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USP36 activates SNAI1. 4 / 4
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"Silencing of USP36 markedly reduced Snail1 protein half-life (Fig. 3c)."
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"Notably, while Snail1 protein was more stable than Snail1 , ectopic expression of USP36 significantly upregulated Snail1 protein half-life, but not Snail1 (Fig. 3k)."
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"Importantly, while a selective p38 inhibitor, SB203580, failed to block the HHT-induced upregulation of USP36 and Snail1, inhibition of JNK by SP600125 completely inhibited HHT-induced upregulation of the mRNA and protein expression of USP36 (Supplementary Fig. S5b–d)."
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"Conversely, the knockdown of USP36 led to the downregulation of Snail1 (Supplementary Fig. S1d), which was completely rescued by the restoration of USP36, but not USP36 (Fig. 2f)."
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