IndraLab

Statements

ACVRL1 increases the amount of USP36. 4 / 4
| 4
reach
"Indeed, HHT and several ribotoxic stress inducers, including anisomycin, puromycin, and blasticidin, activated JNK signaling in the upregulation of USP36 and Snail1 protein expression (Fig. 2c, d)."
37833415
reach
"Importantly, while a selective p38 inhibitor, SB203580, failed to block the HHT-induced upregulation of USP36 and Snail1, inhibition of JNK by SP600125 completely inhibited HHT-induced upregulation of the mRNA and protein expression of USP36 (Supplementary Fig. S5b–d)."
37833415
reach
"Importantly, KRIBB11 also markedly inhibited HHT-mediated upregulation of USP36 and Snail1 expression (Supplementary Fig. S6h)."
37833415
reach
"In keeping with our finding that JNK signaling upregulates USP36 expression, a combination of HHT with SP600125, a selective inhibitor of JNK, synergistically induced apoptosis, which could be largely rescued by ectopic expression of USP36 (Fig. 6q and Supplementary Fig. S7h)."
37833415