IndraLab

Statements

USP36 activates apoptotic process. 6 / 6
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"As apoptotic tubular cell death is one of major characteristic features of AKI, we continued to explore whether USP36 play a role in ischemia induced tubular cell apoptosis."
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"The beneficial effects of silencing USP36 on inhibiting oxidative stress and apoptosis in cardiomyocytes are significant."
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"USP36 downregulation can promote intrinsic and extrinsic apoptosis."
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"Annexin V staining revealed that small interfering (si)USP36#1 and siUSP36#2 RNA transfection significantly enhanced cell apoptosis compared to the untreated group (Fig. 2, A and B), which was further confirmed via Western blot analysis of poly-ADP ribose polymerase (PARP) cleavage (Fig. 2, C and D)."
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"In keeping with our finding that JNK signaling upregulates USP36 expression, a combination of HHT with SP600125, a selective inhibitor of JNK, synergistically induced apoptosis, which could be largely rescued by ectopic expression of USP36 (Fig. 6q and Supplementary Fig. S7h)."
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"Moreover, northern blot analysis has shown that USP36 deficiency induces aberrations in rRNA synthesis and apoptosis at the preimplantation stage of development."
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