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USP36 sumoylates GNL3. 2 / 2

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"We found that USP36 markedly promoted GNL3 SUMOylation, while PIAS1, but not other PIAS family members, slightly promoted GNL3 SUMOylation ( xref and xref ), suggesting that USP36 is a major GNL3 SUMO ligase."

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"Thus, USP36 may SUMOylate GNL3 in the nucleolus, thereby facilitating its interaction with BLM complex and promoting its shuttling to nuclear chromatin to execute HR function upon DSBs."

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USP36 sumoylates GNL3. 2 / 2

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