IndraLab

Statements

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"These data suggest that USP36 knockdown activated extrinsic and intrinsic apoptosis."
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"PI/Annexin V double staining coupled with FACS analysis showed that USP36 depletion enhanced cell apoptosis, which could be partially reversed by further YAP overexpression in KYSE150 cells (Fig. 4L), this conclusion was observed by the western blot of caspase-3(cleaved), which showed that YAP overexpression noticeably decreased caspase-3(cleaved) protein levels (Fig. S3J)."
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"USP36 inhibits apoptosis via the stabilization of survivin and cIAP1."
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"To determine whether USP36 inhibited apoptosis, transient transfection experiments were performed in HCT 116 cells using overexpression of Bax or Fas plasmids as stimuli for inducing intrinsic and extrinsic apoptosis, respectively."
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"Overexpression of USP36 promoted NSCLC cell proliferation and inhibited NSCLC cell apoptosis."
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"Silencing USP36 in cardiac cells mitigated Dox-induced cardiomyocyte apoptosis and cardiac dysfunction."
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"We showed that the knockdown of USP36 induces intrinsic and extrinsic apoptosis."
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