IndraLab

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"We also confirmed that endogenous USP36 interacts with endogenous Las1L ( xref )."

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"We showed that USP36 interacts with the rixosome components and that abrogating Las1L SUMOylation by the K565R mutation attenuated Las1L’s interaction with the pre-60S ribosome, suggesting that USP36 may regulate Las1L SUMOylation and 60S ribosome biogenesis in the context of the rixosome."