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USP36 activates YAP1. 5 / 5
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"USP36 modulates the activity of the Hippo/YAP, PRL1/Snail2, c-Myc/SOD2, CEP63/YAP1, Fbw7g/USP36/c-Myc, ERK/AKT ALR (augmentation of liver regeneration)/MDM2, and USP36/PARP1 pathways through interaction with specific components and exertion of deubiquitinating effects (Figure 2)."
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"Our previous study clarified that ubiquitin-specific peptidase 36 (USP36) accelerates ESCC proliferation and metastasis through stabilizing YAP protein [13]."
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"Since USP36 modulates the Hippo/YAP axis and ESCC progression, we further investigated the potential mechanism."
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"Immunostaining indicated that both the YAP protein and USP36 protein were enriched in the nucleus, while USP36 depletion significantly reduced YAP staining signals in the nucleus (Fig. 5A), this conclusion was observed by the western blot of the distribution of YAP in nucleo-cytoplasmic extracts."
36470870
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"USP36 modulates the activity of the Hippo/YAP, PRL1/Snail2, c-Myc/SOD2, CEP63/YAP1, Fbw7g/USP36/c-Myc, ERK/AKT ALR (augmentation of liver regeneration)/MDM2, and USP36/PARP1 pathways through interaction with specific components and exertion of deubiquitinating effects (Figure 2)."
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