed that the C2H2-type 1 Zinc finger (154–176 aa, ZnF1) of Snail1 protein is responsible for USP36-Snail1 interaction (Fig.  xref )."
37833415
sparser
"By contrast, ectopic expression of ATXN3 upregulated both Snai11 WT and Snail1 K157R (Fig.  xref ), suggesting that K157 is critical for Snail1-USP36 interaction."
37833415
USP36 increases the amount of SNAI1.
| 4
USP36 increases the amount of SNAI1. 4 / 4
| 4
reach
"Ectopic expression of USP36 increased Snail1 protein expression in a dose-dependent manner (Supplementary Fig. S1c)."
37833415
reach
"In addition, ectopic expression of USP36 led to upregulated expression of Snail1 , Snail1 , or Snail1 , but not Snail1 (Fig. 3i, j)."
37833415
reach
"Consistently, USP36 upregulated expression of Snai11 , but not Snail1 (Fig. 4g)."
37833415
reach
"Notably, ectopic expression of USP36, but not USP36 defective in deubiquitinase activity , upregulated endogenous Snail1 protein expression in both SUM159 and HCC1806 cells (Fig. 2e)."
37833415
USP36 activates SNAI1.
| 4
USP36 activates SNAI1. 4 / 4
| 4
reach
"Silencing of USP36 markedly reduced Snail1 protein half-life (Fig. 3c)."
37833415
reach
"Notably, while Snail1 protein was more stable than Snail1 , ectopic expression of USP36 significantly upregulated Snail1 protein half-life, but not Snail1 (Fig. 3k)."
37833415
reach
"Importantly, while a selective p38 inhibitor, SB203580, failed to block the HHT-induced upregulation of USP36 and Snail1, inhibition of JNK by SP600125 completely inhibited HHT-induced upregulation of the mRNA and protein expression of USP36 (Supplementary Fig. S5b–d)."
37833415
reach
"Conversely, the knockdown of USP36 led to the downregulation of Snail1 (Supplementary Fig. S1d), which was completely rescued by the restoration of USP36, but not USP36 (Fig. 2f)."
37833415
USP36 deubiquitinates SNAI1.
| 3
USP36 deubiquitinates SNAI1. 3 / 3
| 3
reach
"Ribotoxic stress elevates USP36 expression which in turn deubiquitinates and stabilizes Snail1 in the nucleolus."
37833415
reach
"Subsequent sub-screening identified 23 DUBs that interact with SNAI1, out of which USP29, USP36, and USP37 upregulate and reduce polyubiquitination of the SNAI1 protein."
| PMC
reach
"Next, we aimed to identify specific amino acid residues on the Snail1 protein that are deubiquitinated by USP36."
37833415
USP36 affects NPM1
1 9 | 9 6
USP36 binds NPM1.
9 | 4 6
NPM1 binds USP36. 10 / 19
9 | 4 6
biogrid
No evidence text available
28514442
sparser
"NoLS sequence guides USP36 to the nucleolus by interaction with NPM1, and deletion of NoLS led to the loss of USP36 interaction with NPM1 as well as its nucleolar localization ( Endo et al., 2009 )."
29533783
biogrid
No evidence text available
19679658
biogrid
No evidence text available
19679658
biogrid
No evidence text available
19679658
sparser
"This prompted us to check whether 6p22lncRNAs interfere with the interaction between USP36 and NPM1."
29533783
sparser
"We observed that, in CASC15-003- and NBAT1-overexpressing cells, USP36 interaction with NPM1 was compromised ( Figure 6 M)."
29533783
reach
"This prompted us to check whether 6p22lncRNAs interfere with the interaction between USP36 and NPM1."
29533783
reach
"We observed that, in CASC15-003- and NBAT1-overexpressing cells, USP36 interaction with NPM1 was compromised ( Figure 6 M)."
29533783
reach
"6p22lncRNAs control CHD7 stability by modulating the USP36 nucleolar localization by interfering with USP36 and NPM1 interaction."
29533783
USP36 deubiquitinates NPM1.
1 | 3
USP36 deubiquitinates NPM1. 4 / 4
1 | 3
reach
"It was shown that NPM1 is deubiquitinated by USP36 (ubiquitin specific peptidase 36) in the nucleolus stabilizing NPM1 [52], which is in turn required for USP36 accumulation [53]."
29157973
signor
"USP36 deubiquitylated the nucleolar proteins nucleophosmin/B23 and fibrillarin, and stabilized them by counteracting ubiquitylation-mediated proteasomal degradation."
19208757
reach
"Interestingly, OST-01 significantly inhibited USP36, a nucleolar protein deubiquitinase [10, 11], which lead to ubiquitination and degradation of c-Myc, NPM1, and nucleostemin (Fig. 1D and H)."
38233463
reach
"We also tested whether a nucleolar deubiquitinase USP36, which deubiquitinates NPM XREF_BIBR, affects the MG132 caused NPM nucleolar retention in the UV treated cells."
23554979
USP36 ubiquitinates NPM1.
| 2
USP36 leads to the ubiquitination of NPM1. 2 / 2
| 2
reach
"Accordingly, USP36 knock-down increased c-Myc and NPM1 ubiquitination (Fig. 1I)."
38233463
reach
"In contrast, USP36 overexpression rescued OST-01-induced c-Myc and NPM1 ubiquitination (Fig. 1J)."
38233463
EXOSC10 affects USP36
5 | 5 13
USP36 binds EXOSC10. 10 / 23
5 | 5 13
sparser
"As shown in Figure xref , knockdown of EXOSC10 abrogated the interaction of USP36 with the exosome core components EXOSC3 and EXOSC4, suggesting that USP36 interaction with EXOSC10 is critical for its interaction with the core RNA exosome complex."
36912080
sparser
"We found that RNase treatment indeed reduced, but did not abolish, the interaction between USP36 and EXOSC10 in both 293 (Figure xref ) and HeLa cells ( xref ), whereas the interaction of USP36 with RPL30 and RPS27a was abolished by the RNase treatment, suggesting that USP36 may directly interact with EXOSC10 and that this interaction is facilitated by RNA-containing pre-ribosome particles."
36912080
sparser
"As shown in Figure xref , recombinant His-USP36 protein purified from bacteria ( xref ) was specifically bound by purified GST–EXOSC10, but not GST alone, indicating that USP36 directly interacts with EXOSC10 in vitro ."
36912080
sparser
"EXOSC10 and USP36 interact via their C-terminal domains."
36912080
sparser
"To understand how USP36 interacts with EXOSC10, we mapped the binding domains between USP36 and EXOSC10 using co-IP–IB assays."
36912080
sparser
"As shown in Figure xref , the C-terminal nucleolar localization signal (NoLS)- ( xref , xref ) containing region (amino acids 801–1121), but not the N-terminal USP domain-containing (amino acids 1–420) and the middle (amino acids 421–800) regions, interacts with EXOSC10, indicating that EXOSC10 binds to the C-terminus of USP36 (Figure xref )."
36912080
sparser
"Furthermore, RNase treatment also reduced, but did not abolish, the interaction of USP36 with the C-terminal Lasso domain of EXOSC10 ( xref ) or the interaction of EXOSC10 with USP36 801–1121 ( xref )."
36912080
sparser
"Together, these results indicate that the C-terminal region of USP36 directly interacts with the C-terminal Lasso domain of EXOSC10 (Figure xref , xref ) that can also be facilitated by the association with RNA."
36912080
sparser
"We performed co-IP assay using the lysates from the isolated nucleolar fraction and further confirmed that USP36 interacts with EXOSC10 in the nucleolus (Figure xref )."
36912080
reach
"Although expression level of USP36 was not affected significantly by hypoxia (Fig. 4C), hypoxic treatment abolished the interaction between USP36 and EXOSC10 without significantly affecting the interaction between NPM1 and EXOSC10 (Fig. 4B)."
38279024
USP36 affects YAP1
| 16 6
USP36 binds YAP1.
| 2 6
USP36 binds YAP1. 7 / 7
| 1 6
sparser
"USP36 interacts with YAP and inhibits YAP polyubiquitination and breakdown, which further promotes esophageal cancer progression (Fig. xref )."
36470870
sparser
"USP36 could associate with YAP and deubiquitinate YAP protein, which further leads to enhanced Hippo/YAP activity."
36470870
sparser
"Molecular studies demonstrated that USP36 associated with the YAP protein and enhanced YAP protein stability by blocking the K48-linked polyubiquitination of YAP."
36470870
sparser
"USP36 could interact with the YAP protein and inhibit YAP K48-linked polyubiquitination."
36470870
reach
"USP36 could associate with YAP and deubiquitinate YAP protein, which further leads to enhanced Hippo/YAP activity."
36470870
sparser
"These findings indicate that USP36 interacts with YAP and plays a role in deubiquitinating YAP, thereby positively influencing Hippo/YAP signaling activity."
38785979
sparser
"We made deletion constructs targeting these domains for interaction analysis, which revealed that the WW domain was necessary for the binding of YAP to USP36, while the USP domain was required for the association of USP36 with YAP (Fig. xref )."
36470870
YAP1 binds USP36 and USP domain. 1 / 1
| 1
reach
"We made deletion constructs targeting these domains for interaction analysis, which revealed that the WW domain was necessary for the binding of YAP to USP36, while the USP domain was required for the association of USP36 with YAP (Fig. 5E, F)."
36470870
USP36 activates YAP1.
| 5
USP36 activates YAP1. 5 / 5
| 5
reach
"USP36 modulates the activity of the Hippo/YAP, PRL1/Snail2, c-Myc/SOD2, CEP63/YAP1, Fbw7g/USP36/c-Myc, ERK/AKT ALR (augmentation of liver regeneration)/MDM2, and USP36/PARP1 pathways through interaction with specific components and exertion of deubiquitinating effects (Figure 2)."
38785979
reach
"Our previous study clarified that ubiquitin-specific peptidase 36 (USP36) accelerates ESCC proliferation and metastasis through stabilizing YAP protein [13]."
38906857
reach
"Since USP36 modulates the Hippo/YAP axis and ESCC progression, we further investigated the potential mechanism."
36470870
reach
"Immunostaining indicated that both the YAP protein and USP36 protein were enriched in the nucleus, while USP36 depletion significantly reduced YAP staining signals in the nucleus (Fig. 5A), this conclusion was observed by the western blot of the distribution of YAP in nucleo-cytoplasmic extracts."
36470870
reach
"USP36 modulates the activity of the Hippo/YAP, PRL1/Snail2, c-Myc/SOD2, CEP63/YAP1, Fbw7g/USP36/c-Myc, ERK/AKT ALR (augmentation of liver regeneration)/MDM2, and USP36/PARP1 pathways through interaction with specific components and exertion of deubiquitinating effects (Figure 2)."
38785979
USP36 deubiquitinates YAP1.
| 4
USP36 deubiquitinates YAP1. 4 / 4
| 4
reach
"USP36 interacts with YAP and inhibits YAP polyubiquitination and breakdown, which further promotes esophageal cancer progression (Fig. 6G)."
36470870
reach
"USP36 could associate with YAP and deubiquitinate YAP protein, which further leads to enhanced Hippo/YAP activity."
36470870
reach
"These findings indicate that USP36 interacts with YAP and plays a role in deubiquitinating YAP, thereby positively influencing Hippo/YAP signaling activity."
38785979
reach
"The ubiquitination assay indicated that USP36 depletion could significantly increase the total YAP ubiquitination level, but USP36 overexpression could decrease the total YAP ubiquitination level (Fig. 6A, B)."
36470870
USP36 increases the amount of YAP1.
| 3
USP36 increases the amount of YAP1. 3 / 3
| 3
reach
"The immuno-blotting data indicated that USP36 depletion reduced YAP protein levels in ECA109, KYSE150, and EC9706 cells, but did not affect TAZ protein levels (Fig. 2B)."
36470870
reach
"The western blotting data showed that USP36 overexpression enhanced YAP protein levels in ECA109 cells (Fig. 2F)."
36470870
reach
"USP36 depletion decreased YAP protein levels, while MG132 treatment diminished this decrease in YAP protein levels (Fig. 5C)."
36470870
USP36 decreases the amount of YAP1.
| 2
USP36 decreases the amount of YAP1. 2 / 2
| 2
reach
"The western blot assay showed that the reduction in YAP protein level induced by USP36 depletion could be reversed by YAP overexpression (Fig. 4J)."
36470870
reach
"The ubiquitination assay indicated that USP36 depletion could significantly increase the total YAP ubiquitination level, but USP36 overexpression could decrease the total YAP ubiquitination level (Fig. 6A, B)."
36470870
USP36 affects ALKBH5
4 | 9 9
USP36 binds ALKBH5.
4 | 3 9
ALKBH5 binds USP36. 10 / 16
4 | 3 9
sparser
"These findings provide valuable insights into the complex molecular interactions involved in tumor formation and highlight the potential of targeting the USP36-ALKBH5 axis as a therapeutic intervention for glioblastoma."
38785979
sparser
"Subsequent mass spectrometry experiments were conducted to unveil the protein interaction partners of ALKBH5, and the results demonstrated the interaction between USP36 and ALKBH5 [ xref ]."
38398118
sparser
"Another m 6 A modifier, ALKBH5, is stabilized by the deubiquitinase USP36 in GSCs, stimulating tumor growth and TMZ resistance [ xref ], and this USP36–ALKBH5 relationship may provide another targetable scaffold in GSCs."
37444568
sparser
"Mass spectrometry and immunoprecipitation were performed to identify the USP36 and ALKBH5 interaction."
36239338
sparser
"Our findings indicate that USP36 regulates the protein degradation and expression of ALKBH5, and the USP36-ALKBH5 axis orchestrates glioma tumorigenesis."
36239338
sparser
"Together, these findings underscore the crucial role of the USP36–ALKBH5 axis in governing GSC cell proliferation, stemness and tumorigenesis, and could potentially lay the groundwork for progressing the development of more potent therapies targeting glioblastoma [ xref , xref ]. xref illustrates the various regulators and mechanisms for dysregulation of m 6 A-related genes discussed in this sector."
38398118
sparser
"For example, the USP36–ALKBH5 axis has been shown to impart resistance to TMZ, the first-line chemotherapeutic agent for standard practice in the management of glioblastoma [ xref ]."
38398118
sparser
"ALKBH5 deficiency decreased PD‐L1 protein level by suppressing ZDHHC3 mRNA expression in an m 6 A modification manner, further enhancing the efficacy of anti‐PD‐1 therapy for GBM. xref ALKBH5 facilitates hypoxia‐induced paraspeckle assembly and IL8 secretion to recruit tumor‐associated macrophages (TAMs) to promote GBM progression. xref Ubiquitin‐specific peptidase 36 (USP36) interacts with and stabilizes ALKBH5, and targeting USP36‐ALKBH5 axis inhibits cell proliferation and self‐renewal of GSCs and sensitized GSCs to temozolomide (TMZ) treatment. xref It has been reported that ALKBH5 maintains tumorigenicity of GBM stem‐like cells (GSCs) by sustaining FOXM1 mRNA expression and cell proliferation program. xref We also found that ALKBH5 expression was associated with malignant proliferation of GBM and stemness of GSCs, but we focused on the alternative splicing events and isoform switch of target genes rather than mRNA expression."
39974663
sparser
"Subsequent studies have also found that ALKBH5 and USP36 interact to maintain stem cell properties in glioblastoma and promote tumor progression (Chang et al., 2023[ xref ])."
39967906
biogrid
No evidence text available
36239338
USP36 deubiquitinates ALKBH5.
| 3
USP36 deubiquitinates ALKBH5. 3 / 3
| 3
reach
"In addition, ubiquitin-specific peptidase 36 (USP36) deubiquitinates and stabilizes ALKBH5, which promotes glioblastoma tumorigenesis and resistance to temozolomide (TMZ) [ 145 ]."
37690652
reach
"For instance, USP36 deubiquitinates ALKBH5 to facilitate the progression of glioblastoma [9], and JOSD2 stabilizes YAP/TAZ to enhance the advancement of cholangiocarcinoma [8]."
40296903
reach
"Corrigendum to: USP36 promotes tumorigenesis and drug sensitivity of glioblastoma by deubiquitinating and stabilizing ALKBH5."
37527558
USP36 activates ALKBH5.
| 2
USP36 activates ALKBH5. 2 / 2
| 2
reach
"Consequently, the deletion of USP36 significantly increased the degradation of ALKBH5, while overexpression of USP36 enhanced ALKBH5 stability in GSC cells."
38398118
reach
"Ubiquitination may also play a role in ALKBH5 biology as preliminary evidence suggested that the USP36, a deubiquitinating enzyme, associates with and promotes ALKBH5 stabilization (87)."
39495907
USP36 increases the amount of ALKBH5.
| 1
USP36 increases the amount of ALKBH5. 1 / 1
| 1
reach
"Accordingly, knockout of the USP36 gene downregulated ALKBH5 expression, thereby significantly increasing the sensitivity of GSC cells to TMZ treatment [54]."
38398118
NPM1 affects USP36
9 | 5 6
NPM1 binds USP36.
9 | 4 6
NPM1 binds USP36. 10 / 19
9 | 4 6
biogrid
No evidence text available
28514442
sparser
"NoLS sequence guides USP36 to the nucleolus by interaction with NPM1, and deletion of NoLS led to the loss of USP36 interaction with NPM1 as well as its nucleolar localization ( Endo et al., 2009 )."
29533783
biogrid
No evidence text available
19679658
biogrid
No evidence text available
19679658
biogrid
No evidence text available
19679658
sparser
"This prompted us to check whether 6p22lncRNAs interfere with the interaction between USP36 and NPM1."
29533783
sparser
"We observed that, in CASC15-003- and NBAT1-overexpressing cells, USP36 interaction with NPM1 was compromised ( Figure 6 M)."
29533783
reach
"This prompted us to check whether 6p22lncRNAs interfere with the interaction between USP36 and NPM1."
29533783
reach
"We observed that, in CASC15-003- and NBAT1-overexpressing cells, USP36 interaction with NPM1 was compromised ( Figure 6 M)."
29533783
reach
"6p22lncRNAs control CHD7 stability by modulating the USP36 nucleolar localization by interfering with USP36 and NPM1 interaction."
29533783
NPM1 activates USP36.
| 1
NPM1 activates USP36. 1 / 1
| 1
reach
"Interestingly, NPM1 itself can target USP36 to nucleoli by direct binding [XREF_BIBR]."
21152184
USP36 affects Circulin-C
| 19
sparser
"Peng et al. observed that the binding of miR-98-5p to vascular cell adhesion molecule 1 (VCAM1) inhibited LDL-induced HUVEC injury, while circ-USP36 overexpression can up-regulate VCAM1 expression by sponging miR-98-5p to promote HUVEC apoptosis [ xref ]."
40098005
sparser
"Furthermore, for the circ_0068087, with similar targeted ROBO1 expression in circ-USP36, it not only aggravates hyperglycemia-induced dysfunction and inflammation of ECs with a sponge of miR-197 in diabetes but also alleviated oxLDL-induced dysfunction in HUVECs partly accompanied by reducing and upregulating miR-186-5p ( xref )."
35722128
sparser
"Ox-LDL promoted the apoptosis and inflammation but suppressed the viability of HUVEC cells through upregulating circ-USP36, thus elevating the expression of VCAM1 via miR-98-5p."
33249762
sparser
"Furthermore, circ-0068087 xref and circ-USP36 xref mediate ox-LDL-induced endothelial cell dysfunction, whereas circ-GNAQ plays an inhibiting impact on endothelial cell senescence xref ."
36171087
sparser
"The circ_0003204 (also called circ-USP36) has been demonstrated to serve as the sponge of several miRNAs and regulated the endothelial injury through different molecules recently."
35722128
sparser
"In the endothelial injury model induced by oxLDL, the levels of circ-USP36 usually increased."
35722128
sparser
"The levels of vascular cell adhesion molecule 1 (VCAM1) and roundabout guidance receptor 1(ROBO1) was also upregulated with the miR-98-5p and miR-20a-5p downregulated and sponged by circ-USP36 in oxLDL-induced injuries, which could both accelerate the endothelial cell injury ( xref , xref )."
35722128
sparser
"However, differently, through absorbing the miR-637 to enhance WNT4, the circ-USP36 had been reported to attenuate the EC proliferation and migration in the oxLDL-induced injury ( xref )."
35722128
sparser
"This study aimed to uncover the function and mechanism of circ-ubiquitin specific peptidase 36 (USP36) in endothelial cells treated with oxidized low-density lipoprotein (ox-LDL)."
33249762
sparser
"Due to the multiple targeted pathways, the epigenetic regulation network of circ-USP36 should be further discussed."
35722128
SNAI1 affects USP36
2 | 2 15
SNAI1 binds USP36. 10 / 19
2 | 2 15
biogrid
No evidence text available
31911859
biogrid
No evidence text available
31911859
sparser
"Stable protein complexes between USP36 and Snail1 were readily detected in the nucleoli even in the presence of 500 mM NaCl (Fig.  xref )."
37833415
sparser
"Lys157 of Snail1 is essential for Snail1-USP36 complex formation and ribotoxic stress-induced Snail1 nucleolar accumulation."
37833415
sparser
"To address whether USP36 binds to ubiquitinated Snail1, we employed a specific E1 inhibitor, TAK-243, to block protein ubiquitination."
37833415
sparser
"As shown in Supplementary Fig.  xref , USP36 effectively interacted with Snail1 regardless of the status of its ubiquitination."
37833415
sparser
"To identify binding segments important for USP36-Snail1 interaction, we constructed a series of truncation mutants."
37833415
sparser
"As shown in Fig.  xref , the N-terminus of USP36 (1–423 aa) interacted with the C-terminus of Snail1 (152–264 aa)."
37833415
sparser
"Indeed, further experiments showed that the C2H2-type 1 Zinc finger (154–176 aa, ZnF1) of Snail1 protein is responsible for USP36-Snail1 interaction (Fig.  xref )."
37833415
sparser
"By contrast, ectopic expression of ATXN3 upregulated both Snai11 WT and Snail1 K157R (Fig.  xref ), suggesting that K157 is critical for Snail1-USP36 interaction."
37833415
Circulin-C affects USP36
| 19
sparser
"Peng et al. observed that the binding of miR-98-5p to vascular cell adhesion molecule 1 (VCAM1) inhibited LDL-induced HUVEC injury, while circ-USP36 overexpression can up-regulate VCAM1 expression by sponging miR-98-5p to promote HUVEC apoptosis [ xref ]."
40098005
sparser
"Furthermore, for the circ_0068087, with similar targeted ROBO1 expression in circ-USP36, it not only aggravates hyperglycemia-induced dysfunction and inflammation of ECs with a sponge of miR-197 in diabetes but also alleviated oxLDL-induced dysfunction in HUVECs partly accompanied by reducing and upregulating miR-186-5p ( xref )."
35722128
sparser
"Ox-LDL promoted the apoptosis and inflammation but suppressed the viability of HUVEC cells through upregulating circ-USP36, thus elevating the expression of VCAM1 via miR-98-5p."
33249762
sparser
"Furthermore, circ-0068087 xref and circ-USP36 xref mediate ox-LDL-induced endothelial cell dysfunction, whereas circ-GNAQ plays an inhibiting impact on endothelial cell senescence xref ."
36171087
sparser
"The circ_0003204 (also called circ-USP36) has been demonstrated to serve as the sponge of several miRNAs and regulated the endothelial injury through different molecules recently."
35722128
sparser
"In the endothelial injury model induced by oxLDL, the levels of circ-USP36 usually increased."
35722128
sparser
"The levels of vascular cell adhesion molecule 1 (VCAM1) and roundabout guidance receptor 1(ROBO1) was also upregulated with the miR-98-5p and miR-20a-5p downregulated and sponged by circ-USP36 in oxLDL-induced injuries, which could both accelerate the endothelial cell injury ( xref , xref )."
35722128
sparser
"However, differently, through absorbing the miR-637 to enhance WNT4, the circ-USP36 had been reported to attenuate the EC proliferation and migration in the oxLDL-induced injury ( xref )."
35722128
sparser
"This study aimed to uncover the function and mechanism of circ-ubiquitin specific peptidase 36 (USP36) in endothelial cells treated with oxidized low-density lipoprotein (ox-LDL)."
33249762
sparser
"Due to the multiple targeted pathways, the epigenetic regulation network of circ-USP36 should be further discussed."
35722128
USP36 activates cell population proliferation. 10 / 18
| 1 16
reach
"USP36 Promotes NB Cell Proliferation and Tumor Phenotype."
