IndraLab

Statements

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"Peng et al. observed that the binding of miR-98-5p to vascular cell adhesion molecule 1 (VCAM1) inhibited LDL-induced HUVEC injury, while circ-USP36 overexpression can up-regulate VCAM1 expression by sponging miR-98-5p to promote HUVEC apoptosis [ xref ]."
40098005
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"Furthermore, for the circ_0068087, with similar targeted ROBO1 expression in circ-USP36, it not only aggravates hyperglycemia-induced dysfunction and inflammation of ECs with a sponge of miR-197 in diabetes but also alleviated oxLDL-induced dysfunction in HUVECs partly accompanied by reducing and upregulating miR-186-5p ( xref )."
35722128
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"Ox-LDL promoted the apoptosis and inflammation but suppressed the viability of HUVEC cells through upregulating circ-USP36, thus elevating the expression of VCAM1 via miR-98-5p."
33249762
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"Furthermore, circ-0068087 xref and circ-USP36 xref mediate ox-LDL-induced endothelial cell dysfunction, whereas circ-GNAQ plays an inhibiting impact on endothelial cell senescence xref ."
36171087
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"The circ_0003204 (also called circ-USP36) has been demonstrated to serve as the sponge of several miRNAs and regulated the endothelial injury through different molecules recently."
35722128
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"In the endothelial injury model induced by oxLDL, the levels of circ-USP36 usually increased."
35722128
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"The levels of vascular cell adhesion molecule 1 (VCAM1) and roundabout guidance receptor 1(ROBO1) was also upregulated with the miR-98-5p and miR-20a-5p downregulated and sponged by circ-USP36 in oxLDL-induced injuries, which could both accelerate the endothelial cell injury ( xref , xref )."
35722128
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"However, differently, through absorbing the miR-637 to enhance WNT4, the circ-USP36 had been reported to attenuate the EC proliferation and migration in the oxLDL-induced injury ( xref )."
35722128
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"This study aimed to uncover the function and mechanism of circ-ubiquitin specific peptidase 36 (USP36) in endothelial cells treated with oxidized low-density lipoprotein (ox-LDL)."
33249762
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"Due to the multiple targeted pathways, the epigenetic regulation network of circ-USP36 should be further discussed."
35722128
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"The levels of circ-USP36, microRNA-98-5p (miR-98-5p) and vascular cell adhesion molecule 1 (VCAM1) were examined by a quantitative real-time polymerase chain reaction (qRT-PCR)."
33249762
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"The targets of circ-USP36 and miR-98-5p were searched using starBase website, and dual-luciferase reporter assay and RNA immunoprecipitation (RIP) assay were applied to validate the above predictions."
33249762
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"Ox-LDL exposure induced the upregulation of circ-USP36 in HUVEC cells."
33249762
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"Circ-USP36 accelerated ox-LDL-induced apoptosis, inflammatory and viability inhibition of HUVEC cells."
33249762
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"MiR-98-5p was a direct downstream gene of circ-USP36."
33249762
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"Circ-USP36 promoted the injury of ox-LDL-induced HUVEC cells through targeting miR-98-5p."
33249762
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"Beyond these previously mentioned findings, one study revealed that the overexpression of circ-USP36 in ox-LDL-induced ECs exacerbated endothelial injury by sponging miR-637 and enhancing wingless type MMTV integration site family member 4 (WNT4) expression, thereby inhibiting EC proliferation and migration [ xref ]."
40098005
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"Additionally, circ-USP36 was found to be elevated in serum samples of atherosclerotic patients and to promote the apoptosis and inflammation of HUVSMCs and HUVECs activated by ox-LDL ( xref )."
35445015
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"Moreover, circ-USP36 up-regulation could increase ox-LDL-induced HUVEC inflammation by enhancing the expression of VCAM1 through sponging miR-98-5p [ xref ]."
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