IndraLab

Statements

USP36 increases the amount of DGCR8. 3 / 3
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"As shown in Fig. 4A, overexpression of USP36 did not increase the levels of DGCR8 and Drosha in multiple tested cell lines."
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"Also, knockdown of USP36 by siRNA (Fig. 4B) or lentiviral-encoded shRNA (Fig. 4C) did not reduce the levels of DGCR8 and Drosha."
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"USP36-mediated SUMOylation does not affect the levels of DGCR8 and the formation of the Drosha-DGCR8 complex, but promotes the binding of DGCR8 to pri-miRNAs."
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