34056606
reach
"Multiple lines of evidence have indicated that USP36 promotes cell proliferation in a wide range of cancers through deubiquitination and stabilization of oncoproteins."
38785979
reach
"Functionally, elevated USP36 could promote proliferation, migration, and invasion of CRC cells in vitro and in vivo."
39343961
reach
"Consistently, depletion of USP36 markedly reduced the levels of tested mature miRNAs and induced overexpression of a SUMOylation-defective mutant of DGCR8 suppressed cell proliferation."
36950067
reach
"RBM28/p53 axis mediates USP36-induced proliferation and metastasis."
39343961
reach
"USP36 promotes CRC cell proliferation, migration, and invasion in vitro."
39343961
reach
"Our previous study clarified that ubiquitin-specific peptidase 36 (USP36) accelerates ESCC proliferation and metastasis through stabilizing YAP protein [13]."
38906857
reach
"As the above study revealed, USP36 promoted the cell proliferation and inhibited autophagy, while inhibiting autophagy have no impact on the cell proliferation."
28350092
reach
"Taken together, these results suggested that USP36 promotes proliferation and metastasis in CRC through stabilizing RBM28.Next, we evaluated whether USP36/RBM28 exerts its oncogenic effects through the p53 signaling pathway."
39343961
reach
"Furthermore, in GSC cells, knockout of USP36 inhibited the cell proliferation, stemness and tumorigenicity."
38398118
USP36 affects RBM28
1 | 16
USP36 binds RBM28.
1 | 5
USP36 binds RBM28. 6 / 6
1 | 5
reach
"More importantly, endogenous interactions between USP36 and RBM28 were validated in CRC cells (Fig. 2C)."
39343961
reach
"Then, truncated mutant fragments were generated to determine the specific regions responsible for USP36 and RBM28 interaction."
39343961
reach
"To verify the physical interaction between USP36 and RBM28, co-immunoprecipitation (Co-IP) were performed in HEK293T and CRC cells."
39343961
reach
"Mechanistically, USP36 could interact with and stabilize RBM28 via deubiquitination at K162 residue."
39343961
reach
"USP36 interacts with and upregulates RBM28 depending on its deubiquitinase activity."
39343961
biogrid
No evidence text available
36912080
USP36 increases the amount of RBM28.
| 3
USP36 increases the amount of RBM28. 3 / 3
| 3
reach
"Consistently, wild-type(WT) USP36 significantly increased RBM28 protein levels in a dose-dependent manner, whereas catalytic inactive mutant C131A (USP36 ) showed no obvious impact on RBM28 protein levels (Fig. 2H, I)."
39343961
reach
"These findings suggest an interaction between USP36 and RBM28.Next, we proceeded to investigate whether the expression levels of RBM28 are modulated by USP36."
39343961
reach
"However, there were no observable changes in the mRNA levels of RBM28 following USP36 knockdown or overexpression, which suggested that USP36 upregulates RBM28 expression through post-translational regulation (Fig. S2B)."
39343961
USP36 decreases the amount of RBM28.
| 3
USP36 decreases the amount of RBM28. 3 / 3
| 3
reach
"As shown in Fig. 3A, MG132 could reverse RBM28 protein levels caused by USP36 knockdown."
39343961
reach
"Conversely, ectopic overexpression of USP36 , but not USP36 , dramatically decreased the ubiquitination level of RBM28 in LoVo and HEK293T (Fig. 3D, E)."
39343961
reach
"However, there were no observable changes in the mRNA levels of RBM28 following USP36 knockdown or overexpression, which suggested that USP36 upregulates RBM28 expression through post-translational regulation (Fig. S2B)."
39343961
USP36 inhibits RBM28.
| 2
USP36 inhibits RBM28. 2 / 2
| 2
reach
"Considering the stabilizing effect of USP36 on RBM28, we hypothesized whether USP36 inactivates p53 signaling pathway via RBM28."
39343961
reach
"Conversely, USP36 indirectly suppresses p53 by stabilizing RBM28, a transcriptional repressor of the p53 promoter [110]."
40102846
USP36 deubiquitinates RBM28.
| 2
USP36 deubiquitinates RBM28. 2 / 2
| 2
reach
"These results indicate that USP36 stabilizes RBM28 through the prevention of the proteasomal degradation pathway.Since USP36 is a member of the deubiquitinase family, we explored whether USP36 deubiquitylates RBM28."
39343961
reach
"USP36 depletion markedly increased endogenous RBM28 ubiquitination in HCT 116 and RKO cells (Fig. 3C)."
39343961
USP36 activates RBM28.
| 1
USP36 activates RBM28. 1 / 1
| 1
reach
"In addition, Cycloheximide (CHX) chase assay showed that USP36 knockdown accelerated the degradation of RBM28 (Figs."
39343961
USP36 affects PRIMPOL
2 | 3 11
USP36 binds PRIMPOL.
2 | 1 11
USP36 binds PRIMPOL. 10 / 14
2 | 1 11
sparser
"Cancer cells generally have higher replication stress, and the USP36-PrimPol axis might be required to adapt to this stress."
33237263
sparser
"In ovarian cancer tissues, USP36 overexpression is observed to positively correlate with the level of PrimPol expression and poor prognosis, indicating that the USP36-PrimPol axis may play an important regulatory mechanism in the cancer pathogenesis and treatment."
33237263
sparser
"We further confirmed the close interaction between USP36 and PrimPol by proximity ligation assay (PLA)."
33237263
sparser
"Few dots that represent the interaction of USP36 and PrimPol were observed in the nuclei in unstressed cells."
33237263
sparser
"Overall, these results suggest that USP36 interacts with PrimPol at stressed replication forks in cells."
33237263
sparser
"Next, we studied how HU treatment promoted the interaction between USP36 and PrimPol."
33237263
sparser
"On the other hand, in cancer cells, higher expression of USP36 might render cancer cells resistant to replication stress, while lower USP36 level or inhibition of USP36-PrimPol axis might sensitize cancer cells to genotoxic insults."
33237263
sparser
"Next, we tested whether these two lysine residues (K329R and K338R) were essential for the regulation of USP36-PrimPol interaction."
33237263
biogrid
No evidence text available
33237263
biogrid
No evidence text available
33237263
USP36 deubiquitinates PRIMPOL.
| 2
USP36 deubiquitinates PRIMPOL. 2 / 2
| 2
reach
"PrimPol which is deubiquitinated by USP36 increases DNA replication."
37107644
reach
"USP36 deubiquitinates and regulates the stability of PrimPol, a DNA damage-tolerant polymerase (Figure 2D) [108]."
37107644
USP36 affects PARP1
3 | 11 2
USP36 binds PARP1.
3 | 5 2
USP36 binds PARP1. 10 / 10
3 | 5 2
reach
"Additionally, USP36 directly interacts and deubiquitinates PARP1, thereby increasing PARP1 stability and PARP1-dependent apoptosis of cardiomyocytes during doxorubicin-induced and oxidative stress-med[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38278370
sparser
"Based on our results in HEK293T cells, the interaction between USP36 and PARP1 was confirmed by immunoprecipitation in H9C2 cells ( Fig. 3 E)."
38307305
sparser
"To further investigate whether USP36 and PARP1 interact, we overexpressed Myc-tagged human USP36 into HEK293T cells, along with Flag–PARP1."
38307305
reach
"Mechanistically, USP36 physically interacts with poly (ADP-ribose) polymerase 1 (PARP1) to regulate PARP1 stability by inhibiting its ubiquitination."
38785979
biogrid
No evidence text available
34079125
biogrid
No evidence text available
36912080
biogrid
No evidence text available
19615732
reach
"Mechanistically, USP36 physically binds to Poly (ADP-ribose) polymerase 1 (PARP1) and regulates PARP1 stability by inhibiting its ubiquitination, with PARP1 mediating the effect of USP36 on DIC modula[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38307305
reach
"Based on our results in HEK293T cells, the interaction between USP36 and PARP1 was confirmed by immunoprecipitation in H9C2 cells ( Fig. 3 E)."
38307305
reach
"Additionally, we observed that Dox increased the interaction of USP36 and PARP1 using endogenous co-IP experiments in H9C2 cells ( Fig. 3 I)."
38307305
USP36 deubiquitinates PARP1.
| 2
USP36 deubiquitinates PARP1. 2 / 2
| 2
reach
"As shown in Fig. 4 A , overexpression of USP36 WT promoted the deubiquitination of PARP1 and increased the levels of PARP1 in HEK293T cells, while the C131A mutant failed to induce PARP1 level."
38307305
reach
"This investigation provides compelling evidence that USP36 deubiquitinates PARP1, suggesting that the USP36/PARP1 axis is a promising therapeutic target for Dox-induced cardiomyopathy [63] (Figure 2G)."
38785979
USP36 activates PARP1.
| 2
USP36 activates PARP1. 2 / 2
| 2
reach
"Taken together, these results indicated USP36 deficiency alleviated Dox-induced cardiac injury and confirmed the effect of USP36 is mediated, at least in part, by regulating the PARP1 pathway."
38307305
reach
"USP36 modulates the activity of the Hippo/YAP, PRL1/Snail2, c-Myc/SOD2, CEP63/YAP1, Fbw7g/USP36/c-Myc, ERK/AKT ALR (augmentation of liver regeneration)/MDM2, and USP36/PARP1 pathways through interaction with specific components and exertion of deubiquitinating effects (Figure 2)."
38785979
USP36 ubiquitinates PARP1.
| 1
USP36 leads to the ubiquitination of PARP1. 1 / 1
| 1
reach
"We found that knockdown of USP36 increased the reduction of PARP1 ubiquitination stimulated by Dox in H9C2 cells ( Fig. 4 E)."
38307305
USP36 inhibits PARP1.
| 1
USP36 inhibits PARP1. 1 / 1
| 1
reach
"Mechanistically, USP36 targets PARP1 for its deubiquitination and this function can be abolished by the C131A mutant in USP36 [174]."
40102846
USP36 affects Flag
| 16
USP36 binds Flag. 10 / 16
| 16
sparser
"We transfected cells with V5-DGCR8 together with control, Flag-tagged full-length USP36, and a panel of Flag-USP36 deletion mutants followed by co-IP using anti-Flag antibody."
36950067
sparser
"Similarly, co-IP assays using lysates from cells transfected with V5-Drosha in the absence or presence of Flag-USP36 or its deletion mutants showed that Drosha also interacts with both the N-terminus and the C-terminus of USP36 ( xref and xref )."
36950067
sparser
"Also, endogenous DGCR8 and Drosha were immunoprecipitated with Flag-USP36 using anti-Flag antibody ( xref )."
36950067
sparser
"Indeed, exogenously expressed V5-USP36 was co-immunoprecipitated with Flag-DGCR8 and Flag-Drosha ( xref ) and Flag-USP36 co-immunoprecipitates with V5-DGCR8 ( xref ) and V5-Drosha ( xref ) by using anti-Flag antibody in cells."
36950067
sparser
"We transfected cells with Flag-USP36 or/and Flag-Fbw7γ and performed immunoprecipitation with anti-hUTP14a antibody."
30343112
sparser
"Cell fractionation assays also confirmed that the majority of the endogenous Las1L and Nol9 are present in the nucleolar fraction together with Flag-USP36 ( xref )."
39356143
sparser
"Conversely, PrimPol stability was significantly increased in HEK293T cells stably expressing Flag-USP36 ( xref )."
33237263
sparser
"Flag-USP36 and Flag-Fbw7γ co-existed in the hUTP14a-specific immunoprecipitates regardless of MG132 treatment, demonstrating that hUTP14a forms a complex with USP36 and Fbw7γ ( Fig. 3 G)."
30343112
sparser
"Immunofluorescence staining showed that hUTP14a co-localizes with Flag-USP36 and Flag-Fbw7γ in the nucleolus whether cells were treated with MG132 or not ( Fig. 3 H), confirming that hUTP14a interacts[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30343112
sparser
"PrimPol was also detected in immunoprecipitates using anti-Flag agarose beads from cells expressed Flag-USP36 (Figure xref )."
33237263
ALKBH5 affects USP36
4 | 3 9
ALKBH5 binds USP36. 10 / 16
4 | 3 9
sparser
"These findings provide valuable insights into the complex molecular interactions involved in tumor formation and highlight the potential of targeting the USP36-ALKBH5 axis as a therapeutic intervention for glioblastoma."
38785979
sparser
"Subsequent mass spectrometry experiments were conducted to unveil the protein interaction partners of ALKBH5, and the results demonstrated the interaction between USP36 and ALKBH5 [ xref ]."
38398118
sparser
"Another m 6 A modifier, ALKBH5, is stabilized by the deubiquitinase USP36 in GSCs, stimulating tumor growth and TMZ resistance [ xref ], and this USP36–ALKBH5 relationship may provide another targetable scaffold in GSCs."
37444568
sparser
"Mass spectrometry and immunoprecipitation were performed to identify the USP36 and ALKBH5 interaction."
36239338
sparser
"Our findings indicate that USP36 regulates the protein degradation and expression of ALKBH5, and the USP36-ALKBH5 axis orchestrates glioma tumorigenesis."
36239338
sparser
"Together, these findings underscore the crucial role of the USP36–ALKBH5 axis in governing GSC cell proliferation, stemness and tumorigenesis, and could potentially lay the groundwork for progressing the development of more potent therapies targeting glioblastoma [ xref , xref ]. xref illustrates the various regulators and mechanisms for dysregulation of m 6 A-related genes discussed in this sector."
38398118
sparser
"For example, the USP36–ALKBH5 axis has been shown to impart resistance to TMZ, the first-line chemotherapeutic agent for standard practice in the management of glioblastoma [ xref ]."
38398118
sparser
"ALKBH5 deficiency decreased PD‐L1 protein level by suppressing ZDHHC3 mRNA expression in an m 6 A modification manner, further enhancing the efficacy of anti‐PD‐1 therapy for GBM. xref ALKBH5 facilitates hypoxia‐induced paraspeckle assembly and IL8 secretion to recruit tumor‐associated macrophages (TAMs) to promote GBM progression. xref Ubiquitin‐specific peptidase 36 (USP36) interacts with and stabilizes ALKBH5, and targeting USP36‐ALKBH5 axis inhibits cell proliferation and self‐renewal of GSCs and sensitized GSCs to temozolomide (TMZ) treatment. xref It has been reported that ALKBH5 maintains tumorigenicity of GBM stem‐like cells (GSCs) by sustaining FOXM1 mRNA expression and cell proliferation program. xref We also found that ALKBH5 expression was associated with malignant proliferation of GBM and stemness of GSCs, but we focused on the alternative splicing events and isoform switch of target genes rather than mRNA expression."
39974663
sparser
"Subsequent studies have also found that ALKBH5 and USP36 interact to maintain stem cell properties in glioblastoma and promote tumor progression (Chang et al., 2023[ xref ])."
39967906
biogrid
No evidence text available
36239338
USP36 affects apoptotic process
| 14
USP36 inhibits apoptotic process.
| 7
reach
"These data suggest that USP36 knockdown activated extrinsic and intrinsic apoptosis."
38876304
reach
"PI/Annexin V double staining coupled with FACS analysis showed that USP36 depletion enhanced cell apoptosis, which could be partially reversed by further YAP overexpression in KYSE150 cells (Fig. 4L), this conclusion was observed by the western blot of caspase-3(cleaved), which showed that YAP overexpression noticeably decreased caspase-3(cleaved) protein levels (Fig. S3J)."
36470870
reach
"USP36 inhibits apoptosis via the stabilization of survivin and cIAP1."
38876304
reach
"To determine whether USP36 inhibited apoptosis, transient transfection experiments were performed in HCT 116 cells using overexpression of Bax or Fas plasmids as stimuli for inducing intrinsic and extrinsic apoptosis, respectively."
38876304
reach
"Overexpression of USP36 promoted NSCLC cell proliferation and inhibited NSCLC cell apoptosis."
35133629
reach
"Silencing USP36 in cardiac cells mitigated Dox-induced cardiomyocyte apoptosis and cardiac dysfunction."
38307305
reach
"We showed that the knockdown of USP36 induces intrinsic and extrinsic apoptosis."
38876304
USP36 activates apoptotic process.
| 7
USP36 activates apoptotic process. 6 / 6
| 6
reach
"As apoptotic tubular cell death is one of major characteristic features of AKI, we continued to explore whether USP36 play a role in ischemia induced tubular cell apoptosis."
30975468
reach
"The beneficial effects of silencing USP36 on inhibiting oxidative stress and apoptosis in cardiomyocytes are significant."
38307305
reach
"USP36 downregulation can promote intrinsic and extrinsic apoptosis."
38876304
reach
"Annexin V staining revealed that small interfering (si)USP36#1 and siUSP36#2 RNA transfection significantly enhanced cell apoptosis compared to the untreated group (Fig. 2, A and B), which was further confirmed via Western blot analysis of poly-ADP ribose polymerase (PARP) cleavage (Fig. 2, C and D)."
38876304
reach
"In keeping with our finding that JNK signaling upregulates USP36 expression, a combination of HHT with SP600125, a selective inhibitor of JNK, synergistically induced apoptosis, which could be largely rescued by ectopic expression of USP36 (Fig. 6q and Supplementary Fig. S7h)."
37833415
reach
"Moreover, northern blot analysis has shown that USP36 deficiency induces aberrations in rRNA synthesis and apoptosis at the preimplantation stage of development."
33518352
USP36 bound to MYC activates apoptotic process. 1 / 1
| 1
reach
"Both USP28 and USP36 can bind to c-MYC in cells, and deubiquitinize c-MYC, thereby modulating cancer cell growth and apoptosis (Popov et al., 2007; Sun et al., 2015)."
37251574
PRIMPOL affects USP36
2 | 1 11
USP36 binds PRIMPOL. 10 / 14
2 | 1 11
sparser
"Cancer cells generally have higher replication stress, and the USP36-PrimPol axis might be required to adapt to this stress."
33237263
sparser
"In ovarian cancer tissues, USP36 overexpression is observed to positively correlate with the level of PrimPol expression and poor prognosis, indicating that the USP36-PrimPol axis may play an important regulatory mechanism in the cancer pathogenesis and treatment."
33237263
sparser
"We further confirmed the close interaction between USP36 and PrimPol by proximity ligation assay (PLA)."
33237263
sparser
"Few dots that represent the interaction of USP36 and PrimPol were observed in the nuclei in unstressed cells."
33237263
sparser
"Overall, these results suggest that USP36 interacts with PrimPol at stressed replication forks in cells."
33237263
sparser
"Next, we studied how HU treatment promoted the interaction between USP36 and PrimPol."
33237263
sparser
"On the other hand, in cancer cells, higher expression of USP36 might render cancer cells resistant to replication stress, while lower USP36 level or inhibition of USP36-PrimPol axis might sensitize cancer cells to genotoxic insults."
33237263
sparser
"Next, we tested whether these two lysine residues (K329R and K338R) were essential for the regulation of USP36-PrimPol interaction."
33237263
biogrid
No evidence text available
33237263
biogrid
No evidence text available
33237263
USP36 affects SOD2
2 3 1 | 4 3
USP36 binds SOD2.
3 | 3
USP36 binds SOD2. 6 / 6
3 | 3
sparser
"As shown in xref b, USP36 associated with immunoprecipitated SOD2 at 2 h, but not at 4 h, indicating a transient interaction between the two molecules, in line with the transient increase in SOD2 levels."
34207085
sparser
"The study showed that anakinra promotes the binding of SOD2 to the deubiquitinase, ubiquitin specific peptidase 36 (USP36), and constitutive photomorphogenesis 9 (COP9) signalosome, thus increasing SOD2 protein longevity."
36845127
biogrid
No evidence text available
21268071
biogrid
No evidence text available
21268071
biogrid
No evidence text available
21268071
sparser
"Conversely, work in the mouse and human kidney suggests that Usp36 interacts with SOD2 in the mechanism of acute kidney injury due to ischaemia."
38734725
USP36 deubiquitinates SOD2.
1 1 | 1
USP36 deubiquitinates SOD2. 3 / 3
1 1 | 1
ubibrowser
"we identified a deubiquitinating enzyme <span class="match term0">USP36</span> that regulates the protein stability of <span class="match term1">SOD2</span>"
21268071
reach
"USP36 was found to protect renal function by deubiquitinating SOD2 and c-Myc, attenuating oxidative damage, and promoting cell proliferation25."
40225869
signor
"Protein stability of mitochondrial superoxide dismutase SOD2 is regulated by USP36|Finally, USP36 was shown to be a specific deubiquitinating enzyme that reduces the ubiquitination level of SOD2 and was involved in SOD2 protein stability by extending its half-life."
21268071
USP36 increases the amount of SOD2.
1 | 1
USP36 increases the amount of SOD2. 2 / 2
1 | 1
reach
"The in vitro studies also revealed that the overexpression of USP36 restored the deducted SOD2 protein level by ischemia in HK-2 cells ( Fig. 4 C), without changing its mRNA level ( Fig. 4 D), and tha[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30975468
signor
"Protein stability of mitochondrial superoxide dismutase SOD2 is regulated by USP36|Finally, USP36 was shown to be a specific deubiquitinating enzyme that reduces the ubiquitination level of SOD2 and was involved in SOD2 protein stability by extending its half-life."
21268071
USP36 decreases the amount of SOD2.
| 1
USP36 decreases the amount of SOD2. 1 / 1
| 1
reach
"Concurrently, ischemia led to an elevation of ubiqutinated SOD2 levels, which could be effectively abolished by USP36 overexpression, thereby a role of USP36 in AKI associated SOD2 reduction and oxida[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30975468
USP36 activates SOD2.
| 1
USP36 activates SOD2. 1 / 1
| 1
reach
"USP36 modulates the activity of the Hippo/YAP, PRL1/Snail2, c-Myc/SOD2, CEP63/YAP1, Fbw7g/USP36/c-Myc, ERK/AKT ALR (augmentation of liver regeneration)/MDM2, and USP36/PARP1 pathways through interaction with specific components and exertion of deubiquitinating effects (Figure 2)."
38785979
USP36 affects MYCN
1 | 7 5
USP36 binds MYCN.
1 | 5 5
MYCN binds USP36. 10 / 11
1 | 5 5
reach
"Consistent with the endogenous MYCN and USP36 interaction data, ectopically expressed Halo-USP36 was immunoprecipitated with the endogenous MYCN in HeLa cells, further confirming the interaction between MYCN and USP36 (XREF_FIG, right panel)."
34056606
reach
"Considering that the ubiquitin specific protease USP36 enhances the stability of target proteins through the removal of ubiquitin moieties, we thought USP36 interaction with MYCN could be involved in the regulation of MYCN stability via ubiquitin mediated proteasomal degradation."
34056606
sparser
"USP36 Interacts With MYCN and Regulates Its Stability by Deubiquitination."
34056606
sparser
"To further investigate the interaction between USP36 and MYCN, we performed a co-immunoprecipitation (Co-IP) of MYCN to verify its association with USP36 in SK-N-BE(2) and IMR-32 cell lines."
34056606
sparser
"We found that endogenous MYCN interacts with USP36 in both of the cells lines ( xref , left and middle panels)."
34056606
sparser
"Consistent with the endogenous MYCN and USP36 interaction data, ectopically expressed Halo-USP36 was immunoprecipitated with the endogenous MYCN in HeLa cells, further confirming the interaction between MYCN and USP36 ( xref , right panel)."
34056606
sparser
"Considering that the ubiquitin-specific protease USP36 enhances the stability of target proteins through the removal of ubiquitin moieties, we thought USP36 interaction with MYCN could be involved in the regulation of MYCN stability via ubiquitin mediated proteasomal degradation."
34056606
biogrid
No evidence text available
35013218
reach
"To further investigate the interaction between USP36 and MYCN, we performed a co-immunoprecipitation (Co-IP) of MYCN to verify its association with USP36 in SK-N-BE (2) and IMR-32 cell lines."
34056606
reach
"We found that endogenous MYCN interacts with USP36 in both of the cells lines (XREF_FIG, left and middle panels)."
34056606
USP36 increases the amount of MYCN.
| 1
USP36 increases the amount of MYCN. 1 / 1
| 1
reach
"These results strongly suggest that USP36 positively regulates MYCN protein levels."
34056606
USP36 deubiquitinates MYCN.
| 1
USP36 deubiquitinates MYCN. 1 / 1
| 1
reach
"These results indicate that USP36 interacts with and deubiquitinates MYCN, thereby promoting the stability of MYCN."
34056606
USP36 affects DOCK4
3 | 8 2
USP36 binds DOCK4.
