IndraLab
Statements
USP20 is modified
42
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2
47
14
USP20 is phosphorylated.
42
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36
14
rlimsp
"As shown in Figure 5D and Supplementary Figure S4C, ATR depletion compromised USP20 phosphorylation at the SQ/TQ motifs and resulted in USP20 downregulation, suggesting that ATR is the major kinase responsible for USP20 phosphorylation and upregulation following replication stress."
sparser
"As shown in Figure xref and Supplementary Figure S4C, ATR depletion compromised USP20 phosphorylation at the SQ/TQ motifs and resulted in USP20 downregulation, suggesting that ATR is the major kinase responsible for USP20 phosphorylation and upregulation following replication stress."
USP20 is ubiquitinated.
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2
10
sparser
"Although pVHL functions as a master control for HIF-1alpha stabilization, as pVHL-E3 ligase mediates the ubiquitination of both HIF-1alpha and VDU2, the balance between the pVHL-mediated ubiquitination and VDU2-mediated deubiquitination of HIF-1alpha provides another level of control for HIF-1alpha stabilization."
USP20 is dephosphorylated.
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1
reach
"Prior studies have demonstrated that USP20 regulate the cell proliferation through the ATK-Claspin-CHK signaling pathway, and downregulation of USP20, could reduce the expression of Claspin through the ubiquitin-proteasome degradation and promote the DNA synthesis, suggesting a defect in the intra-S-phase checkpoint."
sparser
"The proteasome has both ubiquitin ligases and DUBs that associate with it (Crosas et al., 2006) , and several DUB-ligase pairs interact directly, including BRCC36-BRCA1, BAP1-BRCA1, USP4-Ro52, USP7-MDM2, USP8-GRAIL, USP20-pVHL, USP33-pVHL and USP44-APC (Kee and Huibregtse, 2007; Marfany and Denuc, 2008; Ventii and Wilkinson, 2008) ."
"In this report we show that another uncharacterized deubiquitinating enzyme, named VDU2 (pVHL-interacting deubiquitinating enzyme-2), is a substrate of pVHL"
"Although pVHL functions as a master control for HIF-1alpha stabilization, as pVHL-E3 ligase mediates the ubiquitination of both HIF-1alpha and VDU2, the balance between the pVHL-mediated ubiquitination and VDU2-mediated deubiquitination of HIF-1alpha provides another level of control for HIF-1alpha stabilization"
reach
"Although pVHL functions as a master control for HIF-1alpha stabilization, as pVHL-E3 ligase mediates the ubiquitination of both HIF-1alpha and VDU2, the balance between the pVHL mediated ubiquitination and VDU2 mediated deubiquitination of HIF-1alpha provides another level of control for HIF-1alpha stabilization."
reach
"Nevertheless, in USP20 knockdown cells, reconstitution of Claspin was able to rescue phospho-CHK1 levels and significantly suppress tumorigenesis, even if Rad17 levels was decreased, suggesting that Claspin is an important target of USP20 in mediating checkpoint activation and tumor suppression."
sparser
"The proteasome has both ubiquitin ligases and DUBs that associate with it (Crosas et al., 2006) , and several DUB-ligase pairs interact directly, including BRCC36-BRCA1, BAP1-BRCA1, USP4-Ro52, USP7-MDM2, USP8-GRAIL, USP20-pVHL, USP33-pVHL and USP44-APC (Kee and Huibregtse, 2007; Marfany and Denuc, 2008; Ventii and Wilkinson, 2008) ."
reach
"For example, USP11 negatively regulates TNFα-induced NF-κB activation associated with IκBα and attenuates IκBα degradation [34]; USP20 deubiquitinates TRAF6 and suppresses interleukin 1β (IL-1β)- and Tax-induced NF-κB activation [40]; Katrin et al. showed that USP15 regulates IκBα/NF-κB by deubiquitinylation IκBα[44]; and USP31 inhibits TNFα, CD40, TRAF2, TRAF6 and IKKβ-mediated NF-κB activation [45]."
