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USP36 deubiquitinates MYC. 13 / 14
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"The deubiquitinating enzyme USP28 can stabilize c-MYC by interacting with FBW7α [31], whereas USP36 deubiquitinates and stabilizes c-MYC by interacting with FBW7γ, but not with FBW7α [32]."
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"USP36 was found to protect renal function by deubiquitinating SOD2 and c-Myc, attenuating oxidative damage, and promoting cell proliferation25."
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"Recent evidence has revealed that c-Myc can be deubiquitylated and regulated by USP28, USP36 and USP37."
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"USP36 plays a direct role in MYC stabilization by interacting with and deubiquitinating MYC."
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"More importantly, in vivo assays further indicated that CBF could not only effectively inhibit colon tumor growth and metastasis but also significantly improve Oxa efficacy in colon tumors, which supported the promising potential of CBF as an emerging therapeutic for colon cancer.In summary, our research demonstrated that USP36 promotes the aggressiveness, chemoresistance, and metastasis of colon cancer by deubiquitinating and stabilizing c-Myc, and uncovered a potential USP36 inhibitor, CBF, in the treatment of colon cancer."
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"The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc."
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"45 USP36 deubiquitinates and stabilizes c-Myc through interactions with FBW7gamma in the nucleolus."
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"USP36 interacts with and deubiquitinates c-Myc in cells and in vitro, leading to the stabilization of c-Myc."
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"For example, as demonstrated by Sun and colleagues, USP36 could interact with and deubiquitinate c-Myc in nuclear, thus enhancing c-Myc signaling and regulating cell proliferation [ 10 ]."
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"Interestingly, OST-01 significantly inhibited USP36, a nucleolar protein deubiquitinase [10, 11], which lead to ubiquitination and degradation of c-Myc, NPM1, and nucleostemin (Fig. 1D and H)."
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"44 Sun found that USP36 deubiquitinates c‐Myc in the nucleolus and acts downstream of c‐Myc to promote BC proliferation."
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"Besides, USP36 can interact with c-Myc and FBW7γ, then deubiquitinating c-Myc and counteracting the degradation mediated by FBW7γ ( Sun et al., 2015 )."
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"A recent published data indicated that USP36 could interact with and deubiquitinate c-Myc, thereby suppressing c-Myc degradation and promoting c-Myc signaling [ 10 ], and such mechanisms might be invo[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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