3 | 1 2
USP36 binds DOCK4. 6 / 6
3 | 1 2
biogrid
No evidence text available
33968925
reach
"To elucidate the interaction between DOCK4 and USP36, immunoprecipitation and Duolink proximity ligation assay were employed (Figures 4B,C)."
33968925
sparser
"First, we evidenced that USP36 physically interacts with DOCK4 by IP and in situ proximity ligation assay ( in situ PLA) ( xref )."
33968925
sparser
"To elucidate the interaction between DOCK4 and USP36, immunoprecipitation and Duolink proximity ligation assay were employed ( xref )."
33968925
biogrid
No evidence text available
33968925
biogrid
No evidence text available
33968925
USP36 deubiquitinates DOCK4.
| 5
USP36 deubiquitinates DOCK4. 5 / 5
| 5
reach
"USP36 deubiquitinates the dedicator of cytokinesis 4 (DOCK4), as evidenced by the up- or downregulation of Usp36 in TECs in response to overexpression or knockdown, respectively [144]."
36834633
reach
"Further investigation into the mechanisms proved that USP36 could directly bind to and mediate the deubiquitination of dedicator of cytokinesis 4 (DOCK4), a guanine nucleotide exchange factor (GEF) that could activate Wnt/beta-catenin signaling pathway and induce EMT."
33968925
reach
"Further, we found that USP36 could directly bind to and mediate the deubiquitination of dedicator of cytokinesis 4 (DOCK4), a guanine nucleotide exchange factor (GEF) that could activate Wnt/β-catenin signaling pathway and induce EMT."
33968925
reach
"USP36 contributes to DN progression by directly deubiquitinating cytokinin 4 (DOCK4) and aggravating guanine nucleotide exchange factor (GEF)-mediated EMT (136) ( Table 9 ).2.8.5 Roles of USPs in diabetic neuropathic pain."
38322269
reach
"Additionally, USP36 directly bound to and mediated the de-ubiquitination of DOCK4, whereas DOCK4 knockdown effectively abolished EMT induced by USP36 overexpression through suppressing Wnt/β-catenin signaling in TECs (Zhu et al., 2021)."
35082683
USP36 increases the amount of DOCK4.
| 2
USP36 increases the amount of DOCK4. 2 / 2
| 2
reach
"To study the effect of USP36 on the expression of DOCK4, we evidenced the protein level of DOCK4 was significantly reduced or elevated by knockdown or overexpression of USP36 in TECs (Figures 4E,F)."
33968925
reach
"Then, the data showed that the ubiquitination level of DOCK4 was significantly increased or decreased by knockdown or overexpression of USP36 in TECs (Figures 4G–J)."
33968925
USP36 affects NPPA
| 11
NPPA binds USP36. 10 / 11
| 11
sparser
"The current method was adapted from literature ( Parry et al., 1992 ), and was validated per USP guideline ( USP36-NF31, 2013 )."
26241753
sparser
"These values are in compliance with the USP acceptance criteria (85–120%) for the assay of estradiol TDDS ( USP36-NF31, 2013b )."
25311180
sparser
"This was carried out as per the procedure described in USP ( USP36-NF31, 2013a )."
25089511
sparser
"Immersion cell model A (exposed area of 2 cm 2 ; Agilent Technologies, USA) was used with USP apparatus 2 to determine the in vitro release of acyclovir from DOE formulations as per the procedure desc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25089511
sparser
"The cumulative amount of drug dissolved per cm 2 of exposed membrane area was plotted against square root of time (Higuchi plot) to determine the in vitro release rate (slope of Higuchi plot) of acycl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25089511
sparser
"The HPLC analytical method was validated according to USP Validation of Compendial Methods ( USP36-NF31, 2013c )."
25089511
sparser
"Because outliers are expected to occur on occasion with in vitro drug release testing (for example, due to an air bubble between the product sample and the membrane), a nonparametric statistical techn[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25089511
sparser
"The HPLC analytical method was validated according to USP Validation of Compendial Methods ( USP36-NF31, 2013a )."
25311180
sparser
"The extraction solvent (acetonitrile, methanol and water in the ratio of 45:5:50) was almost the same as recommended in USP (acetonitrile and water in the ratio of 50:50) for the assay of estradiol ( [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25311180
sparser
"When tested for drug content uniformity, all the formulations including Zovirax ® complied with USP specifications ( USP36-NF31, 2013c )."
25089511
USP36 affects DROSHA
2 | 5 4
USP36 binds DROSHA.
2 | 3 4
DROSHA binds USP36. 9 / 9
2 | 3 4
reach
"It is likely that SUMOylation of DGCR8 may induce confirmational changes that favor the microprocessor complex targeting of pri-miRNAs and thus increase the activity of Drosha-mediated processing of the pri-miRNAs.Our binding domain mapping results reveal that USP36 binds to DGCR8 and Drosha via distinct domains, suggesting that the three proteins form a multiprotein complex."
36950067
sparser
"Similarly, co-IP assays using lysates from cells transfected with V5-Drosha in the absence or presence of Flag-USP36 or its deletion mutants showed that Drosha also interacts with both the N-terminus and the C-terminus of USP36 ( xref and xref )."
36950067
sparser
"Interestingly, the N-terminus of USP36 binds to Drosha stronger than the C-terminus (compare lane 6 with lane 4; xref )."
36950067
sparser
"Knockdown of DGCR8 also did not reduce the interaction of USP36 with Drosha ( xref ; xref )."
36950067
sparser
"Both DGCR8 and Drosha can bind to the N-terminus and C-terminus of USP36 albeit DGCR8 binds strongly to the C-terminus of USP36 whereas Drosha binds strongly to the N-terminus of USP36."
36950067
biogrid
No evidence text available
36950067
biogrid
No evidence text available
36950067
reach
"Interestingly, the N-terminus of USP36 binds to Drosha stronger than the C-terminus (compare lane 6 with lane 4; Fig. 3C)."
36950067
reach
"To examine where USP36 binds to Drosha and DGCR8, we also performed co-IP and IB experiments using a panel of Flag-DGCR8 mutants (Fig. 3E and F) and Flag-Drosha mutants (Fig. 3G and H)."
36950067
USP36 increases the amount of DROSHA.
| 2
USP36 increases the amount of DROSHA. 2 / 2
| 2
reach
"As shown in Fig. 4A, overexpression of USP36 did not increase the levels of DGCR8 and Drosha in multiple tested cell lines."
36950067
reach
"Also, knockdown of USP36 by siRNA (Fig. 4B) or lentiviral-encoded shRNA (Fig. 4C) did not reduce the levels of DGCR8 and Drosha."
36950067
NPPA affects USP36
| 11
NPPA binds USP36. 10 / 11
| 11
sparser
"The current method was adapted from literature ( Parry et al., 1992 ), and was validated per USP guideline ( USP36-NF31, 2013 )."
26241753
sparser
"These values are in compliance with the USP acceptance criteria (85–120%) for the assay of estradiol TDDS ( USP36-NF31, 2013b )."
25311180
sparser
"This was carried out as per the procedure described in USP ( USP36-NF31, 2013a )."
25089511
sparser
"Immersion cell model A (exposed area of 2 cm 2 ; Agilent Technologies, USA) was used with USP apparatus 2 to determine the in vitro release of acyclovir from DOE formulations as per the procedure desc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25089511
sparser
"The cumulative amount of drug dissolved per cm 2 of exposed membrane area was plotted against square root of time (Higuchi plot) to determine the in vitro release rate (slope of Higuchi plot) of acycl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25089511
sparser
"The HPLC analytical method was validated according to USP Validation of Compendial Methods ( USP36-NF31, 2013c )."
25089511
sparser
"Because outliers are expected to occur on occasion with in vitro drug release testing (for example, due to an air bubble between the product sample and the membrane), a nonparametric statistical techn[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25089511
sparser
"The HPLC analytical method was validated according to USP Validation of Compendial Methods ( USP36-NF31, 2013a )."
25311180
sparser
"The extraction solvent (acetonitrile, methanol and water in the ratio of 45:5:50) was almost the same as recommended in USP (acetonitrile and water in the ratio of 50:50) for the assay of estradiol ( [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25311180
sparser
"When tested for drug content uniformity, all the formulations including Zovirax ® complied with USP specifications ( USP36-NF31, 2013c )."
25089511
MYCN affects USP36
1 | 5 5
MYCN binds USP36. 10 / 11
1 | 5 5
reach
"Consistent with the endogenous MYCN and USP36 interaction data, ectopically expressed Halo-USP36 was immunoprecipitated with the endogenous MYCN in HeLa cells, further confirming the interaction between MYCN and USP36 (XREF_FIG, right panel)."
34056606
reach
"Considering that the ubiquitin specific protease USP36 enhances the stability of target proteins through the removal of ubiquitin moieties, we thought USP36 interaction with MYCN could be involved in the regulation of MYCN stability via ubiquitin mediated proteasomal degradation."
34056606
sparser
"USP36 Interacts With MYCN and Regulates Its Stability by Deubiquitination."
34056606
sparser
"To further investigate the interaction between USP36 and MYCN, we performed a co-immunoprecipitation (Co-IP) of MYCN to verify its association with USP36 in SK-N-BE(2) and IMR-32 cell lines."
34056606
sparser
"We found that endogenous MYCN interacts with USP36 in both of the cells lines ( xref , left and middle panels)."
34056606
sparser
"Consistent with the endogenous MYCN and USP36 interaction data, ectopically expressed Halo-USP36 was immunoprecipitated with the endogenous MYCN in HeLa cells, further confirming the interaction between MYCN and USP36 ( xref , right panel)."
34056606
sparser
"Considering that the ubiquitin-specific protease USP36 enhances the stability of target proteins through the removal of ubiquitin moieties, we thought USP36 interaction with MYCN could be involved in the regulation of MYCN stability via ubiquitin mediated proteasomal degradation."
34056606
biogrid
No evidence text available
35013218
reach
"To further investigate the interaction between USP36 and MYCN, we performed a co-immunoprecipitation (Co-IP) of MYCN to verify its association with USP36 in SK-N-BE (2) and IMR-32 cell lines."
34056606
reach
"We found that endogenous MYCN interacts with USP36 in both of the cells lines (XREF_FIG, left and middle panels)."
34056606
USP36 affects DHX33
1 8 1 |
USP36 binds DHX33.
8 |
USP36 binds DHX33. 8 / 8
8 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
biogrid
No evidence text available
33961781
biogrid
No evidence text available
19615732
biogrid
No evidence text available
35271311
biogrid
No evidence text available
36912080
biogrid
No evidence text available
29273634
biogrid
No evidence text available
29273634
USP36 deubiquitinates DHX33.
1 1 |
USP36 deubiquitinates DHX33. 2 / 2
1 1 |
ubibrowser
"Collectively, these results support that <span class="match term0">Usp36</span> is essential for cell and organism viability because of its role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, by regulating <span class="match term1">DHX33</span> stability."
29273634
signor
"Loss of the deubiquitinase USP36 destabilizes the RNA helicase DHX33 and causes preimplantation lethality in mice."
29273634
USP36 affects BIRC5
| 8 2
USP36 binds BIRC5.
| 1 2
BIRC5 binds USP36. 3 / 3
| 1 2
sparser
"Therefore, a peptide including the C131 residue of the USP36 sequence might block the interaction between survivin and USP36."
38876304
sparser
"Structural determinants of USP36–cIAP1 and USP36–survivin interactions."
38876304
reach
"Therefore, a peptide including the C131 residue of the USP36 sequence might block the interaction between survivin and USP36."
38876304
USP36 ubiquitinates BIRC5.
| 2
USP36 ubiquitinates BIRC5. 2 / 2
| 2
reach
"Compared to K63R linkage ubiquitin (Fig. 7D, lane 3), K48R disrupted the targeting of survivin to degradation (Fig. 7D, lane 1), and USP36 showed no effect on the ubiquitination of survivin conjugated with K48R ubiquitin chains (Fig. 7D, lane 2)."
38876304
reach
"USP36 inhibits apoptosis by deubiquitinating cIAP1 and survivin in colorectal cancer cells."
38876304
USP36 increases the amount of BIRC5.
| 2
USP36 increases the amount of BIRC5. 2 / 2
| 2
reach
"Overexpression of USP36 increased the protein levels of endogenous cIAP1 and survivin in HEK-293 cells (Fig. 6A), whereas no discernible increase in the mRNA levels was observed."
38876304
reach
"To assess whether USP36 modulates the endogenous levels of cIAP1 and survivin proteins, we performed transient transfection in HEK-293 cells."
38876304
USP36 deubiquitinates BIRC5.
| 2
USP36 leads to the deubiquitination of BIRC5. 2 / 2
| 2
reach
"The expression of USP36 still blocked the ubiquitination and degradation of survivin (Fig. 7E, lane 4)."
38876304
reach
"Given that USP36 mediates the deubiquitination of cIAP1 and survivin, we tested the ability of USP36 to cleave different types of polyubiquitin chains."
38876304
USP36 decreases the amount of BIRC5.
| 1
USP36 decreases the amount of BIRC5. 1 / 1
| 1
reach
"Although less efficient than siRNA treatments, USP36 knockdown reduced cIAP1 and survivin levels and induced apoptosis (Fig. 8A, lane 4)."
38876304
PARP1 affects USP36
3 | 5 2
USP36 binds PARP1. 10 / 10
3 | 5 2
reach
"Additionally, USP36 directly interacts and deubiquitinates PARP1, thereby increasing PARP1 stability and PARP1-dependent apoptosis of cardiomyocytes during doxorubicin-induced and oxidative stress-med[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38278370
sparser
"Based on our results in HEK293T cells, the interaction between USP36 and PARP1 was confirmed by immunoprecipitation in H9C2 cells ( Fig. 3 E)."
38307305
sparser
"To further investigate whether USP36 and PARP1 interact, we overexpressed Myc-tagged human USP36 into HEK293T cells, along with Flag–PARP1."
38307305
reach
"Mechanistically, USP36 physically interacts with poly (ADP-ribose) polymerase 1 (PARP1) to regulate PARP1 stability by inhibiting its ubiquitination."
38785979
biogrid
No evidence text available
34079125
biogrid
No evidence text available
36912080
biogrid
No evidence text available
19615732
reach
"Mechanistically, USP36 physically binds to Poly (ADP-ribose) polymerase 1 (PARP1) and regulates PARP1 stability by inhibiting its ubiquitination, with PARP1 mediating the effect of USP36 on DIC modula[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38307305
reach
"Based on our results in HEK293T cells, the interaction between USP36 and PARP1 was confirmed by immunoprecipitation in H9C2 cells ( Fig. 3 E)."
38307305
reach
"Additionally, we observed that Dox increased the interaction of USP36 and PARP1 using endogenous co-IP experiments in H9C2 cells ( Fig. 3 I)."
38307305
DGCR8 affects USP36
4 | 2 4
DGCR8 binds USP36. 10 / 10
4 | 2 4
reach
"To examine where USP36 binds to Drosha and DGCR8, we also performed co-IP and IB experiments using a panel of Flag-DGCR8 mutants (Fig. 3E and F) and Flag-Drosha mutants (Fig. 3G and H)."
36950067
reach
"It is likely that SUMOylation of DGCR8 may induce confirmational changes that favor the microprocessor complex targeting of pri-miRNAs and thus increase the activity of Drosha-mediated processing of the pri-miRNAs.Our binding domain mapping results reveal that USP36 binds to DGCR8 and Drosha via distinct domains, suggesting that the three proteins form a multiprotein complex."
36950067
biogrid
No evidence text available
34188037
sparser
"As shown in xref , knockdown of Drosha did not abolish the interaction of USP36 with DGCR8."
36950067
biogrid
No evidence text available
36912080
sparser
"Similarly, DGCR8 SUMOylation by USP36 does not affect the DGCR8-Drosha microprocessor complex formation but promotes DGCR8 binding to pri-miRNAs, suggesting that SUMOylation of DGCR8 by USP36 increases its affinity to pri-miRNAs."
36950067
sparser
"As show in xref , USP36 interacts with the C-terminus region of DGCR8 that contains two dsRBD domains."
36950067
biogrid
No evidence text available
36950067
biogrid
No evidence text available
36950067
sparser
"Both DGCR8 and Drosha can bind to the N-terminus and C-terminus of USP36 albeit DGCR8 binds strongly to the C-terminus of USP36 whereas Drosha binds strongly to the N-terminus of USP36."
36950067
USP36 affects autophagy
| 8 1
USP36 inhibits autophagy. 9 / 9
| 8 1
reach
"Therefore, USP36 inhibits the selective autophagy of protein aggregates at an early stage by removing the ubiquitin signal."
26445063
sparser
"Therefore, USP36 inhibits the selective autophagy of protein aggregates at an early stage by removing the ubiquitin signal."
26445063
reach
"USP36 seems to antagonize different autophagy related processes in a context dependent manner."
26445063
reach
"On the contrary, silencing of USP36 triggered autophagy via a p62 dependent pathway."
28350092
reach
"As the above study revealed, USP36 promoted the cell proliferation and inhibited autophagy, while inhibiting autophagy have no impact on the cell proliferation."
28350092
reach
"Although USP36 is not involved in mTOR pathway, loss of USP36 function activates autophagy ( Taillebourg et al., 2012 )."
32470641
reach
"Loss of Usp36 function autonomously activates autophagy ."
38734725
reach
"A prior study revealed that silencing of USP36, one of the deubiquitinating enzymes, could trigger selective autophagy via a p62 dependent pathway."
28350092
reach
"The deletion of USP36 of Drosophila melanogaster results in an inhibition of larval growth and activated constitutively autophagy in an mTOR independent manner."
26445063
USP36 affects Neoplasms
| 1 8
USP36 activates Neoplasms. 9 / 9
| 1 8
reach
"The xenograft model demonstrated that USP36 depletion significantly reduced ESCC tumor growth in vivo (Figs."
36470870
reach
"Subsequent studies have also found that ALKBH5 and USP36 interact to maintain stem cell properties in glioblastoma and promote tumor progression (Chang et al., 2023[14])."
39967906
reach
"The xenograft model showed that USP36 overexpression significantly promoted ESCC tumor growth in vivo (Figs."
36470870
reach
"These effects are mediated by METTL3 induction of N6-methyladenosine (m A) modifications.Another m A modifier, ALKBH5, is stabilized by the deubiquitinase USP36 in GSCs, stimulating tumor growth and TMZ resistance [193], and this USP36–ALKBH5 relationship may provide another targetable scaffold in GSCs."
37444568
reach
"Furthermore, in vivo xenograft tumor assays revealed that RBM28 silencing exhibited smaller tumors and reversed the promoted tumor growth induced by USP36 expression, as observed in alterations in tumor volume, weight, and Ki67 levels (Fig. 8A, B)."
39343961
reach
"USP36 contributes to the tumor stemness, growth, Oxa-resistance, and metastasis of colon cancer in xenograft models."
38517383
reach
"In the xenograft mouse model, USP36 depletion inhibited tumor growth, and this effect was reversed by YAP overexpression in KYSE150 cells (Figs."
36470870
eidos
"Depletion of USP36 significantly reduced the tumor weight , tumor volume and Ki67 staining , indicating that USP36 harbors oncogenic properties ( Figure 3C and D ) ."
34056606
reach
"In summary, overexpression of USP36 in NSCLC accelerated tumor growth through upregulation of KHK-A, which was medicated by stabilizing c-MYC to increase hnRNPH1/H2 expression."
35133629
USP36 affects NOP58
3 | 3 3
USP36 sumoylates NOP58.
| 3 3
USP36 leads to the sumoylation of NOP58. 6 / 6
| 3 3
sparser
"Research indicates that USP36 augments the SUMOylation of small nucleolar ribonucleoprotein (snoRNP) components Nop58 and Nhp2, thereby enhancing their binding affinity to snoRNAs."
38785979
sparser
"We show that USP36 promotes the SUMOylation of the small nucleolar ribonucleoprotein (snoRNP) components Nop58 and Nhp2 in cells and in vitro and their binding to snoRNAs."
33852194
reach
"We show that USP36 promotes the SUMOylation of the small nucleolar ribonucleoprotein (snoRNP) components Nop58 and Nhp2 in cells and in vitro and their binding to snoRNAs."
33852194
reach
"Research indicates that USP36 augments the SUMOylation of small nucleolar ribonucleoprotein (snoRNP) components Nop58 and Nhp2, thereby enhancing their binding affinity to snoRNAs."
38785979
sparser
"The deubiquitinase USP36 promotes SUMOylation of NOP56 and NOP58 and promotes binding of NOP58 to snoRNA, and knockout of deubiquitinase USP36 significantly inhibits rRNA processing ( xref )."
36741964
reach
"The deubiquitinase USP36 promotes SUMOylation of NOP56 and NOP58 and promotes binding of NOP58 to snoRNA, and knockout of deubiquitinase USP36 significantly inhibits rRNA processing (20)."
36741964
USP36 binds NOP58.
3 |
USP36 binds NOP58. 3 / 3
3 |
biogrid
No evidence text available
33852194
biogrid
No evidence text available
33852194
biogrid
No evidence text available
36912080
DROSHA affects USP36
2 | 3 4
DROSHA binds USP36. 9 / 9
2 | 3 4
reach
"It is likely that SUMOylation of DGCR8 may induce confirmational changes that favor the microprocessor complex targeting of pri-miRNAs and thus increase the activity of Drosha-mediated processing of the pri-miRNAs.Our binding domain mapping results reveal that USP36 binds to DGCR8 and Drosha via distinct domains, suggesting that the three proteins form a multiprotein complex."
36950067
sparser
"Similarly, co-IP assays using lysates from cells transfected with V5-Drosha in the absence or presence of Flag-USP36 or its deletion mutants showed that Drosha also interacts with both the N-terminus and the C-terminus of USP36 ( xref and xref )."
36950067
sparser
"Interestingly, the N-terminus of USP36 binds to Drosha stronger than the C-terminus (compare lane 6 with lane 4; xref )."
36950067
sparser
"Knockdown of DGCR8 also did not reduce the interaction of USP36 with Drosha ( xref ; xref )."
36950067
sparser
"Both DGCR8 and Drosha can bind to the N-terminus and C-terminus of USP36 albeit DGCR8 binds strongly to the C-terminus of USP36 whereas Drosha binds strongly to the N-terminus of USP36."
36950067
biogrid
No evidence text available
36950067
biogrid
No evidence text available
36950067
reach
"Interestingly, the N-terminus of USP36 binds to Drosha stronger than the C-terminus (compare lane 6 with lane 4; Fig. 3C)."
36950067
reach
"To examine where USP36 binds to Drosha and DGCR8, we also performed co-IP and IB experiments using a panel of Flag-DGCR8 mutants (Fig. 3E and F) and Flag-Drosha mutants (Fig. 3G and H)."
36950067
YAP1 affects USP36
| 2 6
USP36 binds YAP1. 7 / 7
| 1 6
sparser
"USP36 interacts with YAP and inhibits YAP polyubiquitination and breakdown, which further promotes esophageal cancer progression (Fig. xref )."
36470870
sparser
"USP36 could associate with YAP and deubiquitinate YAP protein, which further leads to enhanced Hippo/YAP activity."
36470870
sparser
"Molecular studies demonstrated that USP36 associated with the YAP protein and enhanced YAP protein stability by blocking the K48-linked polyubiquitination of YAP."
36470870
sparser
"USP36 could interact with the YAP protein and inhibit YAP K48-linked polyubiquitination."
36470870
reach
"USP36 could associate with YAP and deubiquitinate YAP protein, which further leads to enhanced Hippo/YAP activity."
36470870
sparser
"These findings indicate that USP36 interacts with YAP and plays a role in deubiquitinating YAP, thereby positively influencing Hippo/YAP signaling activity."
38785979
sparser
"We made deletion constructs targeting these domains for interaction analysis, which revealed that the WW domain was necessary for the binding of YAP to USP36, while the USP domain was required for the association of USP36 with YAP (Fig. xref )."
36470870
YAP1 binds USP36 and USP domain. 1 / 1
| 1
reach
"We made deletion constructs targeting these domains for interaction analysis, which revealed that the WW domain was necessary for the binding of YAP to USP36, while the USP domain was required for the association of USP36 with YAP (Fig. 5E, F)."
36470870
USP36 affects TP53
| 8
USP36 inhibits TP53.
| 7
USP36 inhibits TP53. 7 / 7
| 7
reach
"Collectively, these results indicated that USP36 inhibits p53 transcriptional activity and negatively regulates p53 signaling pathway."
39343961
reach
"Conversely, USP36 indirectly suppresses p53 by stabilizing RBM28, a transcriptional repressor of the p53 promoter [110]."
