IndraLab

Statements

USP36 activates MYC. 7 / 8
| 7
reach
"Despite this, USP36 could effectively inhibit MYC degradation initiated by both Fbw7g and Fbw7α, thereby indicating that USP36 governs the final stage of Fbw7-mediated MYC degradation within the nucleolus, while cooperating with USP28 in the nucleoplasm."
38785979
reach
"Knockdown of either Usp28 or Usp36 downregulates Myc and suppresses cancer cell proliferation in cell culture."
26459133
reach
"Mechanically, USP36 enhances c-Myc protein stabilization in HCT116 cells via deubiquitination."
38517383
reach
"XREF_BIBR - XREF_BIBR Moreover, the USP37 and USP36 can promote tumorigenesis by stabilizing c-Myc."
32140262
reach
"In contrast, knockdown of hUTP14a results in increased c-Myc ubiquitination ( Fig. 3 C), demonstrating that hUTP14a stabilizes c-Myc by inhibiting ubiquitination of c-Myc.As USP36 stabilizes c-Myc in [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30343112
reach
"USP36 modulates the activity of the Hippo/YAP, PRL1/Snail2, c-Myc/SOD2, CEP63/YAP1, Fbw7g/USP36/c-Myc, ERK/AKT ALR (augmentation of liver regeneration)/MDM2, and USP36/PARP1 pathways through interaction with specific components and exertion of deubiquitinating effects (Figure 2)."
38785979
reach
"This was verified by the Ub-AMC hydrolysis assay, which showed that CBF inhibits the enzymatic activity of USP36 with an IC50 at 2.75 μM. Notably, the stabilization of c-Myc promoted by USP36 overexpression in HCT116 cells was blocked after CBF intervention.Finally, we further explored the potential of CBF against colon cancer."
38517383