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USP36 activates ERK. 4 / 4
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"Furthermore, we demonstrate that USP36 promotes the ERK and Akt signaling pathways."

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"USP36 modulates the activity of the Hippo/YAP, PRL1/Snail2, c-Myc/SOD2, CEP63/YAP1, Fbw7g/USP36/c-Myc, ERK/AKT ALR (augmentation of liver regeneration)/MDM2, and USP36/PARP1 pathways through interaction with specific components and exertion of deubiquitinating effects (Figure 2)."

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"The Ubiquitin Specific Peptidase USP36 has been shown to interact with FBW7 to regulate MYC stability and enhance ERK and AKT signaling pathways."

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"In summary, these findings indicate that USP36 functions as a deubiquitinase to modulate PME-1 and promote the ERK and AKT signaling pathways (Figure 2E)."