IndraLab

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USP36 increases the amount of BIRC2. 4 / 4
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"To assess whether USP36 modulates the endogenous levels of cIAP1 and survivin proteins, we performed transient transfection in HEK-293 cells."
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"Overexpression of USP36 increased the protein levels of endogenous cIAP1 and survivin in HEK-293 cells (Fig. 6A), whereas no discernible increase in the mRNA levels was observed."
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"In HCT 116 cells, the overexpression of USP36 also increased the protein levels of cIAP1 (Fig. 6D, left panels) and survivin (Fig. 6E, left panels), with a mild effect on the mRNA levels (Fig. 6, D and E, right panels)."
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"Although less efficient than siRNA treatments, USP36 knockdown reduced cIAP1 and survivin levels and induced apoptosis (Fig. 8A, lane 4)."
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