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JNK increases the amount of USP36. 4 / 4
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"Importantly, while a selective p38 inhibitor, SB203580, failed to block the HHT-induced upregulation of USP36 and Snail1, inhibition of JNK by SP600125 completely inhibited HHT-induced upregulation of the mRNA and protein expression of USP36 (Supplementary Fig. S5b–d)."
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"As shown in Fig. 7a, b and Supplementary Fig. S8a, b, again, HHT effectively activated JNK, leading to upregulated expression of nucleolar USP36 and Snail1, accompanied by little apoptosis in triple-negative breast cancer SUM159, HCC1806, or Hs 578T cells."
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"In keeping with our finding that JNK signaling upregulates USP36 expression, a combination of HHT with SP600125, a selective inhibitor of JNK, synergistically induced apoptosis, which could be largely rescued by ectopic expression of USP36 (Fig. 6q and Supplementary Fig. S7h)."
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"By contrast, rapamycin, an mTOR inhibitor to inhibit protein synthesis, failed to either activate JNK or to upregulate USP36 and Snail1 protein expression (Fig. 2c, d), in keeping with our previous observation that rapamycin failed to promote Snail1 nucleolar accumulation (Fig. 1b, c)."
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