"With purified proteins and in intact cells, our protein interaction studies showed that TRAF6/USP20 association and subsequent USP20-mediated TRAF6 deubiquitination were β-arrestin2-dependent."
reach
"For example, USP11 negatively regulates TNFalpha induced NF-kappaB activation associated with IkappaBalpha and attenuates IkappaBalpha degradation [XREF_BIBR]; USP20 deubiquitinates TRAF6 and suppresses interleukin 1beta (IL-1beta) - and Tax induced NF-kappaB activation [XREF_BIBR]; Katrin et al. showed that USP15 regulates IkappaBalpha and NF-kappaB by deubiquitinylation IkappaBalpha [XREF_BIBR]; and USP31 inhibits TNFalpha, CD40, TRAF2, TRAF6 and IKKbeta mediated NF-kappaB activation [XREF_BIBR]."
sparser
"Our above results demonstrated that (1) USP18 and USP20 correlate with limited oHSV-1 T1012G virus yields in SCC9 cells; (2) USP18 and USP20 interact with STING and alter the levels of STING proteins in SCC9 cells; and (3) altered STING accumulation regulates viral replication in SCC9 and SCC25 cells, while we need to further examine whether the DUB activity of USP18 or USP20 is crucial for the regulation of STING stabilization and oHSV-1 T1012G virus replication."
sparser
"Our above results demonstrated that (1) USP18 and USP20 correlate with limited oHSV-1 T1012G virus yields in SCC9 cells; (2) USP18 and USP20 interact with STING and alter the levels of STING proteins in SCC9 cells; and (3) altered STING accumulation regulates viral replication in SCC9 and SCC25 cells, while we need to further examine whether the DUB activity of USP18 or USP20 is crucial for the regulation of STING stabilization and oHSV-1 T1012G virus replication."
reach
"In a candidate screen of ubiquitin specific processing proteases (USPs) for modulating CHK1 activation, we revealed that inhibition of USP20 expression in 293T cells delayed HU induced CHK1 activation, whereas expression of siRNA resistant form of FLAG-USP20res in the endogenous USP20 depleted cells restored HU induced CHK1 activation kinetics."
sparser
"Our above results demonstrated that (1) USP18 and USP20 correlate with limited oHSV-1 T1012G virus yields in SCC9 cells; (2) USP18 and USP20 interact with STING and alter the levels of STING proteins in SCC9 cells; and (3) altered STING accumulation regulates viral replication in SCC9 and SCC25 cells, while we need to further examine whether the DUB activity of USP18 or USP20 is crucial for the regulation of STING stabilization and oHSV-1 T1012G virus replication."
USP20 binds NFkappaB.
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1
USP20 affects cell population proliferation
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8
USP20 inhibits cell population proliferation.
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5
USP20 activates cell population proliferation.
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3
sparser
"Our above results demonstrated that (1) USP18 and USP20 correlate with limited oHSV-1 T1012G virus yields in SCC9 cells; (2) USP18 and USP20 interact with STING and alter the levels of STING proteins in SCC9 cells; and (3) altered STING accumulation regulates viral replication in SCC9 and SCC25 cells, while we need to further examine whether the DUB activity of USP18 or USP20 is crucial for the regulation of STING stabilization and oHSV-1 T1012G virus replication."
reach
"Nevertheless, in USP20 knockdown cells, reconstitution of Claspin was able to rescue phospho-CHK1 levels and significantly suppress tumorigenesis, even if Rad17 levels was decreased, suggesting that Claspin is an important target of USP20 in mediating checkpoint activation and tumor suppression."
USP20 affects inflammatory response
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4
1
USP20 activates inflammatory response.
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3
USP20 inhibits inflammatory response.
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1
1
USP20 inhibits USP20.
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2
USP20 activates USP20.
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1
1
USP20 phosphorylates USP20.
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1
reach
"Lu et al. demonstrated the post-prandial increase in insulin and the glucose concentration stimulates mTORC1 to phosphorylate the deubiquitylase ubiquitin-specific peptidase 20 (USP20) at S132 and S134, which is recruited to the HMGCR complex and antagonizes its degradation (Lu et al., 2020)."
sparser
"Our above results demonstrated that (1) USP18 and USP20 correlate with limited oHSV-1 T1012G virus yields in SCC9 cells; (2) USP18 and USP20 interact with STING and alter the levels of STING proteins in SCC9 cells; and (3) altered STING accumulation regulates viral replication in SCC9 and SCC25 cells, while we need to further examine whether the DUB activity of USP18 or USP20 is crucial for the regulation of STING stabilization and oHSV-1 T1012G virus replication."
sparser
"Our above results demonstrated that (1) USP18 and USP20 correlate with limited oHSV-1 T1012G virus yields in SCC9 cells; (2) USP18 and USP20 interact with STING and alter the levels of STING proteins in SCC9 cells; and (3) altered STING accumulation regulates viral replication in SCC9 and SCC25 cells, while we need to further examine whether the DUB activity of USP18 or USP20 is crucial for the regulation of STING stabilization and oHSV-1 T1012G virus replication."