40102846
reach
"RBM28 is required for USP36-mediated inhibition of p53 transcriptional activity."
39343961
reach
"Given the stabilizing impact of USP36 on RBM28-mediated p53 inhibition and the function of p53 in tumorigenesis, we evaluated the biological role of USP36 in CRC."
39343961
reach
"USP36 inhibits p53 signaling pathway by impairing p53 transcriptional activity."
39343961
reach
"Further, luciferase reporter assays indicated that p53 transcriptional activity was augmented by USP36 silencing in HCT 116 and RKO cells, which was restored by pifithrin-α (PFT-α, a p53-specific inhibitor) (Figs."
39343961
reach
"Chromatin immunoprecipitation (ChIP) assays also showed that USP36 knockdown enhanced the ability of p53 to bind to the promoters of its canonical downstream genes, such as p21 and BAX, whereas USP36 overexpression exhibited an opposite effect (Fig. 1E, F)."
39343961
USP36 activates TP53.
| 1
USP36 activates TP53. 1 / 1
| 1
reach
"Given the stabilizing impact of USP36 on RBM28-mediated p53 inhibition and the function of p53 in tumorigenesis, we evaluated the biological role of USP36 in CRC."
39343961
USP36 affects LAS1L
1 | 2 5
USP36 sumoylates LAS1L.
| 2 3
USP36 sumoylates LAS1L. 4 / 4
| 1 3
reach
"USP36 SUMOylates Las1L and Promotes Its Function in Pre-Ribosomal RNA ITS2 Processing."
39356143
sparser
"We therefore examined whether USP36 promotes Las1L SUMOylation."
39356143
sparser
"Therefore, our results suggest that SUMOylation of Las1L by USP36 promotes Las1L function in pre-rRNA ITS2 processing and thus ribosome biogenesis."
39356143
sparser
"USP36 promotes Las1L SUMOylation."
39356143
USP36 leads to the sumoylation of LAS1L on lysine. 1 / 1
| 1
reach
"Intriguingly, USP36 also mediates the SUMOylation of Las1L, mainly at lysine (K) 565."
39356143
USP36 binds LAS1L.
1 | 2
USP36 binds LAS1L. 3 / 3
1 | 2
sparser
"We also confirmed that endogenous USP36 interacts with endogenous Las1L ( xref )."
39356143
biogrid
No evidence text available
36912080
sparser
"We showed that USP36 interacts with the rixosome components and that abrogating Las1L SUMOylation by the K565R mutation attenuated Las1L’s interaction with the pre-60S ribosome, suggesting that USP36 may regulate Las1L SUMOylation and 60S ribosome biogenesis in the context of the rixosome."
39356143
USP36 affects FBXW7
2 | 4 1
USP36 binds FBXW7.
2 | 2 1
FBXW7 binds USP36. 5 / 6
2 | 2 1
biogrid
No evidence text available
25775507
sparser
"Usp28 preferentially binds the Fbw7α isoform, whereas Usp36 selectively associates with Fbw7γ and both DUBs stabilize Myc."
26459133
reach
"USP28 and USP37 stabilize c-Myc in the nucleus [ 18 , 19 ], while USP36 interacts with Fbw7γ in the nucleolus and abolishes Fbw7γ- and Fbw7α-mediated c-Myc degradation [ 20 ]."
30343112
reach
"For example, USP28 and USP36 interact with FBW7 and reverse FBW7-mediated c-Myc degradation ( Popov et al., 2007 ; Sun et al., 2015 )."
34102342
biogrid
No evidence text available
25775507
USP36 inhibits FBXW7.
| 2
USP36 inhibits FBXW7. 2 / 2
| 2
reach
"Finally, Fbw7 activity is antagonized by the ubiquitin-specific proteases Usp28 and Usp36, which may be readily amenable to inhibition with small molecules."
26459133
reach
"In contrast, Fbw7-associated DUBs have the potential to antagonize ubiquitination of multiple substrates.Fbw7-mediated degradation of Myc is antagonized by Usp28 and Usp36 [99,100] ."
26459133
USP36 affects BIRC2
| 7 1
USP36 increases the amount of BIRC2.
| 4
USP36 increases the amount of BIRC2. 4 / 4
| 4
reach
"To assess whether USP36 modulates the endogenous levels of cIAP1 and survivin proteins, we performed transient transfection in HEK-293 cells."
38876304
reach
"Overexpression of USP36 increased the protein levels of endogenous cIAP1 and survivin in HEK-293 cells (Fig. 6A), whereas no discernible increase in the mRNA levels was observed."
38876304
reach
"In HCT 116 cells, the overexpression of USP36 also increased the protein levels of cIAP1 (Fig. 6D, left panels) and survivin (Fig. 6E, left panels), with a mild effect on the mRNA levels (Fig. 6, D and E, right panels)."
38876304
reach
"Although less efficient than siRNA treatments, USP36 knockdown reduced cIAP1 and survivin levels and induced apoptosis (Fig. 8A, lane 4)."
38876304
USP36 deubiquitinates BIRC2.
| 2
USP36 leads to the deubiquitination of BIRC2. 2 / 2
| 2
reach
"WT USP36 reduced cIAP1 ubiquitination (Fig. 6G, lane 2)."
38876304
reach
"Given that USP36 mediates the deubiquitination of cIAP1 and survivin, we tested the ability of USP36 to cleave different types of polyubiquitin chains."
38876304
USP36 inhibits BIRC2.
| 1
USP36 inhibits BIRC2. 1 / 1
| 1
reach
"USP36 inhibits apoptosis via the stabilization of survivin and cIAP1."
38876304
USP36 binds BIRC2.
| 1
BIRC2 binds USP36. 1 / 1
| 1
sparser
"Structural determinants of USP36–cIAP1 and USP36–survivin interactions."
38876304
DHX33 affects USP36
8 |
USP36 binds DHX33. 8 / 8
8 |
biogrid
No evidence text available
28514442
biogrid
No evidence text available
26186194
biogrid
No evidence text available
33961781
biogrid
No evidence text available
19615732
biogrid
No evidence text available
35271311
biogrid
No evidence text available
36912080
biogrid
No evidence text available
29273634
biogrid
No evidence text available
29273634
USP36 affects NOP56
3 | 2 2
USP36 sumoylates NOP56.
| 2 2
USP36 leads to the sumoylation of NOP56. 4 / 4
| 2 2
reach
"Furthermore, USP36 also promotes the SUMOylation of snoRNP components Nop56 and DKC1."
38785979
sparser
"The deubiquitinase USP36 promotes SUMOylation of NOP56 and NOP58 and promotes binding of NOP58 to snoRNA, and knockout of deubiquitinase USP36 significantly inhibits rRNA processing ( xref )."
36741964
sparser
"Furthermore, USP36 also promotes the SUMOylation of snoRNP components Nop56 and DKC1."
38785979
reach
"The deubiquitinase USP36 promotes SUMOylation of NOP56 and NOP58 and promotes binding of NOP58 to snoRNA, and knockout of deubiquitinase USP36 significantly inhibits rRNA processing (20)."
36741964
USP36 binds NOP56.
3 |
NOP56 binds USP36. 3 / 3
3 |
biogrid
No evidence text available
33852194
biogrid
No evidence text available
34079125
biogrid
No evidence text available
36912080
WDR5 affects USP36
2 | 4
WDR5 binds USP36. 6 / 6
2 | 4
sparser
"Indeed, co-IP experiment results revealed an interaction between USP36 and WDR5 in hFOB1.19 cells (Fig.  xref A)."
39152465
biogrid
No evidence text available
33022573
sparser
"This suggests a vital role of c-MYC in mediating the influence of the USP36-WDR5 axis on osteoblast activities."
39152465
biogrid
No evidence text available
36912080
sparser
"USP36 interacts with WD repeat-containing protein 5 (WDR5), and the knockdown of USP36 causes an increased level of WDR5 ubiquitination and accelerated degradation of WDR5."
39152465
sparser
"USP36 interacts with WDR5 and regulates its ubiquitination."
39152465
USP36 affects Ubiquitin
| 6
USP36 inhibits Ubiquitin.
| 5
USP36 inhibits Ubiquitin. 5 / 5
| 5
reach
"Therefore, USP36 inhibits the selective autophagy of protein aggregates at an early stage by removing the ubiquitin signal."
26445063
reach
"Recent studies have demonstrated that ubiquitin-mediated degradation of c-Myc was inhibited by USPs including USP28, USP37, and USP36 [ 18–20 ]."
30343112
reach
"USP36 expression reduced the ubiquitin linkage on survivin induced by different nocodazole concentrations (Fig. 6H, lanes 2 and 4)."
38876304
reach
"Given its distinct localization (USP36 is the only active DUB localized to the nucleolus ), it is conceivable that USP36 antagonizes post-translational modifications of Ubiquitin, Fubi, and ISG15 in this organelle."
37712884
reach
"Similarly, our data showed that USP36 interacted with c-Myc, and overexpression of USP36 significantly blocked ubiquitin-mediated degradation of c-Myc in HCT116 cells."
38517383
USP36 activates Ubiquitin.
| 1
USP36 activates Ubiquitin. 1 / 1
| 1
reach
"Ten years after the initial GWAS, we now have a better mechanistic understanding of this genetic predisposition as CASC15 and NBAT-1 were shown to modulate the localization of the Ubiquitin-Specific Protease 36 (USP36) [87]."
30200332
reach
"In the in vivo metastasis assay, USP36 overexpression significantly enhanced the lung metastasis of ECA109 cells (Fig. 4I)."
36470870
reach
"In the in vivo metastasis assay, USP36 depletion significantly reduced lung metastasis in ECA109 cells (Fig. 3I)."
36470870
reach
"Our previous study clarified that ubiquitin-specific peptidase 36 (USP36) accelerates ESCC proliferation and metastasis through stabilizing YAP protein [13]."
38906857
reach
"USP36 contributes to the tumor stemness, growth, Oxa-resistance, and metastasis of colon cancer in xenograft models."
38517383
reach
"Taken together, these results suggested that USP36 promotes proliferation and metastasis in CRC through stabilizing RBM28.Next, we evaluated whether USP36/RBM28 exerts its oncogenic effects through the p53 signaling pathway."
39343961
reach
"The analysis on liver metastasis murine revealed that the overexpression of USP36 caused a promotion of the liver metastasis of HCT116 cells (Figure 3F)."
38517383
USP36 activates Neoplasm Invasiveness. 6 / 6
| 6
reach
"USP36 promotes CRC cell proliferation, migration, and invasion in vitro."
39343961
reach
"The transwell assay demonstrated that USP36 overexpression could further promote the migration and invasion of ECA109 cells (Fig. 4D)."
36470870
reach
"Subsequently, USP36 silencing was shown to suppress migration and invasion in HCT 116 and RKO cells, as evidenced by transwell and wound healing assays, while its overexpression led to opposite outcomes (Figs."
39343961
reach
"Functionally, elevated USP36 could promote proliferation, migration, and invasion of CRC cells in vitro and in vivo."
39343961
reach
"The transwell assay showed that the impaired migration and invasion capacity induced by USP36 depletion could be partially recovered by YAP overexpression in KYSE150 cells (Fig. S3I)."
36470870
reach
"USP36 promotes proliferation and invasion of esophageal squamous cell carcinoma by deubiquitination of YAP [104]."
36613989
USP36 affects NHP2
3 | 1 2
USP36 sumoylates NHP2.
| 1 2
USP36 sumoylates NHP2. 3 / 3
| 1 2
sparser
"Research indicates that USP36 augments the SUMOylation of small nucleolar ribonucleoprotein (snoRNP) components Nop58 and Nhp2, thereby enhancing their binding affinity to snoRNAs."
38785979
sparser
"We show that USP36 promotes the SUMOylation of the small nucleolar ribonucleoprotein (snoRNP) components Nop58 and Nhp2 in cells and in vitro and their binding to snoRNAs."
33852194
reach
"SENP3 is known to be the enzyme responsible for the deSUMOylation of NPM1 [71] and USP36 is known to be involved in the SUMOylation of many nucleolar proteins such as the small nucleolar ribonucleoprotein (snoRNP) components Nop58 and Nhp2 [28]."
38279024
USP36 binds NHP2.
3 |
USP36 binds NHP2. 3 / 3
3 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
33852194
biogrid
No evidence text available
33852194
USP36 affects Histone_H2B
| 1 5
sparser
"We show that USP36 interacts with H2B and deubiquitinates H2Bub1 in cells and in vitro ."
29274341
sparser
"USP36 interacts with H2B."
29274341
sparser
"Together, we conclude that USP36 interacts with H2B in cells and in vitro and that this likely occurs within the context of chromatin."
29274341
reach
"We show that USP36 interacts with H2B and deubiquitinates H2Bub1 in cells and invitro."
29274341
sparser
"USP36 interacts with H2B and deubiquitinates H2Bub1 in cells and in vitro ."
29274341
sparser
"The interaction of USP36 with H2B likely occurs within the context of chromatin as we found that a significant pool of USP36 is enriched on chromatin."
29274341
USP36 affects ESR1
1 | 5
ESR1 binds USP36. 6 / 6
1 | 5
sparser
"Further investigation confirmed that the interaction of USP36 and ERα promotes the deubiquitination of ERα."
39215346
sparser
"In our study, we found that USP36 interacts with ERα, leading to the suppression of ERα polyubiquitination and degradation in breast cancer cells, which indicated that USP36 linked to breast cancer proliferation and invasion via estrogen signaling."
39215346
biogrid
No evidence text available
31527615
sparser
"USP36 associates with ERα and modulates ERα stability in breast cancer cells."
39215346
sparser
"The immuno-precipitation assay in MCF-7 cells revealed that USP36 interacts with ERα (Fig. xref B-C)."
39215346
sparser
"Deletion constructs were created to study the interaction between USP36 and ERα."
39215346
SOD2 affects USP36
3 | 3
USP36 binds SOD2. 6 / 6
3 | 3
sparser
"As shown in xref b, USP36 associated with immunoprecipitated SOD2 at 2 h, but not at 4 h, indicating a transient interaction between the two molecules, in line with the transient increase in SOD2 levels."
34207085
sparser
"The study showed that anakinra promotes the binding of SOD2 to the deubiquitinase, ubiquitin specific peptidase 36 (USP36), and constitutive photomorphogenesis 9 (COP9) signalosome, thus increasing SOD2 protein longevity."
36845127
biogrid
No evidence text available
21268071
biogrid
No evidence text available
21268071
biogrid
No evidence text available
21268071
sparser
"Conversely, work in the mouse and human kidney suggests that Usp36 interacts with SOD2 in the mechanism of acute kidney injury due to ischaemia."
38734725
RBM28 affects USP36
1 | 5
USP36 binds RBM28. 6 / 6
1 | 5
reach
"More importantly, endogenous interactions between USP36 and RBM28 were validated in CRC cells (Fig. 2C)."
39343961
reach
"Then, truncated mutant fragments were generated to determine the specific regions responsible for USP36 and RBM28 interaction."
39343961
reach
"To verify the physical interaction between USP36 and RBM28, co-immunoprecipitation (Co-IP) were performed in HEK293T and CRC cells."
39343961
reach
"Mechanistically, USP36 could interact with and stabilize RBM28 via deubiquitination at K162 residue."
39343961
reach
"USP36 interacts with and upregulates RBM28 depending on its deubiquitinase activity."
39343961
biogrid
No evidence text available
36912080
Histone_H2B affects USP36
| 1 5
sparser
"We show that USP36 interacts with H2B and deubiquitinates H2Bub1 in cells and in vitro ."
29274341
sparser
"USP36 interacts with H2B."
29274341
sparser
"Together, we conclude that USP36 interacts with H2B in cells and in vitro and that this likely occurs within the context of chromatin."
29274341
reach
"We show that USP36 interacts with H2B and deubiquitinates H2Bub1 in cells and invitro."
29274341
sparser
"USP36 interacts with H2B and deubiquitinates H2Bub1 in cells and in vitro ."
29274341
sparser
"The interaction of USP36 with H2B likely occurs within the context of chromatin as we found that a significant pool of USP36 is enriched on chromatin."
29274341
FBXW7 affects USP36
2 | 2 1
FBXW7 binds USP36. 5 / 6
2 | 2 1
biogrid
No evidence text available
25775507
sparser
"Usp28 preferentially binds the Fbw7α isoform, whereas Usp36 selectively associates with Fbw7γ and both DUBs stabilize Myc."
26459133
reach
"USP28 and USP37 stabilize c-Myc in the nucleus [ 18 , 19 ], while USP36 interacts with Fbw7γ in the nucleolus and abolishes Fbw7γ- and Fbw7α-mediated c-Myc degradation [ 20 ]."
30343112
reach
"For example, USP28 and USP36 interact with FBW7 and reverse FBW7-mediated c-Myc degradation ( Popov et al., 2007 ; Sun et al., 2015 )."
34102342
biogrid
No evidence text available
25775507
ESR1 affects USP36
1 | 5
ESR1 binds USP36. 6 / 6
1 | 5
sparser
"Further investigation confirmed that the interaction of USP36 and ERα promotes the deubiquitination of ERα."
39215346
sparser
"In our study, we found that USP36 interacts with ERα, leading to the suppression of ERα polyubiquitination and degradation in breast cancer cells, which indicated that USP36 linked to breast cancer proliferation and invasion via estrogen signaling."
39215346
biogrid
No evidence text available
31527615
sparser
"USP36 associates with ERα and modulates ERα stability in breast cancer cells."
39215346
sparser
"The immuno-precipitation assay in MCF-7 cells revealed that USP36 interacts with ERα (Fig. xref B-C)."
39215346
sparser
"Deletion constructs were created to study the interaction between USP36 and ERα."
39215346
DOCK4 affects USP36
3 | 1 2
USP36 binds DOCK4. 6 / 6
3 | 1 2
biogrid
No evidence text available
33968925
reach
"To elucidate the interaction between DOCK4 and USP36, immunoprecipitation and Duolink proximity ligation assay were employed (Figures 4B,C)."
33968925
sparser
"First, we evidenced that USP36 physically interacts with DOCK4 by IP and in situ proximity ligation assay ( in situ PLA) ( xref )."
33968925
sparser
"To elucidate the interaction between DOCK4 and USP36, immunoprecipitation and Duolink proximity ligation assay were employed ( xref )."
33968925
biogrid
No evidence text available
33968925
biogrid
No evidence text available
33968925
USP36 affects PPME1
| 1 4
USP36 activates PPME1.
| 1 2
USP36 activates PPME1. 3 / 3
| 1 2
reach
"In summary, these findings indicate that USP36 functions as a deubiquitinase to modulate PME-1 and promote the ERK and AKT signaling pathways (Figure 2E)."
38785979
eidos
"Hence , we speculate that the up-regulation of PME-1 in HCC may be due to USP36 , which need further verified ."
32431540
reach
"USP36 increases PME-1 stability, and depletion of USP36 decreases the PME-1 expression level."
29577269
USP36 increases the amount of PPME1.
| 1
USP36 increases the amount of PPME1. 1 / 1
| 1
reach
"Previous studies demonstrated that USP36 can increase the expression of PME-1 by facilitating K48-linked polyubiquitination."
38785979
USP36 decreases the amount of PPME1.
| 1
USP36 decreases the amount of PPME1. 1 / 1
| 1
reach
"USP36 increases PME-1 stability, and depletion of USP36 decreases the PME-1 expression level."
29577269
USP36 affects DKC1
2 | 2 1
USP36 sumoylates DKC1.
| 2 1
USP36 sumoylates DKC1. 3 / 3
| 2 1
sparser
"Furthermore, USP36 also promotes the SUMOylation of snoRNP components Nop56 and DKC1."
38785979
reach
"They found that USP36 SUMOylates two proteins in each of these complexes: Nop58 and Nop56 in box C/D and Nhp2 and DKC1 in box H/ACA (Ryu et al., 2021)."
38455765
reach
"Furthermore, USP36 also promotes the SUMOylation of snoRNP components Nop56 and DKC1."
38785979
USP36 binds DKC1.
2 |
USP36 binds DKC1. 2 / 2
2 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
33852194
USP36 affects CHD7
| 3 2
USP36 binds CHD7.
| 1 2
USP36 binds CHD7. 3 / 3
| 1 2
sparser
"Co-immunoprecipitation (Co-IP) data suggest that endogenous USP36 interacts with CHD7 ( Figure 6 H)."
29533783
reach
"Consistent with Co-IP data, ectopically expressed and endogenous USP36 and CHD7 were localized to the nucleolus, which further underlines the USP36 and CHD7 interaction ( Figures 6 I and 6J)."
29533783
sparser
"Consistent with Co-IP data, ectopically expressed and endogenous USP36 and CHD7 were localized to the nucleolus, which further underlines the USP36 and CHD7 interaction ( Figures 6 I and 6J)."
29533783
USP36 activates CHD7.
| 2
USP36 activates CHD7. 2 / 2
| 2
reach
"Identifying disease-associated loci in combination with the expression studies of overlapping lncRNAs could provide powerful lncRNA-based prognostic markers.Downregulation of 6p22lncRNAs in NB cell li[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29533783
reach
"Supporting our notion, USP36 KD led to CHD7 destabilization and loss of SOX9 protein, while its overexpression stabilized CHD7, suggesting that USP36 post-translationally regulates CHD7 ( Figures 6 D [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29533783
Pirinixic acid affects USP36
4 |
Pirinixic acid decreases the amount of USP36.
2 |
Pirinixic acid decreases the amount of USP36. 2 / 2
2 |
ctd
No evidence text available
23811191
ctd
No evidence text available
21318169
Pirinixic acid increases the amount of USP36.
1 |
Pirinixic acid increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
19710929
Pirinixic acid activates USP36.
1 |
Pirinixic acid activates USP36. 1 / 1
1 |
ctd
No evidence text available
19710929
reach
"The loss of USP36 decreases the parkin-dependent mitophagy."
34023421
reach
"Furthermore, USP36 knockdown reduced the levels of Beclin-1 and ATG14 L. Therefore, knockdown of USP36 reportedly causes parkin-dependent mitophagy damage through the Beclin-1/ATG14 L pathway among th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34023421
USP36 activates autophagy of mitochondrion. 2 / 2
| 2
reach
"Thus, we hypothesize that the concerted reduction of Beclin-1 and ATG14L interferes with efficient mitophagy after USP36 knockdown.Together, we show that the loss of USP36 diminishes Parkin-dependent [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31550441
reach
"Thus, we hypothesize that nuclear USP36 function is necessary for Parkin-dependent mitophagy controlling the Beclin-1-ATG14L pathway.To identify new modulators of the Parkin-dependent mitophagy, we co[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31550441
USP36 affects amino acid
| 4
USP36 deubiquitinates amino acid. 4 / 4
| 4
reach
"Our mass spectrum analyses showed that lysine 146 (K146) and lysine 206 (K206) of Snail1 were two amino acid residues deubiquitinated by USP36 (Fig. 3g and Supplementary Fig. S2a)."
37833415
reach
"Taken together, these results indicate that USP36 is a bona fide nucleolar deubiquitinase of Snail1 and that K146/K206 are two key amino acid residues deubiquitinated by USP36."
37833415
reach
"Our abovementioned data indicated that K146/K206 on Snail1 are two key amino acid residues deubiquitinated by USP36."
37833415
reach
"We demonstrate that while Lys157 of Snail1 is critical for USP36-Snail1 protein complex formation, Lys146 and Lys206 on Snail1 are two key amino acid residues deubiquitinated by USP36."
37833415
USP36 affects UBE2I
3 | 1
UBE2I binds USP36. 4 / 4
3 | 1
reach
"USP36 interacts with SUMO2 and Ubc9 and directly mediates SUMOylation in cells and in vitro."
33852194
biogrid
No evidence text available
36912080
biogrid
No evidence text available
33852194
biogrid
No evidence text available
33852194
USP36 affects UBC
4 |
UBC binds USP36. 4 / 4
4 |
biogrid
No evidence text available
29576527
biogrid
No evidence text available
37443395
biogrid
No evidence text available
37443395
biogrid
No evidence text available
33141564
USP36 affects POLR1A
1 | 2 1
USP36 binds POLR1A.
1 | 1 1
USP36 binds POLR1A. 3 / 3
1 | 1 1
sparser
"We confirmed the interaction between USP36 and RPA194 in human cells using reciprocal immunoprecipitation (Fig.  xref and Supplementary Fig.  xref )."
39788980
biogrid
No evidence text available
36912080
reach
"We confirmed the interaction between USP36 and RPA194 in human cells using reciprocal immunoprecipitation (Fig. 5g and Supplementary Fig. 5e, f)."
