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USP36 increases the amount of EZH2. 1 / 1

1 |

"We observed a MELK-mediated increase of EZH2 S220 phosphorylation along with a concomitant loss of EZH2 K222 ubiquitination, suggesting a phosphorylation-dependent regulation of EZH2 ubiquitination. Furthermore, we identify USP36 as the deubiquitinating enzyme that deubiquitinates EZH2 at K222."

31434700

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IndraLab

Statements

USP36 increases the amount of EZH2. 1 / 1

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