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USP36 leads to the ubiquitination of MYC. 5 / 5
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"USP36, another DUB, also reverses c-MYC ubiquitylation in the nucleolus by interacting with FBXW7γ but not with FBXW7α [ 83 ]."
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"Interestingly, OST-01 significantly inhibited USP36, a nucleolar protein deubiquitinase [10, 11], which lead to ubiquitination and degradation of c-Myc, NPM1, and nucleostemin (Fig. 1D and H)."
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"Therefore, these data suggest that the c-Myc ubiquitination and degradation mediated by USP36 may play a role in the ischemic acute injury of renal tubular epithelial cells.Mitochondria generate more [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Accordingly, USP36 knock-down increased c-Myc and NPM1 ubiquitination (Fig. 1I)."
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"In contrast, USP36 overexpression rescued OST-01-induced c-Myc and NPM1 ubiquitination (Fig. 1J)."
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