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USP36 deubiquitinates NPM1. 3 / 4
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"It was shown that NPM1 is deubiquitinated by USP36 (ubiquitin specific peptidase 36) in the nucleolus stabilizing NPM1 [52], which is in turn required for USP36 accumulation [53]."
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"Interestingly, OST-01 significantly inhibited USP36, a nucleolar protein deubiquitinase [10, 11], which lead to ubiquitination and degradation of c-Myc, NPM1, and nucleostemin (Fig. 1D and H)."
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"We also tested whether a nucleolar deubiquitinase USP36, which deubiquitinates NPM XREF_BIBR, affects the MG132 caused NPM nucleolar retention in the UV treated cells."
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