39788980
USP36 ubiquitinates POLR1A.
| 1
USP36 leads to the ubiquitination of POLR1A. 1 / 1
| 1
reach
"Unexpectedly, USP36 depletion led to the formation of ‘nucleolar caps’ (Fig. 5h), highlighting the important role of proper deubiquitination of RPA194 in regulating of Pol I transcription."
39788980
USP36 affects NTRK1
3 | 1
USP36 binds NTRK1.
3 |
USP36 binds NTRK1. 3 / 3
3 |
biogrid
No evidence text available
27445338
biogrid
No evidence text available
27445338
biogrid
No evidence text available
27445338
USP36 increases the amount of NTRK1.
| 1
USP36 increases the amount of NTRK1. 1 / 1
| 1
reach
"Moreover, USP36 depletion leads to enhanced total and surface TrkA expression that results in increased NGF mediated TrkA activation and signaling that augments PC12 cell differentiation."
27445338
USP36 affects N
1 3 |
USP36 binds N. 2 / 2
1 1 |
biogrid
No evidence text available
| DOI
virhostnet
No evidence text available
34232536
USP36 binds N. 1 / 1
1 |
virhostnet
No evidence text available
34232536
USP36 binds N. 1 / 1
1 |
virhostnet
No evidence text available
34232536
USP36 affects FBL
4 |
FBL binds USP36. 4 / 4
4 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
34079125
biogrid
No evidence text available
33852194
biogrid
No evidence text available
29568061
USP36 affects FAU
4 |
USP36 binds FAU. 4 / 4
4 |
biogrid
No evidence text available
37443395
biogrid
No evidence text available
37443395
biogrid
No evidence text available
37443395
biogrid
No evidence text available
37443395
USP36 affects ERK
| 4
USP36 activates ERK. 4 / 4
| 4
reach
"Furthermore, we demonstrate that USP36 promotes the ERK and Akt signaling pathways."
29577269
reach
"USP36 modulates the activity of the Hippo/YAP, PRL1/Snail2, c-Myc/SOD2, CEP63/YAP1, Fbw7g/USP36/c-Myc, ERK/AKT ALR (augmentation of liver regeneration)/MDM2, and USP36/PARP1 pathways through interaction with specific components and exertion of deubiquitinating effects (Figure 2)."
38785979
reach
"The Ubiquitin Specific Peptidase USP36 has been shown to interact with FBW7 to regulate MYC stability and enhance ERK and AKT signaling pathways."
32220889
reach
"In summary, these findings indicate that USP36 functions as a deubiquitinase to modulate PME-1 and promote the ERK and AKT signaling pathways (Figure 2E)."
38785979
USP36 affects COPS3
| 1 3
COPS3 binds USP36. 4 / 4
| 1 3
sparser
"Anakinra Prevents SOD2 Degradation via USP36-COPS3."
34207085
sparser
"Mechanistically, anakinra appears to have prevented SOD2 degradation by interfering with the USP36-COPS3 complex rather than inducing its expression."
34207085
sparser
"The induction of SOD2 was selective, as other antioxidant enzymes did not appear to be modulated by anakinra, as occurs for other SOD2 mimetics, an effect that may be related to the ability of anakinra to interfere with the USP36-COPS3 complex, rather than engaging the Nrf2 pathway [ xref ]."
34207085
reach
"Specifically, from the results reported by He et al. [87], it appears that anakinra prevents SOD2 degradation by interfering with the USP36-COPS3 complex rather than by inducing its expression."
37507935
UBE2I affects USP36
3 | 1
UBE2I binds USP36. 4 / 4
3 | 1
reach
"USP36 interacts with SUMO2 and Ubc9 and directly mediates SUMOylation in cells and in vitro."
33852194
biogrid
No evidence text available
36912080
biogrid
No evidence text available
33852194
biogrid
No evidence text available
33852194
UBC affects USP36
4 |
UBC binds USP36. 4 / 4
4 |
biogrid
No evidence text available
29576527
biogrid
No evidence text available
37443395
biogrid
No evidence text available
37443395
biogrid
No evidence text available
33141564
N affects USP36
1 3 |
USP36 binds N. 2 / 2
1 1 |
biogrid
No evidence text available
| DOI
virhostnet
No evidence text available
34232536
USP36 binds N. 1 / 1
1 |
virhostnet
No evidence text available
34232536
USP36 binds N. 1 / 1
1 |
virhostnet
No evidence text available
34232536
JNK affects USP36
| 4
JNK increases the amount of USP36. 4 / 4
| 4
reach
"Importantly, while a selective p38 inhibitor, SB203580, failed to block the HHT-induced upregulation of USP36 and Snail1, inhibition of JNK by SP600125 completely inhibited HHT-induced upregulation of the mRNA and protein expression of USP36 (Supplementary Fig. S5b–d)."
37833415
reach
"As shown in Fig. 7a, b and Supplementary Fig. S8a, b, again, HHT effectively activated JNK, leading to upregulated expression of nucleolar USP36 and Snail1, accompanied by little apoptosis in triple-negative breast cancer SUM159, HCC1806, or Hs 578T cells."
37833415
reach
"In keeping with our finding that JNK signaling upregulates USP36 expression, a combination of HHT with SP600125, a selective inhibitor of JNK, synergistically induced apoptosis, which could be largely rescued by ectopic expression of USP36 (Fig. 6q and Supplementary Fig. S7h)."
37833415
reach
"By contrast, rapamycin, an mTOR inhibitor to inhibit protein synthesis, failed to either activate JNK or to upregulate USP36 and Snail1 protein expression (Fig. 2c, d), in keeping with our previous observation that rapamycin failed to promote Snail1 nucleolar accumulation (Fig. 1b, c)."
37833415
FBL affects USP36
4 |
FBL binds USP36. 4 / 4
4 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
34079125
biogrid
No evidence text available
33852194
biogrid
No evidence text available
29568061
FAU affects USP36
4 |
USP36 binds FAU. 4 / 4
4 |
biogrid
No evidence text available
37443395
biogrid
No evidence text available
37443395
biogrid
No evidence text available
37443395
biogrid
No evidence text available
37443395
COPS3 affects USP36
| 1 3
COPS3 binds USP36. 4 / 4
| 1 3
sparser
"Anakinra Prevents SOD2 Degradation via USP36-COPS3."
34207085
sparser
"Mechanistically, anakinra appears to have prevented SOD2 degradation by interfering with the USP36-COPS3 complex rather than inducing its expression."
34207085
sparser
"The induction of SOD2 was selective, as other antioxidant enzymes did not appear to be modulated by anakinra, as occurs for other SOD2 mimetics, an effect that may be related to the ability of anakinra to interfere with the USP36-COPS3 complex, rather than engaging the Nrf2 pathway [ xref ]."
34207085
reach
"Specifically, from the results reported by He et al. [87], it appears that anakinra prevents SOD2 degradation by interfering with the USP36-COPS3 complex rather than by inducing its expression."
37507935
CHD7 affects USP36
| 2 2
CHD7 binds USP36.
| 1 2
USP36 binds CHD7. 3 / 3
| 1 2
sparser
"Co-immunoprecipitation (Co-IP) data suggest that endogenous USP36 interacts with CHD7 ( Figure 6 H)."
29533783
reach
"Consistent with Co-IP data, ectopically expressed and endogenous USP36 and CHD7 were localized to the nucleolus, which further underlines the USP36 and CHD7 interaction ( Figures 6 I and 6J)."
29533783
sparser
"Consistent with Co-IP data, ectopically expressed and endogenous USP36 and CHD7 were localized to the nucleolus, which further underlines the USP36 and CHD7 interaction ( Figures 6 I and 6J)."
29533783
CHD7 activates USP36.
| 1
CHD7 activates USP36. 1 / 1
| 1
reach
"Another long noncoding RNA, 6p22lncRNA, was demonstrated to regulate the stability of CHD7, which modulates the USP36 localization that is responsible for Sox9 expression."
38254827
ACVRL1 affects USP36
| 4
ACVRL1 increases the amount of USP36. 4 / 4
| 4
reach
"Indeed, HHT and several ribotoxic stress inducers, including anisomycin, puromycin, and blasticidin, activated JNK signaling in the upregulation of USP36 and Snail1 protein expression (Fig. 2c, d)."
37833415
reach
"Importantly, while a selective p38 inhibitor, SB203580, failed to block the HHT-induced upregulation of USP36 and Snail1, inhibition of JNK by SP600125 completely inhibited HHT-induced upregulation of the mRNA and protein expression of USP36 (Supplementary Fig. S5b–d)."
37833415
reach
"Importantly, KRIBB11 also markedly inhibited HHT-mediated upregulation of USP36 and Snail1 expression (Supplementary Fig. S6h)."
37833415
reach
"In keeping with our finding that JNK signaling upregulates USP36 expression, a combination of HHT with SP600125, a selective inhibitor of JNK, synergistically induced apoptosis, which could be largely rescued by ectopic expression of USP36 (Fig. 6q and Supplementary Fig. S7h)."
37833415
17beta-estradiol affects USP36
4 |
17beta-estradiol increases the amount of USP36.
3 |
17beta-estradiol increases the amount of USP36. 3 / 3
3 |
ctd
No evidence text available
32145629
ctd
No evidence text available
31614463
ctd
No evidence text available
23019147
17beta-estradiol decreases the amount of USP36.
1 |
17beta-estradiol decreases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
32145629
Cisplatin affects USP36
3 |
Cisplatin decreases the amount of USP36.
2 |
Cisplatin decreases the amount of USP36. 2 / 2
2 |
ctd
No evidence text available
27594783
ctd
No evidence text available
27392435
Cisplatin increases the amount of USP36.
1 |
Cisplatin increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
20849824
Bisphenol A affects USP36
3 |
Bisphenol A increases the amount of USP36. 3 / 3
3 |
ctd
No evidence text available
25181051
ctd
No evidence text available
26063408
ctd
No evidence text available
32145629
USP36 affects rRNA processing
| 1 2
USP36 activates rRNA processing. 2 / 2
| 1 1
eidos
"Functionally , we show that knockdown of USP36 markedly impairs rRNA processing and translation ."
33852194
reach
"The deubiquitinase USP36 promotes SUMOylation of NOP56 and NOP58 and promotes binding of NOP58 to snoRNA, and knockout of deubiquitinase USP36 significantly inhibits rRNA processing (20)."
36741964
USP36 activates rRNA processing. 1 / 1
| 1
reach
"Functionally, we show that knockdown of USP36 markedly impairs rRNA processing and translation."
33852194
USP36 activates epithelial to mesenchymal transition. 3 / 3
| 3
reach
"Additionally, USP36 directly bound to and mediated the de-ubiquitination of DOCK4, whereas DOCK4 knockdown effectively abolished EMT induced by USP36 overexpression through suppressing Wnt/β-catenin signaling in TECs (Zhu et al., 2021)."
35082683
reach
"The results revealed that DOCK4 knockdown effectively abolished USP36 overexpression-induced EMT through suppressing Wnt/β-catenin signaling pathway in TECs (Figures 5M,N)."
33968925
reach
"Zhu et al. reported that the expression of ubiquitin specific proteases 36 (USP36), a member of deubiquitinating enzymes family, was induced in DKD in human and murine model and in HG-treated TECs, and the overexpression of USP36 enhanced EMT in TECs."
35082683
USP36 affects cell growth
| 3
USP36 activates cell growth. 3 / 3
| 3
reach
"In CCK8 and colony formation assays, elevated RBM28 enhanced cell proliferation and reversed the cell growth decreased by USP36 knockdown."
39343961
reach
"Through CCK8 and colony formation assays, we found that Idasanutlin (a p53 activator) markedly suppressed cell proliferation and counteracted the increased cell growth driven by the overexpression of USP36 and RBM28 in LoVo cells (Fig. S7A, B)."
39343961
reach
"Conversely, RBM28 depletion attenuated cell proliferation and restored the enhanced cell growth caused by USP36 overexpression (Fig. S5A–D)."
39343961
USP36 affects STAU1
3 |
STAU1 binds USP36. 3 / 3
3 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
30948266
biogrid
No evidence text available
36232890
USP36 affects SOX9
| 3
SOX9 binds USP36. 3 / 3
| 3
sparser
"Later, results from a collaborative study showed that a pair of sense/antisense lncRNA encoded by CASC15 and NBAT1 promote differentiation through their regulatory interactions with key cancer-associated genes SOX9 and USP36."
36923440
sparser
"CASC15 and NBAT1 , which map to NB hotspot 6p22.3, promote differentiation through their regulatory interactions with key cancer-associated genes SOX9 and USP36 , located on chromosome 17q, a region o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29533783
sparser
"Recent data shows that CASC15 and NBAT1 promote differentiation by interactions with SOX9 and USP36 , located on chromosome 17q that is frequently gained in high-risk neuroblastomas."
30760980
USP36 affects RPS6
3 |
RPS6 binds USP36. 3 / 3
3 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
29568061
biogrid
No evidence text available
34079125
USP36 affects RIPK1
| 2 1
USP36 leads to the ubiquitination of RIPK1. 3 / 3
| 2 1
sparser
"As shown in xref F , RIPK1 ubiquitination was enhanced by cIAP1 (lane 3) and USP36 (lane 4)."
38876304
reach
"USP36 stabilizes cIAP1 expression, which led us to test the possibility that USP36 also modulates RIPK1 ubiquitination."
38876304
reach
"As shown in Fig. 8F, RIPK1 ubiquitination was enhanced by cIAP1 (lane 3) and USP36 (lane 4)."
38876304
USP36 affects NT5E
3 |
NT5E binds USP36. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
USP36 affects KIAA0232
3 |
USP36 binds KIAA0232. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
USP36 affects IMD
| 3
USP36 inhibits IMD. 3 / 3
| 3
reach
"Another recent study demonstrated that the deubiquitinating enzyme Usp36, which had been shown to negatively regulate the IMD pathway in flies, also negatively regulates p62 dependent selective autophagy in flies and human cells [XREF_BIBR]."
23689401
reach
"The D. melanogaster ubiquitin-specific protease 36 (USP36) and USP2 negatively regulate the IMD pathway after infection by Gram-negative pathogens (42, 43)."
36537797
reach
"USP36 removes K63-polyubiquitin chains from IMD and then appears to increase the addition of K48-ubiquitin chains and degradation of IMD."
20852987
USP36 affects H2BC3
3 |
USP36 binds H2BC3. 3 / 3
3 |
biogrid
No evidence text available
29274341
biogrid
No evidence text available
29274341
biogrid
No evidence text available
29274341
USP36 affects GNL2
3 |
USP36 binds GNL2. 3 / 3
3 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
19615732
biogrid
No evidence text available
36912080
USP36 affects GEF
| 3
USP36 deubiquitinates GEF. 3 / 3
| 3
reach
"Further investigation into the mechanisms proved that USP36 could directly bind to and mediate the deubiquitination of dedicator of cytokinesis 4 (DOCK4), a guanine nucleotide exchange factor (GEF) that could activate Wnt/beta-catenin signaling pathway and induce EMT."
33968925
reach
"USP36 contributes to DN progression by directly deubiquitinating cytokinin 4 (DOCK4) and aggravating guanine nucleotide exchange factor (GEF)-mediated EMT (136) ( Table 9 ).2.8.5 Roles of USPs in diabetic neuropathic pain."
38322269
reach
"Further, we found that USP36 could directly bind to and mediate the deubiquitination of dedicator of cytokinesis 4 (DOCK4), a guanine nucleotide exchange factor (GEF) that could activate Wnt/β-catenin signaling pathway and induce EMT."
33968925
USP36 affects EZH2
1 2 |
USP36 binds EZH2.
2 |
USP36 binds EZH2. 2 / 2
2 |
biogrid
No evidence text available
31434700
biogrid
No evidence text available
31434700
USP36 increases the amount of EZH2.
1 |
USP36 increases the amount of EZH2. 1 / 1
1 |
signor
"We observed a MELK-mediated increase of EZH2 S220 phosphorylation along with a concomitant loss of EZH2 K222 ubiquitination, suggesting a phosphorylation-dependent regulation of EZH2 ubiquitination.  Furthermore, we identify USP36 as the deubiquitinating enzyme that deubiquitinates EZH2 at K222."
31434700
reach
"Considering the stabilizing effect of USP36 on RBM28, we hypothesized whether USP36 inactivates p53 signaling pathway via RBM28."
39343961
reach
"Collectively, these results indicated that USP36 inhibits p53 transcriptional activity and negatively regulates p53 signaling pathway."
39343961
reach
"USP36 inhibits p53 signaling pathway by impairing p53 transcriptional activity."
39343961
USP36 affects CHD4
3 |
USP36 binds CHD4. 3 / 3
3 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
28977666
biogrid
No evidence text available
19615732
USP36 affects CEP63
2 | 1
USP36 binds CEP63.
2 |
CEP63 binds USP36. 2 / 2
2 |
biogrid
No evidence text available
35989368
biogrid
No evidence text available
35989368
USP36 activates CEP63.
| 1
USP36 activates CEP63. 1 / 1
| 1
reach
"USP36 modulates the activity of the Hippo/YAP, PRL1/Snail2, c-Myc/SOD2, CEP63/YAP1, Fbw7g/USP36/c-Myc, ERK/AKT ALR (augmentation of liver regeneration)/MDM2, and USP36/PARP1 pathways through interaction with specific components and exertion of deubiquitinating effects (Figure 2)."
38785979
USP36 affects CELSR2
3 |
USP36 binds CELSR2. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
USP36 affects BECN1
| 3
USP36 increases the amount of BECN1.
| 2
USP36 increases the amount of BECN1. 2 / 2
| 2
reach
"Furthermore, USP36 knockdown reduced the levels of Beclin-1 and ATG14 L. Therefore, knockdown of USP36 reportedly causes parkin-dependent mitophagy damage through the Beclin-1/ATG14 L pathway among th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34023421
reach
"This likely indicates loss of USP36 indirectly modulates H2B ubiquitination via upregulation of other DUBs, like USP43, resulting in differential expression of subsets of genes.Our data showed a reduc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31550441
USP36 phosphorylates BECN1.
| 1
USP36 leads to the phosphorylation of BECN1 on S93. 1 / 1
| 1
reach
"However, only USP36 WT but not S29A rescued the Beclin-1 phosphorylation at Ser93 ( Fig. 7 E)."
31550441
USP36 affects AKT
| 3
USP36 activates AKT. 3 / 3
| 3
reach
"The Ubiquitin Specific Peptidase USP36 has been shown to interact with FBW7 to regulate MYC stability and enhance ERK and AKT signaling pathways."
32220889
reach
"Furthermore, we demonstrate that USP36 promotes the ERK and Akt signaling pathways."
29577269
reach
"USP36 modulates the activity of the Hippo/YAP, PRL1/Snail2, c-Myc/SOD2, CEP63/YAP1, Fbw7g/USP36/c-Myc, ERK/AKT ALR (augmentation of liver regeneration)/MDM2, and USP36/PARP1 pathways through interaction with specific components and exertion of deubiquitinating effects (Figure 2)."
38785979
STAU1 affects USP36
3 |
STAU1 binds USP36. 3 / 3
3 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
30948266
biogrid
No evidence text available
36232890
SOX9 affects USP36
| 3
SOX9 binds USP36. 3 / 3
| 3
sparser
"Later, results from a collaborative study showed that a pair of sense/antisense lncRNA encoded by CASC15 and NBAT1 promote differentiation through their regulatory interactions with key cancer-associated genes SOX9 and USP36."
36923440
sparser
"CASC15 and NBAT1 , which map to NB hotspot 6p22.3, promote differentiation through their regulatory interactions with key cancer-associated genes SOX9 and USP36 , located on chromosome 17q, a region o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29533783
sparser
"Recent data shows that CASC15 and NBAT1 promote differentiation by interactions with SOX9 and USP36 , located on chromosome 17q that is frequently gained in high-risk neuroblastomas."
30760980
RPS6 affects USP36
3 |
RPS6 binds USP36. 3 / 3
3 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
29568061
biogrid
No evidence text available
34079125
POLR1A affects USP36
1 | 1 1
USP36 binds POLR1A. 3 / 3
1 | 1 1
sparser
"We confirmed the interaction between USP36 and RPA194 in human cells using reciprocal immunoprecipitation (Fig.  xref and Supplementary Fig.  xref )."
39788980
biogrid
No evidence text available
36912080
reach
"We confirmed the interaction between USP36 and RPA194 in human cells using reciprocal immunoprecipitation (Fig. 5g and Supplementary Fig. 5e, f)."
39788980
NTRK1 affects USP36
3 |
USP36 binds NTRK1. 3 / 3
3 |
biogrid
No evidence text available
27445338
biogrid
No evidence text available
27445338
biogrid
No evidence text available
27445338
NT5E affects USP36
3 |
NT5E binds USP36. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
33961781
biogrid
No evidence text available
28514442
NOP58 affects USP36
3 |
USP36 binds NOP58. 3 / 3
3 |
biogrid
No evidence text available
33852194
biogrid
No evidence text available
33852194
biogrid
No evidence text available
36912080
NOP56 affects USP36
3 |
NOP56 binds USP36. 3 / 3
3 |
biogrid
No evidence text available
33852194
biogrid
No evidence text available
34079125
biogrid
No evidence text available
36912080
NHP2 affects USP36
3 |
USP36 binds NHP2. 3 / 3
3 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
33852194
biogrid
No evidence text available
33852194
LAS1L affects USP36
1 | 2
USP36 binds LAS1L. 3 / 3
1 | 2
sparser
"We also confirmed that endogenous USP36 interacts with endogenous Las1L ( xref )."
39356143
biogrid
No evidence text available
36912080
sparser
"We showed that USP36 interacts with the rixosome components and that abrogating Las1L SUMOylation by the K565R mutation attenuated Las1L’s interaction with the pre-60S ribosome, suggesting that USP36 may regulate Las1L SUMOylation and 60S ribosome biogenesis in the context of the rixosome."
39356143
KIAA0232 affects USP36
3 |
USP36 binds KIAA0232. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
H2BC3 affects USP36
3 |
USP36 binds H2BC3. 3 / 3
3 |
biogrid
No evidence text available
29274341
biogrid
No evidence text available
29274341
biogrid
No evidence text available
29274341
GNL2 affects USP36
3 |
USP36 binds GNL2. 3 / 3
3 |
biogrid
No evidence text available
33961781
biogrid
No evidence text available
19615732
biogrid
No evidence text available
36912080
CHD4 affects USP36
3 |
USP36 binds CHD4. 3 / 3
3 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
28977666
biogrid
No evidence text available
19615732
CELSR2 affects USP36
3 |
USP36 binds CELSR2. 3 / 3
3 |
biogrid
No evidence text available
26186194
biogrid
No evidence text available
28514442
biogrid
No evidence text available
33961781
BIRC5 affects USP36
| 1 2
BIRC5 binds USP36. 3 / 3
| 1 2
sparser
"Therefore, a peptide including the C131 residue of the USP36 sequence might block the interaction between survivin and USP36."
38876304
sparser
"Structural determinants of USP36–cIAP1 and USP36–survivin interactions."
38876304
reach
"Therefore, a peptide including the C131 residue of the USP36 sequence might block the interaction between survivin and USP36."
38876304
Air Pollutants affects USP36
3 |
Air Pollutants increases the amount of USP36. 3 / 3
3 |
ctd
No evidence text available
38245732
ctd
No evidence text available
32579111
ctd
No evidence text available
38156290
Titanium dioxide affects USP36
2 |
Titanium dioxide increases the amount of USP36. 2 / 2
2 |
ctd
No evidence text available
31298478
ctd
No evidence text available
29264374
Perfluorooctanesulfonamide increases the amount of USP36. 2 / 2
2 |
ctd
No evidence text available
39104825
ctd
No evidence text available
31706782
Nucleolar Fbw7gamma affects USP36
| 2
USP36 binds nucleolar Fbw7gamma. 2 / 2
| 2
reach
"Interestingly, USP36 interacts with the nucleolar Fbw7gamma but not the nucleoplasmic Fbw7alpha."
25775507
reach
"USP36, a highly expressed USP in a subset of human breast and lung cancers, could interact with the nucleolar Fbw7gamma and maintain c-Myc stability in the nucleolus."
33643919
HnRNPH1/H2 affects USP36
| 2
HnRNPH1/H2 inhibits USP36. 2 / 2
| 2
reach
"Upregulation of c-MYC reversed the downregulation of hnRNPH1/H2 induced inhibition of USP36."
35133629
reach
"Overexpression of hnRNPH1/H2 reversed the downregulation of KHK-A induced inhibition of USP36."
