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Statements

USP36 activates PARP1. 2 / 2
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"Taken together, these results indicated USP36 deficiency alleviated Dox-induced cardiac injury and confirmed the effect of USP36 is mediated, at least in part, by regulating the PARP1 pathway."
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"USP36 modulates the activity of the Hippo/YAP, PRL1/Snail2, c-Myc/SOD2, CEP63/YAP1, Fbw7g/USP36/c-Myc, ERK/AKT ALR (augmentation of liver regeneration)/MDM2, and USP36/PARP1 pathways through interaction with specific components and exertion of deubiquitinating effects (Figure 2)."
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