IndraLab

Statements

COPS3 binds USP36. 4 / 4
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sparser
"Anakinra Prevents SOD2 Degradation via USP36-COPS3."
34207085
sparser
"Mechanistically, anakinra appears to have prevented SOD2 degradation by interfering with the USP36-COPS3 complex rather than inducing its expression."
34207085
sparser
"The induction of SOD2 was selective, as other antioxidant enzymes did not appear to be modulated by anakinra, as occurs for other SOD2 mimetics, an effect that may be related to the ability of anakinra to interfere with the USP36-COPS3 complex, rather than engaging the Nrf2 pathway [ xref ]."
34207085
reach
"Specifically, from the results reported by He et al. [87], it appears that anakinra prevents SOD2 degradation by interfering with the USP36-COPS3 complex rather than by inducing its expression."
37507935