35133629
Cyclosporin A affects USP36
2 |
Cyclosporin A increases the amount of USP36. 2 / 2
2 |
ctd
No evidence text available
25562108
ctd
No evidence text available
20106945
WDR36 affects USP36
2 |
USP36 binds WDR36. 2 / 2
2 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
19615732
WDR3 affects USP36
2 |
USP36 binds WDR3. 2 / 2
2 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
19615732
UTP4 affects USP36
2 |
UTP4 binds USP36. 2 / 2
2 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
34079125
UTP18 affects USP36
2 |
USP36 binds UTP18. 2 / 2
2 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
19615732
UTP14A affects USP36
2 |
UTP14A binds USP36. 2 / 2
2 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
30343112
USP36 affects translation
| 1 1
USP36 activates translation. 2 / 2
| 1 1
reach
"Functionally, we show that knockdown of USP36 markedly impairs rRNA processing and translation."
33852194
eidos
"Functionally , we show that knockdown of USP36 markedly impairs rRNA processing and translation ."
33852194
sparser
"The deubiquitinase USP36 promotes snoRNP group SUMOylation and is essential for ribosome biogenesis."
33852194
sparser
"Thus, USP36 promotes snoRNP group SUMOylation and is critical for ribosome biogenesis and protein translation."
33852194
USP36 affects nucleolar Fbw7gamma
| 2
USP36 binds nucleolar Fbw7gamma. 2 / 2
| 2
reach
"Interestingly, USP36 interacts with the nucleolar Fbw7gamma but not the nucleoplasmic Fbw7alpha."
25775507
reach
"USP36, a highly expressed USP in a subset of human breast and lung cancers, could interact with the nucleolar Fbw7gamma and maintain c-Myc stability in the nucleolus."
33643919
USP36 activates myasthenia gravis anti-skeletal muscle antibody. 2 / 2
| 2
eidos
"As shown in Figures 3D , E , E-cadherin was significantly enhanced and alpha-SMA was obviously decreased by knockdown of USP36 in TECs ."
33968925
eidos
"As shown in Figures 3F , G , E-cadherin was obviously decreased and alpha-SMA was significantly enhanced in TECs under high glucose , while knockdown of USP36 could effectively reverse the expression of E-cadherin and alpha-SMA , which suggesting that up-regulation of USP36 may be an upstream mechanism for EMT and diabetic tubulointerstitial fibrosis ."
33968925
USP36 affects gene expression
| 2
USP36 activates gene expression. 2 / 2
| 2
reach
"The qPCR data showed that YAP overexpression could rescue Hippo target gene expression, which was reduced by USP36 silencing (Fig. S3D–F)."
36470870
reach
"This likely indicates loss of USP36 indirectly modulates H2B ubiquitination via upregulation of other DUBs, like USP43, resulting in differential expression of subsets of genes.Our data showed a reduc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31550441
USP36 affects cell migration
| 2
reach
"The Trans-well assay showed that USP36 knockdown inhibited cell migration capacity in ECA109, KYSE150, and EC9706 cells (Figs."
36470870
reach
"In the wound healing assay, YAP overexpression also restored the cell migration rate, which was reduced by USP36 depletion in KYSE150 cells (Fig. S3L)."
36470870
reach
"Our study also uncovers a role of USP36 in the 6p22lncRNA-mediated differentiation, thus opening alternate therapeutic opportunities for HR NBs."
29533783
reach
"USP36 KD promoted neuronal differentiation, whereas its overexpression perturbs neuronal differentiation ( Figure S6 F)."
29533783
USP36 affects cell death
| 2
USP36 inhibits cell death. 2 / 2
| 2
reach
"The apoptosis assay demonstrated that USP36 overexpression could prevent cell death in ECA109 cells (Fig. 4F), which was also observed in the western blot, caspase3(cleaved) protein levels was noticeably decreased by USP36 silencing (Fig. S3A)."
36470870
reach
"Moreover, the expression of USP36 suppressed cell death induced by Fas (Fig. 8C, lanes 5 and 6)."
38876304
USP36 affects Wnt/β-catenin
| 2
USP36 inhibits Wnt/β-catenin. 2 / 2
| 2
reach
"The results revealed that DOCK4 knockdown effectively abolished USP36 overexpression-induced EMT through suppressing Wnt/β-catenin signaling pathway in TECs (Figures 5M,N)."
33968925
reach
"Additionally, USP36 directly bound to and mediated the de-ubiquitination of DOCK4, whereas DOCK4 knockdown effectively abolished EMT induced by USP36 overexpression through suppressing Wnt/β-catenin signaling in TECs (Zhu et al., 2021)."
35082683
USP36 affects WDR36
2 |
USP36 binds WDR36. 2 / 2
2 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
19615732
USP36 affects WDR3
2 |
USP36 binds WDR3. 2 / 2
2 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
19615732
USP36 affects UTP4
2 |
UTP4 binds USP36. 2 / 2
2 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
34079125
USP36 affects UTP18
2 |
USP36 binds UTP18. 2 / 2
2 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
19615732
USP36 affects UTP14A
2 |
UTP14A binds USP36. 2 / 2
2 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
30343112
USP36 affects TRIM26
2 |
USP36 binds TRIM26. 2 / 2
2 |
biogrid
No evidence text available
23105109
biogrid
No evidence text available
36912080
USP36 affects TEAD
| 2
USP36 activates TEAD. 2 / 2
| 2
reach
"The luciferase reporter assay demonstrated that USP36 inhibition suppressed TEAD response element activity in ECA109, KYSE150 and EC9706 cells (Fig. 2D)."
36470870
reach
"The luciferase reporter assay showed that USP36 overexpression enhanced TEAD response element activity in ECA109 cells (Fig. 2H)."
36470870
USP36 affects TBL3
2 |
USP36 binds TBL3. 2 / 2
2 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
19615732
USP36 affects TAFAZZIN
2 |
USP36 binds TAFAZZIN. 2 / 2
2 |
biogrid
No evidence text available
35820928
biogrid
No evidence text available
35820928
USP36 affects SRPK2
2 |
SRPK2 binds USP36. 2 / 2
2 |
biogrid
No evidence text available
26167880
biogrid
No evidence text available
36912080
USP36 affects SNU13
2 |
USP36 binds SNU13. 2 / 2
2 |
biogrid
No evidence text available
33852194
biogrid
No evidence text available
36912080
USP36 affects SNAI2
| 2
USP36 binds SNAI2. 2 / 2
| 2
sparser
"To determine whether USP36 directly interacts with Snail2, HEK293T cells were co-transfected with Flag-tagged USP36-WT or USP36-C131A along with His-tagged Snail2."
35111679
sparser
"Co-immunoprecipitation (Co-IP) confirmed that both wild type and mutant USP36 bound to Snail2 ( xref ), indicating that the DUB activity of USP36 was independent of its interaction with Snail2."
35111679
USP36 affects RPL31
2 |
RPL31 binds USP36. 2 / 2
2 |
biogrid
No evidence text available
34079125
biogrid
No evidence text available
36912080
USP36 affects RPL30
2 |
USP36 binds RPL30. 2 / 2
2 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
36912080
USP36 affects RPL10
2 |
RPL10 binds USP36. 2 / 2
2 |
biogrid
No evidence text available
26496610
biogrid
No evidence text available
36912080
USP36 affects RAP80-BRCA1
| 1 1
USP36 inhibits RAP80-BRCA1. 2 / 2
| 1 1
reach
"USP37 and USP36 prevent excessive spreading of RAP80-BRCA1 from DSBs."
| PMC
eidos
"USP37 and USP36 prevent excessive spreading of RAP80-BRCA1 from DSBs ."
| PMC
USP36 affects PWP2
2 |
USP36 binds PWP2. 2 / 2
2 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
19615732
USP36 affects PTBP1
2 |
PTBP1 binds USP36. 2 / 2
2 |
biogrid
No evidence text available
35964538
biogrid
No evidence text available
35964538
USP36 affects PRKN
| 2
USP36 activates PRKN. 2 / 2
| 2
reach
"Thus, we hypothesize that the concerted reduction of Beclin-1 and ATG14L interferes with efficient mitophagy after USP36 knockdown.Together, we show that the loss of USP36 diminishes Parkin-dependent [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31550441
reach
"In that study, it has been found that USP36 mediated parkin dependent mitophagy is beclin 1 and Atg14L dependent and it involves Ser93 phosphorylation of beclin 1."
32428566
USP36 affects POLR1G
2 |
POLR1G binds USP36. 2 / 2
2 |
biogrid
No evidence text available
34079125
biogrid
No evidence text available
36912080
USP36 affects POLR1E
2 |
POLR1E binds USP36. 2 / 2
2 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
34079125
USP36 affects NUDCD1
2 |
USP36 binds NUDCD1. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
36912080
USP36 affects NPM3
2 |
NPM3 binds USP36. 2 / 2
2 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
33961781
USP36 affects NOP10
2 |
USP36 binds NOP10. 2 / 2
2 |
biogrid
No evidence text available
33852194
biogrid
No evidence text available
36912080
USP36 affects NLE1
2 |
NLE1 binds USP36. 2 / 2
2 |
biogrid
No evidence text available
37689310
biogrid
No evidence text available
36912080
USP36 affects NIFK
2 |
NIFK binds USP36. 2 / 2
2 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
34079125
USP36 affects NEDD4L
| 1
USP36 binds NEDD4L. 1 / 2
| 1
reach
"Instead, USP36 binds to Nedd4-2 and regulates the association of TrkA and Nedd4-2."
27445338
USP36 affects MKI67
2 |
MKI67 binds USP36. 2 / 2
2 |
biogrid
No evidence text available
26949251
biogrid
No evidence text available
36912080
USP36 affects Ischemia
| 2
USP36 inhibits Ischemia.
| 1
USP36 inhibits Ischemia. 1 / 1
| 1
reach
"In summary, our findings indicate that USP36 reduce ischemia induced renal proximal tubular cells apoptosis and most likely through the c-Myc and SOD2 signaling pathway.The mouse AKI model was induced[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30975468
USP36 activates Ischemia.
| 1
USP36 activates Ischemia. 1 / 1
| 1
reach
"The overexpression of USP36 increased c-Myc protein level in ischemia treated HK-2 cells, without affecting its mRNA level."
30975468
USP36 affects H4C16
2 |
H4C16 binds USP36. 2 / 2
2 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
30804502
USP36 affects H2Bub1
| 2
USP36 decreases the amount of H2Bub1.
| 1
Modified USP36 decreases the amount of H2Bub1. 1 / 1
| 1
reach
"Overexpression of USP36 markedly reduced the levels of H2Bub1 in cells."
29274341
USP36 activates H2Bub1.
| 1
USP36 activates H2Bub1. 1 / 1
| 1
reach
"Using the p21 gene as a model, we demonstrate that depletion of USP36 increases H2Bub1 at the p21 locus, primarily within its gene body."
29274341
USP36 affects EXOSC4
2 |
USP36 binds EXOSC4. 2 / 2
2 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
36912080
USP36 affects EXOSC3
2 |
USP36 binds EXOSC3. 2 / 2
2 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
36912080
USP36 affects EIF6
2 |
EIF6 binds USP36. 2 / 2
2 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
34079125
USP36 affects DDX41
2 |
USP36 binds DDX41. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
36912080
USP36 affects Cardiotoxicity
| 2
reach
"Additionally, PARP1 mediates the effect of USP36 on Dox-induced cardiotoxicity modulation."
38785979
reach
"These data showed that USP36 promotes Dox-induced cardiomyocyte oxidative stress injury and apoptosis via PARP1.To better understand the role and functional significance of USP36 in Dox-induced cardio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38307305
USP36 affects Carcinogenesis
| 1 1
USP36 activates Carcinogenesis. 2 / 2
| 1 1
reach
"Conversely, silencing USP36 inhibited tumorigenesis."
39215346
eidos
"207 In addition to Fbw7 , other E3 ligases , such as beta-TrCP1 , CHIP and FBXO32 , can also ubiquitinate c-Myc , mediate its subsequent degradation and inhibit tumorigenesis.208-210 Moreover , the USP37 and USP36 can promote tumorigenesis by stabilizing c-Myc.211 ,212 By mass spectrometry , SUMO ligase protein inhibitor of activated STAT ( PIAS ) and Sentrin-specific protease 7 ( SENP7 ) were also found to control the SUMOylation of c-Myc at K326 and regulate its ubiquitination and degradation ( Fig. 2c ) .213 Ubiquitination regulates p53 p53 , one of the most important tumor suppressors , works in multiple cellular processes , such as cell cycle regulation , DNA repair and apoptosis ."
32140262
USP36 affects BIRC3
| 2
USP36 increases the amount of BIRC3. 2 / 2
| 2
reach
"Despite its shared high sequence similarity with cIAP1, the expression of cIAP2 was not impaired by USP36 knockdown in our study (Fig. 3D), which might be attributed to their different subcellular distribution."
38876304
reach
"In addition, cIAP2 was expressed in slightly higher amounts when cIAP1 was reduced by USP36 knockdown."
38876304
USP36 affects ATG14
| 2
USP36 increases the amount of ATG14. 2 / 2
| 2
reach
"This likely indicates loss of USP36 indirectly modulates H2B ubiquitination via upregulation of other DUBs, like USP43, resulting in differential expression of subsets of genes.Our data showed a reduc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31550441
reach
"Furthermore, USP36 knockdown reduced the levels of Beclin-1 and ATG14 L. Therefore, knockdown of USP36 reportedly causes parkin-dependent mitophagy damage through the Beclin-1/ATG14 L pathway among th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34023421
USP36 affects 9c
2 |
9c binds USP36. 2 / 2
2 |
biogrid
No evidence text available
| DOI
biogrid
No evidence text available
| DOI
TRIM26 affects USP36
2 |
USP36 binds TRIM26. 2 / 2
2 |
biogrid
No evidence text available
23105109
biogrid
No evidence text available
36912080
TBL3 affects USP36
2 |
USP36 binds TBL3. 2 / 2
2 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
19615732
TAFAZZIN affects USP36
2 |
USP36 binds TAFAZZIN. 2 / 2
2 |
biogrid
No evidence text available
35820928
biogrid
No evidence text available
35820928
SRPK2 affects USP36
2 |
SRPK2 binds USP36. 2 / 2
2 |
biogrid
No evidence text available
26167880
biogrid
No evidence text available
36912080
SNU13 affects USP36
2 |
USP36 binds SNU13. 2 / 2
2 |
biogrid
No evidence text available
33852194
biogrid
No evidence text available
36912080
SNAI2 affects USP36
| 2
USP36 binds SNAI2. 2 / 2
| 2
sparser
"To determine whether USP36 directly interacts with Snail2, HEK293T cells were co-transfected with Flag-tagged USP36-WT or USP36-C131A along with His-tagged Snail2."
35111679
sparser
"Co-immunoprecipitation (Co-IP) confirmed that both wild type and mutant USP36 bound to Snail2 ( xref ), indicating that the DUB activity of USP36 was independent of its interaction with Snail2."
35111679
RPL31 affects USP36
2 |
RPL31 binds USP36. 2 / 2
2 |
biogrid
No evidence text available
34079125
biogrid
No evidence text available
36912080
RPL30 affects USP36
2 |
USP36 binds RPL30. 2 / 2
2 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
36912080
RPL10 affects USP36
2 |
RPL10 binds USP36. 2 / 2
2 |
biogrid
No evidence text available
26496610
biogrid
No evidence text available
36912080
Particulate Matter increases the amount of USP36. 2 / 2
2 |
ctd
No evidence text available
32579111
ctd
No evidence text available
38156290
PWP2 affects USP36
2 |
USP36 binds PWP2. 2 / 2
2 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
19615732
PTBP1 affects USP36
2 |
PTBP1 binds USP36. 2 / 2
2 |
biogrid
No evidence text available
35964538
biogrid
No evidence text available
35964538
POLR1G affects USP36
2 |
POLR1G binds USP36. 2 / 2
2 |
biogrid
No evidence text available
34079125
biogrid
No evidence text available
36912080
POLR1E affects USP36
2 |
POLR1E binds USP36. 2 / 2
2 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
34079125
NUDCD1 affects USP36
2 |
USP36 binds NUDCD1. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
36912080
NPM3 affects USP36
2 |
NPM3 binds USP36. 2 / 2
2 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
33961781
NOP10 affects USP36
2 |
USP36 binds NOP10. 2 / 2
2 |
biogrid
No evidence text available
33852194
biogrid
No evidence text available
36912080
NLE1 affects USP36
2 |
NLE1 binds USP36. 2 / 2
2 |
biogrid
No evidence text available
37689310
biogrid
No evidence text available
36912080
NIFK affects USP36
2 |
NIFK binds USP36. 2 / 2
2 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
34079125
NEDD4L affects USP36
| 1
USP36 binds NEDD4L. 1 / 2
| 1
reach
"Instead, USP36 binds to Nedd4-2 and regulates the association of TrkA and Nedd4-2."
27445338
MKI67 affects USP36
2 |
MKI67 binds USP36. 2 / 2
2 |
biogrid
No evidence text available
26949251
biogrid
No evidence text available
36912080
JQ1 affects USP36
| 2
JQ1 activates USP36. 2 / 2
| 2
reach
"These novel MYCN dependent pathways were obtained following an unbiased integration of RNA-seq datasets from CASC15-003, NBAT1, USP36, and MYCN knockdowns and NB cells treated with the MYCN inhibitor JQ1."
34056606
reach
"Unbiased integration of RNA-seq data from CASC15-003, NBAT1, USP36, and MYCN knockdowns and neuroblastoma cells treated with MYCN inhibitor JQ1, identified genes that are jointly regulated by the NBAT1/CASC15-003/USP36/MYCN pathway."
34056606
H4C16 affects USP36
2 |
H4C16 binds USP36. 2 / 2
2 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
30804502
Gentamicins affects USP36
2 |
Gentamicins increases the amount of USP36. 2 / 2
2 |
ctd
No evidence text available
20849824
ctd
No evidence text available
33387578
EZH2 affects USP36
2 |
USP36 binds EZH2. 2 / 2
2 |
biogrid
No evidence text available
31434700
biogrid
No evidence text available
31434700
EXOSC4 affects USP36
2 |
USP36 binds EXOSC4. 2 / 2
2 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
36912080
EXOSC3 affects USP36
2 |
USP36 binds EXOSC3. 2 / 2
2 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
36912080
EIF6 affects USP36
2 |
EIF6 binds USP36. 2 / 2
2 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
34079125
DKC1 affects USP36
2 |
USP36 binds DKC1. 2 / 2
2 |
biogrid
No evidence text available
36912080
biogrid
No evidence text available
33852194
DDX41 affects USP36
2 |
USP36 binds DDX41. 2 / 2
2 |
biogrid
No evidence text available
19615732
biogrid
No evidence text available
36912080
CREB1 affects USP36
2 |
CREB1 decreases the amount of USP36. 2 / 2
2 |
biopax:msigdb
No evidence text available
biopax:msigdb
No evidence text available
CEP63 affects USP36
2 |
CEP63 binds USP36. 2 / 2
2 |
biogrid
No evidence text available
35989368
biogrid
No evidence text available
35989368
ATG14 affects USP36
| 2
ATG14 activates USP36. 2 / 2
| 2
reach
"Thus, additional it is possible, that the reduction of ATG14L protein levels may result in failure of the final elimination of depolarized mitochondria (mitophagy), due to a compromised SNARE complex [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31550441
reach
"However, in USP36 silenced cells, the expression of ATG14L WT and S29D rescued mitophagy significantly, while ATG14L S29A failed ( Fig. 8 B)."
31550441
9c affects USP36
2 |
9c binds USP36. 2 / 2
2 |
biogrid
No evidence text available
| DOI
biogrid
No evidence text available
| DOI
Vorinostat affects USP36
1 |
Vorinostat decreases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
27188386
Thioacetamide affects USP36
1 |
Thioacetamide increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
34492290
ShRNA affects USP36
| 1
ShRNA inhibits USP36. 1 / 1
| 1
eidos
"Depletion of USP36 by shRNA in SK-N-BE ( 2 ) and IMR-32 resulted in a decrease in cell proliferation ( Figure 3A ) and reduced colony formation ( Figure 3B ) ."
34056606
Methapyrilene affects USP36
1 |
Methapyrilene methylates USP36. 1 / 1
1 |
ctd
No evidence text available
30157460
Lnc-HZ01 affects USP36
| 1
Lnc-HZ01 activates USP36. 1 / 1
| 1
reach
"Mechanistically, lnc-HZ01 promotes MXD1 mRNA transcription by up-regulating its transcription factor c-JUN and also enhances MXD1 protein stability by up-regulating its deubiquitin enzyme USP36."
33647641
Lipoprotein affects USP36
| 1
Lipoprotein activates USP36. 1 / 1
| 1
reach
"This study aimed to uncover the function and mechanism of circ-ubiquitin specific peptidase 36 (USP36) in endothelial cells treated with oxidized low-density lipoprotein (ox-LDL)."
33249762
Hsa-mir-4434 affects USP36
1 |
Hsa-mir-4434 decreases the amount of USP36. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-6770-5p affects USP36
1 |
Hsa-miR-6770-5p decreases the amount of USP36. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-615-3p affects USP36
1 |
Hsa-miR-615-3p decreases the amount of USP36. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-6124 affects USP36
1 |
Hsa-miR-6124 decreases the amount of USP36. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-582-5p affects USP36
1 |
Hsa-miR-582-5p decreases the amount of USP36. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-5703 affects USP36
1 |
Hsa-miR-5703 decreases the amount of USP36. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23592263
Hsa-miR-342-5p affects USP36
1 |
Hsa-miR-342-5p decreases the amount of USP36. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Hsa-miR-151a-3p affects USP36
1 |
Hsa-miR-151a-3p decreases the amount of USP36. 1 / 1
1 |
biopax:mirtarbase
No evidence text available
23622248
Geldanamycin affects USP36
1 |
Geldanamycin increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
26705709
Fenofibrate affects USP36
1 |
Fenofibrate decreases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
21318169
Epoxiconazole affects USP36
1 |
Epoxiconazole decreases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
35436446
Dimethylarsinous acid increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
23487506
Dicrotophos affects USP36
1 |
Dicrotophos increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
28302478
Crocidolite asbestos increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
18687144
Coumarin affects USP36
1 |
Coumarin phosphorylates USP36. 1 / 1
1 |
ctd
No evidence text available
35688186
Atrazine affects USP36
1 |
Atrazine decreases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
25929836
Arsenic atom affects USP36
1 |
Arsenic atom increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
32525701
Amphotericin B affects USP36
1 |
Amphotericin B increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
20849824
Alpha-phellandrene decreases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
25075043
Abrine affects USP36
1 |
Abrine increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
31054353
ZNF330 affects USP36
1 |
ZNF330 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
34079125
ZBTB44 affects USP36
1 |
ZBTB44 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
33961781
YAP1 affects USP domain
| 1
YAP1 binds USP36 and USP domain. 1 / 1
| 1
reach
"We made deletion constructs targeting these domains for interaction analysis, which revealed that the WW domain was necessary for the binding of YAP to USP36, while the USP domain was required for the association of USP36 with YAP (Fig. 5E, F)."
36470870
XRN2 affects USP36
1 |
USP36 binds XRN2. 1 / 1
1 |
biogrid
No evidence text available
36912080
WDR74 affects USP36
1 |
USP36 binds WDR74. 1 / 1
1 |
biogrid
No evidence text available
36912080
VIRMA affects USP36
1 |
VIRMA binds USP36. 1 / 1
1 |
biogrid
No evidence text available
29507755
UTP3 affects USP36
1 |
USP36 binds UTP3. 1 / 1
1 |
biogrid
No evidence text available
36912080
UTP20 affects USP36
1 |
USP36 binds UTP20. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects tumor growth
| 1
USP36 activates tumor growth. 1 / 1
| 1
eidos
"Moreover , the DUB USP7 , USP13 , USP22 , USP28 , USP36 and USP37 stabilize c-Myc , thereby stimulating tumor growth [ 155 , 157 , 171-174 ] ."
| PMC
USP36 affects temozolomide
| 1
USP36 inhibits temozolomide. 1 / 1
| 1
reach
"Depleting USP36 diminishes GSC self-renewal and increases their sensitivity to TMZ in vitro and in vivo [131]."
38702734
USP36 affects smo-1
| 1
USP36 activates smo-1. 1 / 1
| 1
reach
"In addition, USP36 deubiquitinase can physically interact with SUMO-2 and Ubc9 and promote SUMO conjugation with Nop56, Nop58, Nph2, and DKC1, eventually facilitating rRNA processing and translation (50)."
