IndraLab

Statements

USP36 inhibits autophagy. 7 / 7
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"As the above study revealed, USP36 promoted the cell proliferation and inhibited autophagy, while inhibiting autophagy have no impact on the cell proliferation."
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"Therefore, USP36 inhibits the selective autophagy of protein aggregates at an early stage by removing the ubiquitin signal."
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"USP36 seems to antagonize different autophagy related processes in a context dependent manner."
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"A prior study revealed that silencing of USP36, one of the deubiquitinating enzymes, could trigger selective autophagy via a p62 dependent pathway."
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"On the contrary, silencing of USP36 triggered autophagy via a p62 dependent pathway."
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"The deletion of USP36 of Drosophila melanogaster results in an inhibition of larval growth and activated constitutively autophagy in an mTOR independent manner."
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"Therefore, USP36 inhibits the selective autophagy of protein aggregates at an early stage by removing the ubiquitin signal."
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