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CX-5461 decreases the amount of USP36. 1 / 1

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"Interestingly, both Act D treatment and CX-5461 treatment significantly reduced the levels of USP36 in HeLa, H1299 (Figure 7E, F; Supplementary Figure S7B) and U2OS cells (Supplementary Figure S7C), whereas the levels of EXOSC10 and the examined core exosome subunit EXOSC4 were not changed by the Act D or CX-5461 treatment (Figure 7E, F; Supplementary Figure S7B), indicating that the attenuated EXOSC10 SUMOylation following ribosomal stress is associated with the reduction of USP36 protein."

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CX-5461 decreases the amount of USP36. 1 / 1

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