IndraLab

Statements


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"Resveratrol targets mitochondrial USP36-SOD2 to induce autophagy-ferroptosis and inhibit gastric cancer progression."

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"This study identifies the USP36-SOD2 axis as a critical driver of gastric cancer progression and reveals the therapeutic potential of resveratrol in targeting this pathway."

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"These findings underscore the USP36-SOD2 axis as a potential therapeutic target and highlight the adjunctive chemotherapeutic potential of resveratrol."

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"The study showed that anakinra promotes the binding of SOD2 to the deubiquitinase, ubiquitin specific peptidase 36 (USP36), and constitutive photomorphogenesis 9 (COP9) signalosome, thus increasing SOD2 protein longevity."

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"Further research has demonstrated that the interaction between USP36 and SOD2 is time-dependent and occurs at COP9 signalosome subunit 3 (COPS3) ( xref ; xref )."

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"As shown in xref b, USP36 associated with immunoprecipitated SOD2 at 2 h, but not at 4 h, indicating a transient interaction between the two molecules, in line with the transient increase in SOD2 levels."

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"Conversely, work in the mouse and human kidney suggests that Usp36 interacts with SOD2 in the mechanism of acute kidney injury due to ischaemia."

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