36195568
USP36 activates reactive oxygen species biosynthetic process. 1 / 1
| 1
reach
"As shown in Fig. 2 A, B , Dox treatment notably increased cellular ROS generation, which USP36 silencing decreased."
38307305
USP36 activates protein stabilization. 1 / 1
| 1
reach
"Mechanically, USP36 enhances c-Myc protein stabilization in HCT116 cells via deubiquitination."
38517383
USP36 affects polyubiquitination protein
| 1
USP36 activates polyubiquitination protein. 1 / 1
| 1
eidos
"Subsequent sub-screening identified 23 DUBs that interact with SNAI1 , out of which USP29 , USP36 , and USP37 upregulate and reduce polyubiquitination of the SNAI1 protein ."
| PMC
USP36 activates phosphatidylinositol 3-kinase/protein kinase B signal transduction. 1 / 1
| 1
reach
"In summary, these findings indicate that USP36 functions as a deubiquitinase to modulate PME-1 and promote the ERK and AKT signaling pathways (Figure 2E)."
38785979
USP36 affects miRNA processing
| 1
USP36 activates miRNA processing. 1 / 1
| 1
reach
"Knockdown of USP36 Attenuates miRNA Biogenesis."
36950067
USP36 affects malonaldehyde
| 1
USP36 decreases the amount of malonaldehyde. 1 / 1
| 1
reach
"Cardiac-knockdown of USP36 markedly reduced serum levels of MDA and LDH in cardiac tissue which were elevated by Dox treatment ( Fig. 6 I, J)."
38307305
USP36 affects macroautophagy
| 1
USP36 inhibits macroautophagy. 1 / 1
| 1
sparser
"USP36 can inhibit selective macroautophagy by preventing the accumulation of ubiquitinated proteins, but the specific substrates of USP36 (whose targeting to autophagosomes is affected) are not yet known [ xref ]."
26415220
USP36 activates glycolytic process. 1 / 1
| 1
reach
"USP36 can also regulate the ubiquitination level of PKM2, thereby increasing its protein expression, and promote glycolysis of breast cancer cells through the “Warburg effect” [57]."
37190313
USP36 affects c-Myc [
| 1
USP36 deubiquitinates c-Myc [. 1 / 1
| 1
reach
"In a subset of human breast and lung cancers, USP36 interacts with and deubiquitinates c-Myc [XREF_BIBR]."
29142505
USP36 affects ZNF330
1 |
ZNF330 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
34079125
USP36 affects ZBTB44
1 |
ZBTB44 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP36 affects XRN2
1 |
USP36 binds XRN2. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects WDR74
1 |
USP36 binds WDR74. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects VIRMA
1 |
VIRMA binds USP36. 1 / 1
1 |
biogrid
No evidence text available
29507755
USP36 affects UTP3
1 |
USP36 binds UTP3. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects UTP20
1 |
USP36 binds UTP20. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects USP16
| 1
USP36 binds USP16. 1 / 1
| 1
sparser
"Binding of USP36 or USP16 to Fubi-PA led to pronounced protein stabilization as assessed by an increase in melting temperature, while binding to ubiquitin-PA for USP36, USP16 and USP2 correlated with even larger protein stability (Fig. xref )."
37443395
USP36 affects USP domain
| 1
YAP1 binds USP36 and USP domain. 1 / 1
| 1
reach
"We made deletion constructs targeting these domains for interaction analysis, which revealed that the WW domain was necessary for the binding of YAP to USP36, while the USP domain was required for the association of USP36 with YAP (Fig. 5E, F)."
36470870
USP36 affects URB1
1 |
USP36 binds URB1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects TUBB4B
1 |
USP36 binds TUBB4B. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects TUBB3
1 |
USP36 binds TUBB3. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects TUBB2A
1 |
USP36 binds TUBB2A. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects TRIM28
1 |
USP36 binds TRIM28. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects TRAMP
| 1
USP36 binds TRAMP. 1 / 1
| 1
sparser
"We indeed observed that USP36 interacts with the TRAMP complex (data not shown)."
36912080
USP36 affects TOP2A
1 |
USP36 binds TOP2A. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects TKT
1 |
USP36 binds TKT. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects TEX10
1 |
USP36 binds TEX10. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects TEFM
1 |
USP36 binds TEFM. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects TALDO1
1 |
USP36 binds TALDO1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects Snai11
| 1
USP36 increases the amount of Snai11. 1 / 1
| 1
reach
"Consistently, USP36 upregulated expression of Snai11 , but not Snail1 (Fig. 4g)."
37833415
USP36 affects SURF6
1 |
USP36 binds SURF6. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects SUMO2
1 |
USP36 binds SUMO2. 1 / 1
1 |
biogrid
No evidence text available
33852194
USP36 affects SRPK1
1 |
USP36 binds SRPK1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects SQSTM1
| 1
USP36 inhibits SQSTM1. 1 / 1
| 1
reach
"Another recent study demonstrated that the deubiquitinating enzyme Usp36, which had been shown to negatively regulate the IMD pathway in flies, also negatively regulates p62 dependent selective autophagy in flies and human cells [XREF_BIBR]."
23689401
USP36 affects SNRNP40
1 |
SNRNP40 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
37689310
USP36 affects SLX9
1 |
USP36 binds SLX9. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects SCYL2
1 |
USP36 binds SCYL2. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RSL1D1
1 |
USP36 binds RSL1D1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RSBN1L
1 |
USP36 binds RSBN1L. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RRS1
1 |
USP36 binds RRS1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RRP15
1 |
USP36 binds RRP15. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RRP12
1 |
USP36 binds RRP12. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RRP1
1 |
USP36 binds RRP1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RPSA
1 |
USP36 binds RPSA. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RPS8
1 |
USP36 binds RPS8. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RPS4X
1 |
USP36 binds RPS4X. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RPS26
1 |
USP36 binds RPS26. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RPS23
1 |
USP36 binds RPS23. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RPS2
1 |
USP36 binds RPS2. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RPS19BP1
1 |
USP36 binds RPS19BP1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RPS19
1 |
USP36 binds RPS19. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RPS18
1 |
USP36 binds RPS18. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RPS17
1 |
USP36 binds RPS17. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RPS10
1 |
USP36 binds RPS10. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RPLP1
1 |
USP36 binds RPLP1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RPL7A
1 |
USP36 binds RPL7A. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RPL37A
1 |
USP36 binds RPL37A. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RPL37
1 |
USP36 binds RPL37. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RPL27A
1 |
USP36 binds RPL27A. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RPL27
1 |
USP36 binds RPL27. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RPL21
1 |
USP36 binds RPL21. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RPL18
1 |
USP36 binds RPL18. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RPL15
1 |
USP36 binds RPL15. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RPL14
1 |
USP36 binds RPL14. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RPL12
1 |
USP36 binds RPL12. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RPL10L
1 |
USP36 binds RPL10L. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RPA2
1 |
RPA2 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
37827155
USP36 affects RPA1
1 |
RPA1 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
37827155
USP36 affects RNF145
1 |
RNF145 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP36 affects RND1
1 |
RND1 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
31871319
USP36 affects RIF1
1 |
USP36 binds RIF1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects REXO4
1 |
USP36 binds REXO4. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RBM4B
1 |
USP36 binds RBM4B. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RBM34
1 |
USP36 binds RBM34. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects RBM28.Next
| 1
USP36 binds RBM28.Next. 1 / 1
| 1
reach
"These findings suggest an interaction between USP36 and RBM28.Next, we proceeded to investigate whether the expression levels of RBM28 are modulated by USP36."
39343961
USP36 affects RBM27
1 |
USP36 binds RBM27. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects Protein Stability
| 1
USP36 activates Protein Stability. 1 / 1
| 1
eidos
"USP36 deubiquitinates K29-linked polyubiquitination of PrimPol and increases its protein stability ."
33237263
USP36 affects PURB
1 |
USP36 binds PURB. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects PSMD4
1 |
USP36 binds PSMD4. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects PSMD3
1 |
USP36 binds PSMD3. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects PRPF8
1 |
USP36 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects PRKDC
1 |
USP36 binds PRKDC. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects PPT1
1 |
USP36 binds PPT1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects PPAN
1 |
USP36 binds PPAN. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects PNO1
1 |
USP36 binds PNO1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects PINK1
1 |
PINK1 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
31300519
USP36 affects PFN1
1 |
USP36 binds PFN1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects PDCD11
1 |
USP36 binds PDCD11. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects PBRM1
1 |
USP36 binds PBRM1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects ODR4
1 |
USP36 binds ODR4. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects NVL
1 |
USP36 binds NVL. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects NUSAP1
1 |
USP36 binds NUSAP1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects NSCLC
| 1
USP36 activates NSCLC. 1 / 1
| 1
reach
"Overexpression of USP36 promoted NSCLC cell proliferation and inhibited NSCLC cell apoptosis."
35133629
USP36 affects NOTCH1
1 |
USP36 binds NOTCH1. 1 / 1
1 |
biogrid
No evidence text available
37714834
USP36 affects NOP16
1 |
USP36 binds NOP16. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects NOLC1
1 |
USP36 binds NOLC1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects NOL6
1 |
USP36 binds NOL6. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects NGDN
1 |
USP36 binds NGDN. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects NCL
1 |
USP36 binds NCL. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects NAT10
1 |
USP36 binds NAT10. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects Mice
| 1
USP36 inhibits Mice. 1 / 1
| 1
reach
"For example, loss of the deubiquitinating enzyme USP36 causes preimplantation embryonic lethality in mice by modulating the stability of DHX33 [12]."
38769534
USP36 affects MYO6
1 |
USP36 binds MYO6. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects MYH9
1 |
USP36 binds MYH9. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects MYEF2
1 |
USP36 binds MYEF2. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects MRPS5
1 |
USP36 binds MRPS5. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects MRPS18B
1 |
USP36 binds MRPS18B. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects MRPL47
1 |
USP36 binds MRPL47. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects MPO
1 |
USP36 binds MPO. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects MMP9
1 |
USP36 binds MMP9. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects MIR29C
1 |
MIR29C binds USP36. 1 / 1
1 |
biogrid
No evidence text available
28431233
USP36 affects MIR19B2
1 |
MIR19B2 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
28431233
USP36 affects MIR17
1 |
MIR17 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
28431233
USP36 affects MIR16-1
1 |
MIR16-1 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
28431233
USP36 affects MEIS1
| 1
Modified USP36 increases the amount of MEIS1. 1 / 1
| 1
reach
"Transcription levels of JMJD6, HSPA1A, WDR6, and MEIS1 were up-regulated by RE-IIBP overexpression and USP36 level was not changed (XREF_SUPPLEMENTARY)."
26206755
USP36 affects MCM7
1 |
USP36 binds MCM7. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects MAT2A
1 |
USP36 binds MAT2A. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects MACROH2A2
1 |
USP36 binds MACROH2A2. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects MACROH2A1
1 |
USP36 binds MACROH2A1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects LLPH
1 |
USP36 binds LLPH. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects LINC02910
1 |
LINC02910 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP36 affects LIN28B
1 |
USP36 binds LIN28B. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP36 affects LDH
| 1
USP36 decreases the amount of LDH. 1 / 1
| 1
reach
"Cardiac-knockdown of USP36 markedly reduced serum levels of MDA and LDH in cardiac tissue which were elevated by Dox treatment ( Fig. 6 I, J)."
38307305
USP36 affects LCP1
1 |
USP36 binds LCP1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects LARP7
1 |
USP36 binds LARP7. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects Kif18b
1 |
USP36 binds Kif18b. 1 / 1
1 |
biogrid
No evidence text available
34133714
USP36 affects Ki67 staining
| 1
USP36 activates Ki67 staining. 1 / 1
| 1
eidos
"Depletion of USP36 significantly reduced the tumor weight , tumor volume and Ki67 staining , indicating that USP36 harbors oncogenic properties ( Figure 3C and D ) ."
34056606
USP36 affects KRT84
1 |
USP36 binds KRT84. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects KRR1
1 |
USP36 binds KRR1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects KRI1
1 |
USP36 binds KRI1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects KPNA3
1 |
USP36 binds KPNA3. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects KNOP1
1 |
USP36 binds KNOP1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects K48-ubiquitin chains
| 1
USP36 activates K48-ubiquitin chains. 1 / 1
| 1
reach
"USP36 removes K63-polyubiquitin chains from IMD and then appears to increase the addition of K48-ubiquitin chains and degradation of IMD."
20852987
USP36 affects K29-linked polyubiquitination PrimPol
| 1
USP36 inhibits K29-linked polyubiquitination PrimPol. 1 / 1
| 1
eidos
"We further examined these linkages ( Ub-K11 , Ub-K27 or Ub-K29 ) with or without USP36 knock-down , and found that USP36 depletion only increased K29-linked polyubiquitination of PrimPol ( Figure 5A , and Supplementary Figure S6B ) ."
33237263
USP36 affects JNK
| 1
USP36 activates JNK. 1 / 1
| 1
reach
"We thus speculated that ribotoxic stress promotes USP36 expression via activating the JNK/p38 signaling."
37833415
USP36 affects JMJD6
| 1
Modified USP36 increases the amount of JMJD6. 1 / 1
| 1
reach
"Transcription levels of JMJD6, HSPA1A, WDR6, and MEIS1 were up-regulated by RE-IIBP overexpression and USP36 level was not changed (XREF_SUPPLEMENTARY)."
26206755
USP36 affects IRS4
1 |
USP36 binds IRS4. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects IR-induced DGCR8
| 1
USP36 activates IR-induced DGCR8. 1 / 1
| 1
eidos
"In both LM2 and MCF-7 cells , IR-induced upregulation of DGCR8 was reversed by shRNA-mediated knockdown of USP51 , but not by knockdown of USP36 ( Fig. 5b and Supplementary Fig. 5a ) ."
34188037
USP36 affects IMMT
1 |
USP36 binds IMMT. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects IGLC2
1 |
USP36 binds IGLC2. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects IGKC
1 |
USP36 binds IGKC. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects IFI27L1
1 |
IFI27L1 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP36 affects HP
1 |
USP36 binds HP. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects HIF1A
| 1
USP36 activates HIF1A. 1 / 1
| 1
reach
"We, therefore, analyzed the expression of Cezanne, a deubiquitinating enzyme 36 that can rescue HIF1alpha from VHL mediated degradation by cleaving ubiquitin from it."
28882872
USP36 affects HDAC2
1 |
USP36 binds HDAC2. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects HDAC1
1 |
USP36 binds HDAC1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects H3C12
1 |
USP36 binds H3C12. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects H2BC12
1 |
USP36 binds H2BC12. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects GTF3C5
1 |
USP36 binds GTF3C5. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects GTF3C3
1 |
USP36 binds GTF3C3. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects GTF3C2
1 |
USP36 binds GTF3C2. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects GTF3C1
1 |
USP36 binds GTF3C1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects GST
| 1
USP36 binds GST. 1 / 1
| 1
sparser
"GST PD assays showed that the recombinant His-tagged Lasso domain of EXOSC10 protein purified from bacteria was specifically bound by the purified GST-fused C-terminus of USP36 (GST–USP36 801–1121 ), but not by GST alone ( xref )."
36912080
USP36 affects GSN
1 |
USP36 binds GSN. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects GRWD1
1 |
USP36 binds GRWD1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects GRSF1
1 |
USP36 binds GRSF1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects GLYR1
1 |
USP36 binds GLYR1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects GAGE2E
1 |
GAGE2E binds USP36. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP36 affects Fbw7α
| 1
USP36 binds Fbw7α. 1 / 1
| 1
sparser
"Notably, USP36 interacts with the nucleolar Fbw7γ but not the nucleoplasmic Fbw7α."
31832515
USP36 affects FCF1
1 |
USP36 binds FCF1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects EXOSC9
1 |
USP36 binds EXOSC9. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects EMG1
1 |
USP36 binds EMG1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects ELOA
1 |
USP36 binds ELOA. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects EIF5B
1 |
USP36 binds EIF5B. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects EEF2
1 |
USP36 binds EEF2. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects EED
1 |
EED binds USP36. 1 / 1
1 |
biogrid
No evidence text available
37689310
USP36 affects EBNA1BP2
1 |
USP36 binds EBNA1BP2. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects DPM1
1 |
USP36 binds DPM1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects DNTTIP2
1 |
USP36 binds DNTTIP2. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects DNAJA2
1 |
USP36 binds DNAJA2. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects DNAJA1
1 |
USP36 binds DNAJA1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects DNA damage-tolerant polymerase
| 1
USP36 deubiquitinates DNA damage-tolerant polymerase. 1 / 1
| 1
reach
"USP36 deubiquitinates and regulates the stability of PrimPol, a DNA damage-tolerant polymerase (Figure 2D) [108]."
37107644
USP36 affects DIMT1
1 |
USP36 binds DIMT1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects DHX8
1 |
USP36 binds DHX8. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects DHE
| 1
USP36 inhibits DHE. 1 / 1
| 1
reach
"The DHE staining assay indicated that PARP1 overexpression could at least partially reverse the decrease in the number of DHE-positive cells induced by USP36 knockdown ( Fig. 5 B)."
38307305
USP36 affects DDX54
1 |
USP36 binds DDX54. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects DDX52
1 |
USP36 binds DDX52. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects DDX50
1 |
USP36 binds DDX50. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects DDX49
1 |
USP36 binds DDX49. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects DDX3X
1 |
USP36 binds DDX3X. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects DDX28
1 |
USP36 binds DDX28. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects DDX27
1 |
USP36 binds DDX27. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects DDX24
1 |
USP36 binds DDX24. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects DDX21
1 |
USP36 binds DDX21. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects DARS1
1 |
USP36 binds DARS1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects CTNNB1
1 |
USP36 binds CTNNB1. 1 / 1
1 |
biogrid
No evidence text available
30323974
USP36 affects CRISP3
1 |
USP36 binds CRISP3. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects COX8A
1 |
COX8A binds USP36. 1 / 1
1 |
biogrid
No evidence text available
34079125
USP36 affects CORO1C
1 |
USP36 binds CORO1C. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects CORO1A
1 |
USP36 binds CORO1A. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects COIL
1 |
USP36 binds COIL. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects CMAS
1 |
USP36 binds CMAS. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects CFAP141
1 |
CFAP141 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP36 affects CENPA
1 |
CENPA binds USP36. 1 / 1
1 |
biogrid
No evidence text available
34079125
USP36 affects CDK13
1 |
USP36 binds CDK13. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects CDC14B
1 |
CDC14B binds USP36. 1 / 1
1 |
biogrid
No evidence text available
27880917
USP36 affects CCT4
1 |
USP36 binds CCT4. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects CCT3
1 |
USP36 binds CCT3. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects CCT2
1 |
USP36 binds CCT2. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects CCN2
| 1
USP36 activates CCN2. 1 / 1
| 1
reach
"The qPCR data showed that USP36 overexpression enhanced the expression of Hippo target genes, including CTGF (NM_001901.4) and CYR61 (Fig. 2G)."
36470870
USP36 affects CCDC88A
1 |
USP36 binds CCDC88A. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects CCDC137
1 |
USP36 binds CCDC137. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects CASP7
| 1
USP36 inhibits CASP7. 1 / 1
| 1
reach
"Both cIAP1 and survivin prevented the cleavage of caspase-7 caused by USP36 knockdown."
38876304
USP36 affects CAMP
1 |
USP36 binds CAMP. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects CAD
1 |
USP36 binds CAD. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects C7orf50
1 |
USP36 binds C7orf50. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects C-MYC
| 1
USP36 deubiquitinates C-MYC. 1 / 1
| 1
trips
"USP36 interacts with and deubiquitinates c-Myc in cells and in vitro, leading to the stabilization of c-Myc."
25775507
USP36 affects BYSL
1 |
USP36 binds BYSL. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects BCL2L1
| 1
BCL2L1 binds USP36. 1 / 1
| 1
sparser
"Finally, we determined the association of USP36 with Bcl-xL, p65, Mcl-1, and XIAP via coimmunoprecipitation in HEK-293 cells and observed no interactions ( xref , E – G )."
38876304
USP36 affects B23
| 1
USP36 deubiquitinates B23. 1 / 1
| 1
reach
"USP36 deubiquitylated the nucleolar proteins nucleophosmin and B23 and fibrillarin, and stabilized them by counteracting ubiquitylation mediated proteasomal degradation."
19208757
USP36 affects ATP5F1A
1 |
USP36 binds ATP5F1A. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects ATP2A2
1 |
USP36 binds ATP2A2. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects ATAD3B
1 |
USP36 binds ATAD3B. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects ANKRD52
1 |
USP36 binds ANKRD52. 1 / 1
1 |
biogrid
No evidence text available
19615732
USP36 affects ALYREF
1 |
USP36 binds ALYREF. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects AKAP8L
1 |
USP36 binds AKAP8L. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects AIFM1
1 |
USP36 binds AIFM1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects AIF1
1 |
AIF1 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
33961781
USP36 affects ADARB1
1 |
ADARB1 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
32433965
USP36 affects ABT1
1 |
USP36 binds ABT1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP36 affects ABCF1
1 |
USP36 binds ABCF1. 1 / 1
1 |
biogrid
No evidence text available
36912080
USP16 affects USP36
| 1
USP36 binds USP16. 1 / 1
| 1
sparser
"Binding of USP36 or USP16 to Fubi-PA led to pronounced protein stabilization as assessed by an increase in melting temperature, while binding to ubiquitin-PA for USP36, USP16 and USP2 correlated with even larger protein stability (Fig. xref )."
37443395
USP domain affects YAP1
| 1
YAP1 binds USP36 and USP domain. 1 / 1
| 1
reach
"We made deletion constructs targeting these domains for interaction analysis, which revealed that the WW domain was necessary for the binding of YAP to USP36, while the USP domain was required for the association of USP36 with YAP (Fig. 5E, F)."
36470870
URB1 affects USP36
1 |
USP36 binds URB1. 1 / 1
1 |
biogrid
No evidence text available
36912080
TUBB4B affects USP36
1 |
USP36 binds TUBB4B. 1 / 1
1 |
biogrid
No evidence text available
36912080
TUBB3 affects USP36
1 |
USP36 binds TUBB3. 1 / 1
1 |
biogrid
No evidence text available
36912080
TUBB2A affects USP36
1 |
USP36 binds TUBB2A. 1 / 1
1 |
biogrid
No evidence text available
36912080
TRIM28 affects USP36
1 |
USP36 binds TRIM28. 1 / 1
1 |
biogrid
No evidence text available
36912080
TRAMP affects USP36
| 1
USP36 binds TRAMP. 1 / 1
| 1
sparser
"We indeed observed that USP36 interacts with the TRAMP complex (data not shown)."