Pirinixic acid affects USP20
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USP20 affects Neoplasm Metastasis
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3
sparser
"For example, both β-arrestin2 xref and USP20 ( xref ) associate with IκBα; therefore, it is possible that a ternary complex of USP20, β-arrestin2 and IκBα facilitates deubiquitination of IκBα—a possibility made more plausible by the observation that β-arrestin2 and its homolog β-arrestin1 can inhibit IκBα degradation and NFκB signaling downstream of TNFR1. xref "
USP20 affects Atherosclerosis
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2
USP20 affects cell cycle
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2
USP20 inhibits cell cycle. 2 / 2
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2
reach
"As shown in XREF_FIG, the silencing of USP20 expression accelerated the G1-S cell cycle transition which is accompanied by decrease in the percentage of G1 cells (down to 54.05%) and increase in the percentage of cells in the S phase (up to 37.62%), and the tendency was also consistent with MKN45-siUSP20 cells and BGC-823-siUSP20 cells (P < 0.05; XREF_FIG and XREF_FIG)."
USP20 affects Stomach Neoplasms
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2
USP20 inhibits Stomach Neoplasms.
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1
USP20 inhibits Stomach Neoplasms. 1 / 1
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1
USP20 activates Stomach Neoplasms.
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1
USP20 activates Stomach Neoplasms. 1 / 1
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1
USP20 affects K33-
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2
eidos
"For example , USP11 negatively regulates TNFalpha-induced NF-kappaB activation associated with IkappaBalpha and attenuates IkappaBalpha degradation [ 34 ] ; USP20 deubiquitinates TRAF6 and suppresses interleukin 1beta ( IL-1beta ) - and Tax-induced NF-kappaB activation [ 40 ] ; Katrin et al. showed that USP15 regulates IkappaBalpha / NF-kappaB by deubiquitinylation IkappaBalpha [ 44 ] ; and USP31 inhibits TNFalpha , CD40 , TRAF2 , TRAF6 and IKKbeta-mediated NF-kappaB activation [ 45 ] ."
USP20 affects IKKalpha beta phosphorylation
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2
USP20 affects IFN-I
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1
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USP20 affects Carcinoma, Squamous Cell
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2
USP20 inhibits Carcinoma, Squamous Cell.
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USP20 inhibits Carcinoma, Squamous Cell. 1 / 1
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1
USP20 activates Carcinoma, Squamous Cell.
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1
USP20 activates Carcinoma, Squamous Cell. 1 / 1
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1
sparser
"For example, both β-arrestin2 xref and USP20 ( xref ) associate with IκBα; therefore, it is possible that a ternary complex of USP20, β-arrestin2 and IκBα facilitates deubiquitination of IκBα—a possibility made more plausible by the observation that β-arrestin2 and its homolog β-arrestin1 can inhibit IκBα degradation and NFκB signaling downstream of TNFR1. xref "
Ataxia Telangiectasia affects USP20
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2
Ataxia Telangiectasia phosphorylates USP20. 1 / 1
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1
rlimsp
"Upon β2AR activation, a specific isoform of the second messenger cAMP-dependent protein kinase A (PKAα) rapidly phosphorylates USP20 on serine 333 located in its unique insertion domain. This phosphorylation of USP20 correlates with a characteristic SDS-PAGE mobility shift of the protein, blocks its deubiquitinase activity, promotes its dissociation from the activated β2AR complex, and facilitates trafficking of the ubiquitinated β2AR to autophagosomes, which fuse with lysosomes to form autolysosomes where receptors are degraded."
Ataxia Telangiectasia phosphorylates USP20 on S333. 1 / 1
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3,4-methylenedioxymethamphetamine increases the amount of USP20.
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3,4-methylenedioxymethamphetamine decreases the amount of USP20.
