IndraLab

Statements

MYCN binds USP36. 10 / 11
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reach
"Consistent with the endogenous MYCN and USP36 interaction data, ectopically expressed Halo-USP36 was immunoprecipitated with the endogenous MYCN in HeLa cells, further confirming the interaction between MYCN and USP36 (XREF_FIG, right panel)."
34056606
reach
"Considering that the ubiquitin specific protease USP36 enhances the stability of target proteins through the removal of ubiquitin moieties, we thought USP36 interaction with MYCN could be involved in the regulation of MYCN stability via ubiquitin mediated proteasomal degradation."
34056606
sparser
"USP36 Interacts With MYCN and Regulates Its Stability by Deubiquitination."
34056606
sparser
"To further investigate the interaction between USP36 and MYCN, we performed a co-immunoprecipitation (Co-IP) of MYCN to verify its association with USP36 in SK-N-BE(2) and IMR-32 cell lines."
34056606
sparser
"We found that endogenous MYCN interacts with USP36 in both of the cells lines ( xref , left and middle panels)."
34056606
sparser
"Consistent with the endogenous MYCN and USP36 interaction data, ectopically expressed Halo-USP36 was immunoprecipitated with the endogenous MYCN in HeLa cells, further confirming the interaction between MYCN and USP36 ( xref , right panel)."
34056606
sparser
"Considering that the ubiquitin-specific protease USP36 enhances the stability of target proteins through the removal of ubiquitin moieties, we thought USP36 interaction with MYCN could be involved in the regulation of MYCN stability via ubiquitin mediated proteasomal degradation."
34056606
reach
"To further investigate the interaction between USP36 and MYCN, we performed a co-immunoprecipitation (Co-IP) of MYCN to verify its association with USP36 in SK-N-BE (2) and IMR-32 cell lines."
34056606
reach
"We found that endogenous MYCN interacts with USP36 in both of the cells lines (XREF_FIG, left and middle panels)."
34056606
reach
"These results indicate that USP36 interacts with and deubiquitinates MYCN, thereby promoting the stability of MYCN."
34056606