36912080
TOP2A affects USP36
1 |
USP36 binds TOP2A. 1 / 1
1 |
biogrid
No evidence text available
36912080
TKT affects USP36
1 |
USP36 binds TKT. 1 / 1
1 |
biogrid
No evidence text available
36912080
TEX10 affects USP36
1 |
USP36 binds TEX10. 1 / 1
1 |
biogrid
No evidence text available
36912080
TEFM affects USP36
1 |
USP36 binds TEFM. 1 / 1
1 |
biogrid
No evidence text available
36912080
TALDO1 affects USP36
1 |
USP36 binds TALDO1. 1 / 1
1 |
biogrid
No evidence text available
36912080
Smoke affects USP36
1 |
Smoke increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
38245732
SURF6 affects USP36
1 |
USP36 binds SURF6. 1 / 1
1 |
biogrid
No evidence text available
36912080
SUMO2 affects USP36
1 |
USP36 binds SUMO2. 1 / 1
1 |
biogrid
No evidence text available
33852194
SRPK1 affects USP36
1 |
USP36 binds SRPK1. 1 / 1
1 |
biogrid
No evidence text available
36912080
SNRNP40 affects USP36
1 |
SNRNP40 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
37689310
SLX9 affects USP36
1 |
USP36 binds SLX9. 1 / 1
1 |
biogrid
No evidence text available
36912080
SCYL2 affects USP36
1 |
USP36 binds SCYL2. 1 / 1
1 |
biogrid
No evidence text available
36912080
RSL1D1 affects USP36
1 |
USP36 binds RSL1D1. 1 / 1
1 |
biogrid
No evidence text available
36912080
RSBN1L affects USP36
1 |
USP36 binds RSBN1L. 1 / 1
1 |
biogrid
No evidence text available
36912080
RRS1 affects USP36
1 |
USP36 binds RRS1. 1 / 1
1 |
biogrid
No evidence text available
36912080
RRP15 affects USP36
1 |
USP36 binds RRP15. 1 / 1
1 |
biogrid
No evidence text available
36912080
RRP12 affects USP36
1 |
USP36 binds RRP12. 1 / 1
1 |
biogrid
No evidence text available
36912080
RRP1 affects USP36
1 |
USP36 binds RRP1. 1 / 1
1 |
biogrid
No evidence text available
36912080
RPSA affects USP36
1 |
USP36 binds RPSA. 1 / 1
1 |
biogrid
No evidence text available
36912080
RPS8 affects USP36
1 |
USP36 binds RPS8. 1 / 1
1 |
biogrid
No evidence text available
36912080
RPS4X affects USP36
1 |
USP36 binds RPS4X. 1 / 1
1 |
biogrid
No evidence text available
36912080
RPS26 affects USP36
1 |
USP36 binds RPS26. 1 / 1
1 |
biogrid
No evidence text available
36912080
RPS23 affects USP36
1 |
USP36 binds RPS23. 1 / 1
1 |
biogrid
No evidence text available
36912080
RPS2 affects USP36
1 |
USP36 binds RPS2. 1 / 1
1 |
biogrid
No evidence text available
36912080
RPS19BP1 affects USP36
1 |
USP36 binds RPS19BP1. 1 / 1
1 |
biogrid
No evidence text available
36912080
RPS19 affects USP36
1 |
USP36 binds RPS19. 1 / 1
1 |
biogrid
No evidence text available
36912080
RPS18 affects USP36
1 |
USP36 binds RPS18. 1 / 1
1 |
biogrid
No evidence text available
36912080
RPS17 affects USP36
1 |
USP36 binds RPS17. 1 / 1
1 |
biogrid
No evidence text available
36912080
RPS10 affects USP36
1 |
USP36 binds RPS10. 1 / 1
1 |
biogrid
No evidence text available
36912080
RPLP1 affects USP36
1 |
USP36 binds RPLP1. 1 / 1
1 |
biogrid
No evidence text available
36912080
RPL7A affects USP36
1 |
USP36 binds RPL7A. 1 / 1
1 |
biogrid
No evidence text available
36912080
RPL37A affects USP36
1 |
USP36 binds RPL37A. 1 / 1
1 |
biogrid
No evidence text available
36912080
RPL37 affects USP36
1 |
USP36 binds RPL37. 1 / 1
1 |
biogrid
No evidence text available
36912080
RPL27A affects USP36
1 |
USP36 binds RPL27A. 1 / 1
1 |
biogrid
No evidence text available
36912080
RPL27 affects USP36
1 |
USP36 binds RPL27. 1 / 1
1 |
biogrid
No evidence text available
36912080
RPL21 affects USP36
1 |
USP36 binds RPL21. 1 / 1
1 |
biogrid
No evidence text available
36912080
RPL18 affects USP36
1 |
USP36 binds RPL18. 1 / 1
1 |
biogrid
No evidence text available
36912080
RPL15 affects USP36
1 |
USP36 binds RPL15. 1 / 1
1 |
biogrid
No evidence text available
36912080
RPL14 affects USP36
1 |
USP36 binds RPL14. 1 / 1
1 |
biogrid
No evidence text available
36912080
RPL12 affects USP36
1 |
USP36 binds RPL12. 1 / 1
1 |
biogrid
No evidence text available
36912080
RPL10L affects USP36
1 |
USP36 binds RPL10L. 1 / 1
1 |
biogrid
No evidence text available
36912080
RPA2 affects USP36
1 |
RPA2 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
37827155
RPA1 affects USP36
1 |
RPA1 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
37827155
RNF145 affects USP36
1 |
RNF145 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
33961781
RND1 affects USP36
1 |
RND1 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
31871319
RIF1 affects USP36
1 |
USP36 binds RIF1. 1 / 1
1 |
biogrid
No evidence text available
36912080
REXO4 affects USP36
1 |
USP36 binds REXO4. 1 / 1
1 |
biogrid
No evidence text available
36912080
RBM4B affects USP36
1 |
USP36 binds RBM4B. 1 / 1
1 |
biogrid
No evidence text available
36912080
RBM34 affects USP36
1 |
USP36 binds RBM34. 1 / 1
1 |
biogrid
No evidence text available
36912080
RBM28.Next affects USP36
| 1
USP36 binds RBM28.Next. 1 / 1
| 1
reach
"These findings suggest an interaction between USP36 and RBM28.Next, we proceeded to investigate whether the expression levels of RBM28 are modulated by USP36."
39343961
RBM27 affects USP36
1 |
USP36 binds RBM27. 1 / 1
1 |
biogrid
No evidence text available
36912080
PURB affects USP36
1 |
USP36 binds PURB. 1 / 1
1 |
biogrid
No evidence text available
36912080
PSMD4 affects USP36
1 |
USP36 binds PSMD4. 1 / 1
1 |
biogrid
No evidence text available
36912080
PSMD3 affects USP36
1 |
USP36 binds PSMD3. 1 / 1
1 |
biogrid
No evidence text available
36912080
PRPF8 affects USP36
1 |
USP36 binds PRPF8. 1 / 1
1 |
biogrid
No evidence text available
36912080
PRKDC affects USP36
1 |
USP36 binds PRKDC. 1 / 1
1 |
biogrid
No evidence text available
36912080
PPT1 affects USP36
1 |
USP36 binds PPT1. 1 / 1
1 |
biogrid
No evidence text available
36912080
PPAN affects USP36
1 |
USP36 binds PPAN. 1 / 1
1 |
biogrid
No evidence text available
36912080
PNO1 affects USP36
1 |
USP36 binds PNO1. 1 / 1
1 |
biogrid
No evidence text available
36912080
PINK1 affects USP36
1 |
PINK1 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
31300519
PFN1 affects USP36
1 |
USP36 binds PFN1. 1 / 1
1 |
biogrid
No evidence text available
36912080
PDCD11 affects USP36
1 |
USP36 binds PDCD11. 1 / 1
1 |
biogrid
No evidence text available
36912080
PCI 5002 affects USP36
1 |
PCI 5002 increases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
18593933
PBRM1 affects USP36
1 |
USP36 binds PBRM1. 1 / 1
1 |
biogrid
No evidence text available
36912080
ODR4 affects USP36
1 |
USP36 binds ODR4. 1 / 1
1 |
biogrid
No evidence text available
36912080
Nanotubes, Carbon affects USP36
1 |
Nanotubes, Carbon decreases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
25554681
NVL affects USP36
1 |
USP36 binds NVL. 1 / 1
1 |
biogrid
No evidence text available
36912080
NUSAP1 affects USP36
1 |
USP36 binds NUSAP1. 1 / 1
1 |
biogrid
No evidence text available
36912080
NOTCH1 affects USP36
1 |
USP36 binds NOTCH1. 1 / 1
1 |
biogrid
No evidence text available
37714834
NOP16 affects USP36
1 |
USP36 binds NOP16. 1 / 1
1 |
biogrid
No evidence text available
36912080
NOLC1 affects USP36
1 |
USP36 binds NOLC1. 1 / 1
1 |
biogrid
No evidence text available
36912080
NOL6 affects USP36
1 |
USP36 binds NOL6. 1 / 1
1 |
biogrid
No evidence text available
36912080
NGDN affects USP36
1 |
USP36 binds NGDN. 1 / 1
1 |
biogrid
No evidence text available
36912080
NCL affects USP36
1 |
USP36 binds NCL. 1 / 1
1 |
biogrid
No evidence text available
36912080
NBAT1 affects USP36
| 1
NBAT1 activates USP36. 1 / 1
| 1
reach
"Though CASC15-003 and NBAT1 can modulate the USP36 nucleolar localization and CHD7 stability, lack of the differentiation phenotype upon depletion of any one of them suggests that both lncRNAs are req[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
29533783
NAT10 affects USP36
1 |
USP36 binds NAT10. 1 / 1
1 |
biogrid
No evidence text available
36912080
Mice affects USP36
| 1
Mice inhibits USP36. 1 / 1
| 1
reach
"Both H&E staining and Masson's trichrome staining results showed that the damage to the myocardium caused by Dox was significantly improved in cardiac USP36 knockdown mice ( Fig. 6 H)."
38307305
MYO6 affects USP36
1 |
USP36 binds MYO6. 1 / 1
1 |
biogrid
No evidence text available
36912080
MYH9 affects USP36
1 |
USP36 binds MYH9. 1 / 1
1 |
biogrid
No evidence text available
36912080
MYEF2 affects USP36
1 |
USP36 binds MYEF2. 1 / 1
1 |
biogrid
No evidence text available
36912080
MXD1 affects USP36
| 1
MXD1 activates USP36. 1 / 1
| 1
reach
"Mechanistically, lnc-HZ01 promotes MXD1 mRNA transcription by up-regulating its transcription factor c-JUN and also enhances MXD1 protein stability by up-regulating its deubiquitin enzyme USP36."
33647641
MRPS5 affects USP36
1 |
USP36 binds MRPS5. 1 / 1
1 |
biogrid
No evidence text available
36912080
MRPS18B affects USP36
1 |
USP36 binds MRPS18B. 1 / 1
1 |
biogrid
No evidence text available
36912080
MRPL47 affects USP36
1 |
USP36 binds MRPL47. 1 / 1
1 |
biogrid
No evidence text available
36912080
MPO affects USP36
1 |
USP36 binds MPO. 1 / 1
1 |
biogrid
No evidence text available
36912080
MMP9 affects USP36
1 |
USP36 binds MMP9. 1 / 1
1 |
biogrid
No evidence text available
36912080
MIR29C affects USP36
1 |
MIR29C binds USP36. 1 / 1
1 |
biogrid
No evidence text available
28431233
MIR19B2 affects USP36
1 |
MIR19B2 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
28431233
MIR17 affects USP36
1 |
MIR17 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
28431233
MIR16-1 affects USP36
1 |
MIR16-1 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
28431233
MCM7 affects USP36
1 |
USP36 binds MCM7. 1 / 1
1 |
biogrid
No evidence text available
36912080
MAT2A affects USP36
1 |
USP36 binds MAT2A. 1 / 1
1 |
biogrid
No evidence text available
36912080
MAPK8 affects USP36
| 1
MAPK8 increases the amount of USP36. 1 / 1
| 1
reach
"Notably, ectopic expression of JNK1 upregulated HSF1 expression as well as USP36 and Snail1 expression (Supplementary Fig. S6e)."
37833415
MACROH2A2 affects USP36
1 |
USP36 binds MACROH2A2. 1 / 1
1 |
biogrid
No evidence text available
36912080
MACROH2A1 affects USP36
1 |
USP36 binds MACROH2A1. 1 / 1
1 |
biogrid
No evidence text available
36912080
LLPH affects USP36
1 |
USP36 binds LLPH. 1 / 1
1 |
biogrid
No evidence text available
36912080
LINC02910 affects USP36
1 |
LINC02910 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
33961781
LIN28B affects USP36
1 |
USP36 binds LIN28B. 1 / 1
1 |
biogrid
No evidence text available
19615732
LCP1 affects USP36
1 |
USP36 binds LCP1. 1 / 1
1 |
biogrid
No evidence text available
36912080
LARP7 affects USP36
1 |
USP36 binds LARP7. 1 / 1
1 |
biogrid
No evidence text available
36912080
Kif18b affects USP36
1 |
USP36 binds Kif18b. 1 / 1
1 |
biogrid
No evidence text available
34133714
KRT84 affects USP36
1 |
USP36 binds KRT84. 1 / 1
1 |
biogrid
No evidence text available
36912080
KRR1 affects USP36
1 |
USP36 binds KRR1. 1 / 1
1 |
biogrid
No evidence text available
36912080
KRI1 affects USP36
1 |
USP36 binds KRI1. 1 / 1
1 |
biogrid
No evidence text available
36912080
KPNA3 affects USP36
1 |
USP36 binds KPNA3. 1 / 1
1 |
biogrid
No evidence text available
36912080
KNOP1 affects USP36
1 |
USP36 binds KNOP1. 1 / 1
1 |
biogrid
No evidence text available
36912080
KHK-A affects USP36
| 1
KHK-A inhibits USP36. 1 / 1
| 1
reach
"Overexpression of hnRNPH1/H2 reversed the downregulation of KHK-A induced inhibition of USP36."
35133629
IRS4 affects USP36
1 |
USP36 binds IRS4. 1 / 1
1 |
biogrid
No evidence text available
36912080
IMMT affects USP36
1 |
USP36 binds IMMT. 1 / 1
1 |
biogrid
No evidence text available
36912080
IGLC2 affects USP36
1 |
USP36 binds IGLC2. 1 / 1
1 |
biogrid
No evidence text available
36912080
IGKC affects USP36
1 |
USP36 binds IGKC. 1 / 1
1 |
biogrid
No evidence text available
36912080
IFI27L1 affects USP36
1 |
IFI27L1 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
33961781
HSF1 affects USP36
| 1
HSF1 increases the amount of USP36. 1 / 1
| 1
reach
"In addition, the pharmacological inhibition of HSF1 by KRIBB11 dramatically inhibited USP36 and Snail1 expression (Supplementary Fig. S6g)."
37833415
HP affects USP36
1 |
USP36 binds HP. 1 / 1
1 |
biogrid
No evidence text available
36912080
HDAC2 affects USP36
1 |
USP36 binds HDAC2. 1 / 1
1 |
biogrid
No evidence text available
36912080
HDAC1 affects USP36
1 |
USP36 binds HDAC1. 1 / 1
1 |
biogrid
No evidence text available
36912080
H3C12 affects USP36
1 |
USP36 binds H3C12. 1 / 1
1 |
biogrid
No evidence text available
36912080
H2BC12 affects USP36
1 |
USP36 binds H2BC12. 1 / 1
1 |
biogrid
No evidence text available
36912080
GTF3C5 affects USP36
1 |
USP36 binds GTF3C5. 1 / 1
1 |
biogrid
No evidence text available
36912080
GTF3C3 affects USP36
1 |
USP36 binds GTF3C3. 1 / 1
1 |
biogrid
No evidence text available
36912080
GTF3C2 affects USP36
1 |
USP36 binds GTF3C2. 1 / 1
1 |
biogrid
No evidence text available
36912080
GTF3C1 affects USP36
1 |
USP36 binds GTF3C1. 1 / 1
1 |
biogrid
No evidence text available
36912080
GST affects USP36
| 1
USP36 binds GST. 1 / 1
| 1
sparser
"GST PD assays showed that the recombinant His-tagged Lasso domain of EXOSC10 protein purified from bacteria was specifically bound by the purified GST-fused C-terminus of USP36 (GST–USP36 801–1121 ), but not by GST alone ( xref )."
36912080
GSN affects USP36
1 |
USP36 binds GSN. 1 / 1
1 |
biogrid
No evidence text available
36912080
GRWD1 affects USP36
1 |
USP36 binds GRWD1. 1 / 1
1 |
biogrid
No evidence text available
36912080
GRSF1 affects USP36
1 |
USP36 binds GRSF1. 1 / 1
1 |
biogrid
No evidence text available
36912080
GLYR1 affects USP36
1 |
USP36 binds GLYR1. 1 / 1
1 |
biogrid
No evidence text available
36912080
GAGE2E affects USP36
1 |
GAGE2E binds USP36. 1 / 1
1 |
biogrid
No evidence text available
33961781
Fbw7α affects USP36
| 1
USP36 binds Fbw7α. 1 / 1
| 1
sparser
"Notably, USP36 interacts with the nucleolar Fbw7γ but not the nucleoplasmic Fbw7α."
31832515
FCF1 affects USP36
1 |
USP36 binds FCF1. 1 / 1
1 |
biogrid
No evidence text available
36912080
EXOSC9 affects USP36
1 |
USP36 binds EXOSC9. 1 / 1
1 |
biogrid
No evidence text available
36912080
EMG1 affects USP36
1 |
USP36 binds EMG1. 1 / 1
1 |
biogrid
No evidence text available
36912080
ELOA affects USP36
1 |
USP36 binds ELOA. 1 / 1
1 |
biogrid
No evidence text available
36912080
EIF5B affects USP36
1 |
USP36 binds EIF5B. 1 / 1
1 |
biogrid
No evidence text available
36912080
EEF2 affects USP36
1 |
USP36 binds EEF2. 1 / 1
1 |
biogrid
No evidence text available
36912080
EED affects USP36
1 |
EED binds USP36. 1 / 1
1 |
biogrid
No evidence text available
37689310
EBNA1BP2 affects USP36
1 |
USP36 binds EBNA1BP2. 1 / 1
1 |
biogrid
No evidence text available
36912080
DPM1 affects USP36
1 |
USP36 binds DPM1. 1 / 1
1 |
biogrid
No evidence text available
36912080
DNTTIP2 affects USP36
1 |
USP36 binds DNTTIP2. 1 / 1
1 |
biogrid
No evidence text available
36912080
DNAJA2 affects USP36
1 |
USP36 binds DNAJA2. 1 / 1
1 |
biogrid
No evidence text available
36912080
DNAJA1 affects USP36
1 |
USP36 binds DNAJA1. 1 / 1
1 |
biogrid
No evidence text available
36912080
DIMT1 affects USP36
1 |
USP36 binds DIMT1. 1 / 1
1 |
biogrid
No evidence text available
36912080
DHX8 affects USP36
1 |
USP36 binds DHX8. 1 / 1
1 |
biogrid
No evidence text available
36912080
DDX54 affects USP36
1 |
USP36 binds DDX54. 1 / 1
1 |
biogrid
No evidence text available
36912080
DDX52 affects USP36
1 |
USP36 binds DDX52. 1 / 1
1 |
biogrid
No evidence text available
36912080
DDX50 affects USP36
1 |
USP36 binds DDX50. 1 / 1
1 |
biogrid
No evidence text available
36912080
DDX49 affects USP36
1 |
USP36 binds DDX49. 1 / 1
1 |
biogrid
No evidence text available
36912080
DDX3X affects USP36
1 |
USP36 binds DDX3X. 1 / 1
1 |
biogrid
No evidence text available
36912080
DDX28 affects USP36
1 |
USP36 binds DDX28. 1 / 1
1 |
biogrid
No evidence text available
36912080
DDX27 affects USP36
1 |
USP36 binds DDX27. 1 / 1
1 |
biogrid
No evidence text available
36912080
DDX24 affects USP36
1 |
USP36 binds DDX24. 1 / 1
1 |
biogrid
No evidence text available
36912080
DDX21 affects USP36
1 |
USP36 binds DDX21. 1 / 1
1 |
biogrid
No evidence text available
36912080
DARS1 affects USP36
1 |
USP36 binds DARS1. 1 / 1
1 |
biogrid
No evidence text available
36912080
CX-5461 affects USP36
| 1
CX-5461 decreases the amount of USP36. 1 / 1
| 1
reach
"Interestingly, both Act D treatment and CX-5461 treatment significantly reduced the levels of USP36 in HeLa, H1299 (Figure 7E, F; Supplementary Figure S7B) and U2OS cells (Supplementary Figure S7C), whereas the levels of EXOSC10 and the examined core exosome subunit EXOSC4 were not changed by the Act D or CX-5461 treatment (Figure 7E, F; Supplementary Figure S7B), indicating that the attenuated EXOSC10 SUMOylation following ribosomal stress is associated with the reduction of USP36 protein."
36912080
CTNNB1 affects USP36
1 |
USP36 binds CTNNB1. 1 / 1
1 |
biogrid
No evidence text available
30323974
CRISP3 affects USP36
1 |
USP36 binds CRISP3. 1 / 1
1 |
biogrid
No evidence text available
36912080
COX8A affects USP36
1 |
COX8A binds USP36. 1 / 1
1 |
biogrid
No evidence text available
34079125
CORO1C affects USP36
1 |
USP36 binds CORO1C. 1 / 1
1 |
biogrid
No evidence text available
36912080
CORO1A affects USP36
1 |
USP36 binds CORO1A. 1 / 1
1 |
biogrid
No evidence text available
36912080
COIL affects USP36
1 |
USP36 binds COIL. 1 / 1
1 |
biogrid
No evidence text available
36912080
CMAS affects USP36
1 |
USP36 binds CMAS. 1 / 1
1 |
biogrid
No evidence text available
36912080
CFAP141 affects USP36
1 |
CFAP141 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
33961781
CENPA affects USP36
1 |
CENPA binds USP36. 1 / 1
1 |
biogrid
No evidence text available
34079125
CDK13 affects USP36
1 |
USP36 binds CDK13. 1 / 1
1 |
biogrid
No evidence text available
36912080
CDC14B affects USP36
1 |
CDC14B binds USP36. 1 / 1
1 |
biogrid
No evidence text available
27880917
CCT4 affects USP36
1 |
USP36 binds CCT4. 1 / 1
1 |
biogrid
No evidence text available
36912080
CCT3 affects USP36
1 |
USP36 binds CCT3. 1 / 1
1 |
biogrid
No evidence text available
36912080
CCT2 affects USP36
1 |
USP36 binds CCT2. 1 / 1
1 |
biogrid
No evidence text available
36912080
CCDC88A affects USP36
1 |
USP36 binds CCDC88A. 1 / 1
1 |
biogrid
No evidence text available
36912080
CCDC137 affects USP36
1 |
USP36 binds CCDC137. 1 / 1
1 |
biogrid
No evidence text available
36912080
CAMP affects USP36
1 |
USP36 binds CAMP. 1 / 1
1 |
biogrid
No evidence text available
36912080
CAD affects USP36
1 |
USP36 binds CAD. 1 / 1
1 |
biogrid
No evidence text available
36912080
C7orf50 affects USP36
1 |
USP36 binds C7orf50. 1 / 1
1 |
biogrid
No evidence text available
36912080
BYSL affects USP36
1 |
USP36 binds BYSL. 1 / 1
1 |
biogrid
No evidence text available
36912080
BIRC2 affects USP36
| 1
BIRC2 binds USP36. 1 / 1
| 1
sparser
"Structural determinants of USP36–cIAP1 and USP36–survivin interactions."
38876304
BCL2L1 affects USP36
| 1
BCL2L1 binds USP36. 1 / 1
| 1
sparser
"Finally, we determined the association of USP36 with Bcl-xL, p65, Mcl-1, and XIAP via coimmunoprecipitation in HEK-293 cells and observed no interactions ( xref , E – G )."
38876304
ATP5F1A affects USP36
1 |
USP36 binds ATP5F1A. 1 / 1
1 |
biogrid
No evidence text available
36912080
ATP2A2 affects USP36
1 |
USP36 binds ATP2A2. 1 / 1
1 |
biogrid
No evidence text available
36912080
ATG5 affects USP36
| 1
ATG5 activates mutated USP36. 1 / 1
| 1
reach
"However, the inability of Atg5 knockdown to suppress the USP36 mutant phenotype, as well as the accumulation of both GFP-Atg8a and p62 in USP36 mutant cells, suggests a defect in autophagic flux rather than a defect in the formation of autophagosomes."
23873149
ATAD3B affects USP36
1 |
USP36 binds ATAD3B. 1 / 1
1 |
biogrid
No evidence text available
36912080
ANKRD52 affects USP36
1 |
USP36 binds ANKRD52. 1 / 1
1 |
biogrid
No evidence text available
19615732
ALYREF affects USP36
1 |
USP36 binds ALYREF. 1 / 1
1 |
biogrid
No evidence text available
36912080
AKAP8L affects USP36
1 |
USP36 binds AKAP8L. 1 / 1
1 |
biogrid
No evidence text available
36912080
AIFM1 affects USP36
1 |
USP36 binds AIFM1. 1 / 1
1 |
biogrid
No evidence text available
36912080
AIF1 affects USP36
1 |
AIF1 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
33961781
ADARB1 affects USP36
1 |
ADARB1 binds USP36. 1 / 1
1 |
biogrid
No evidence text available
32433965
ABT1 affects USP36
1 |
USP36 binds ABT1. 1 / 1
1 |
biogrid
No evidence text available
36912080
ABCF1 affects USP36
1 |
USP36 binds ABCF1. 1 / 1
1 |
biogrid
No evidence text available
36912080
1-phenylpropan-2-amine decreases the amount of USP36. 1 / 1
1 |
ctd
No evidence text available
30779732