IndraLab

Statements

USP36 inhibits TP53. 7 / 7
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"Collectively, these results indicated that USP36 inhibits p53 transcriptional activity and negatively regulates p53 signaling pathway."
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"Conversely, USP36 indirectly suppresses p53 by stabilizing RBM28, a transcriptional repressor of the p53 promoter [110]."
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"RBM28 is required for USP36-mediated inhibition of p53 transcriptional activity."
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"Given the stabilizing impact of USP36 on RBM28-mediated p53 inhibition and the function of p53 in tumorigenesis, we evaluated the biological role of USP36 in CRC."
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"USP36 inhibits p53 signaling pathway by impairing p53 transcriptional activity."
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"Further, luciferase reporter assays indicated that p53 transcriptional activity was augmented by USP36 silencing in HCT 116 and RKO cells, which was restored by pifithrin-α (PFT-α, a p53-specific inhibitor) (Figs."
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"Chromatin immunoprecipitation (ChIP) assays also showed that USP36 knockdown enhanced the ability of p53 to bind to the promoters of its canonical downstream genes, such as p21 and BAX, whereas USP36 overexpression exhibited an opposite effect (Fig. 1E, F)."
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