1
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Tetrachloromethane affects USP20
1
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Sodium arsenite affects USP20
1
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Silicon dioxide affects USP20
1
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Protein kinase A-alpha affects USP20
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1
Progesterone affects USP20
1
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Potassium chromate affects USP20
1
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Phenobarbital affects USP20
1
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Methapyrilene affects USP20
1
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Methamphetamine affects USP20
1
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Lipopolysaccharide affects USP20
1
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Leflunomide affects USP20
1
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Interaction affects USP20
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1
Hydroperoxide affects USP20
1
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Hsa-miR-26b-5p affects USP20
1
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Ethoxyimino H-indeno b pyrazine-2 dicarbonitrile affects USP20
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1
eidos
"For example , 8-mercapto-N - ( ( tetrahydro-3-furanyl ) methyl ) -4 - quinoline carboxamide , LND-57444 , VLX1570 , ML323 , ( ADC-01 , ADC-03 , HBX41108 , HBX19818 , P5091 , P22077 ) , 9 - ( ethoxyimino ) -9 H-indeno ( 1,2 - b ) pyrazine-2 ,3 - dicarbonitrile , WP1130 , Mitoxantrone and GSK2643943A are able to inhibit PSMD14 , UCHL1 , UCHL5 and USP14 , USP1 , USP7 , USP8 , USP9X , USP11 and USP20 , respectively ."
Carbon nanotube affects USP20
1
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Bisphenol A affects USP20
1
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Bis(2-ethylhexyl) phthalate affects USP20
1
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Benzo[e]pyrene affects USP20
1
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Benzo[a]pyrene affects USP20
1
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All-trans-retinoic acid affects USP20
1
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Adrenergic receptor activity affects USP20
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1
WP1130 affects USP20
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1
eidos
"For example , 8-mercapto-N - ( ( tetrahydro-3-furanyl ) methyl ) -4 - quinoline carboxamide , LND-57444 , VLX1570 , ML323 , ( ADC-01 , ADC-03 , HBX41108 , HBX19818 , P5091 , P22077 ) , 9 - ( ethoxyimino ) -9 H-indeno ( 1,2 - b ) pyrazine-2 ,3 - dicarbonitrile , WP1130 , Mitoxantrone and GSK2643943A are able to inhibit PSMD14 , UCHL1 , UCHL5 and USP14 , USP1 , USP7 , USP8 , USP9X , USP11 and USP20 , respectively ."
USP33 affects ARs
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USP20 affects ubiquitinated HIF-1alpha
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1
USP20 affects type I IFNs
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1
USP20 affects stability STING
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1
USP20 affects signaling
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1
USP20 affects signaling complex composed p62 PKCzeta RIPK1
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1
USP20 affects severity cerebral ischemic stroke
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1
eidos
"Notably , suppressing PTEN with its specific inhibitor dramatically abolished the function of USP20 to ameliorate neuroinflammation and neuron death induced by OGD / R. Collectively , our results illustrated that USP20 could effectively mitigate the severity of cerebral ischemic stroke and improve behavior deficits in MCAO-operated mice , and identified the USP20 / PTEN axis as a promising therapeutic target for ischemic stroke treatment ."
USP20 affects sensitivity cells chemotherapy
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1
USP20 affects post-endocytic trafficking autophagosomes
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1
USP20 affects polyubiquitination MCL1
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1
USP20 affects pVHL-E3 ligase
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1
USP20 affects p62 protein
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1
USP20 affects neointimal hyperplasia caused carotid endothelial denudation transgenic mice model
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1
USP20 inhibits neointimal hyperplasia caused carotid endothelial denudation transgenic mice model. 1 / 1
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1
eidos
"Intriguingly , USP20 impedes TLR4-induced NF-kappaB activation by deubiquitinating TNF receptor-associated factor 6,147 whereas it inhibits IL-1R and TNF-triggered NF-kappaB activation by deubiquitinating receptor-interacting protein kinase 1.148 Consistent with the results of the in vitro experiments , USP20 decreased neointimal hyperplasia caused by carotid endothelial denudation in a transgenic mice model ."
USP20 affects ischemic stroke mice
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1
USP20 affects iodothyronine deiodinase
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1
USP20 activates iodothyronine deiodinase. 1 / 1
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1
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1
USP20 deubiquitinates hypoxia-inducible factor-1 alpha. 1 / 1
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1
USP20 affects deubiquitination beta2-ARs
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1
USP20 affects conversion MCL1
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1
USP20 affects cleaved caspase-8 caspase-3 PARP TNFalpha CHX compared control HeLa cells causing basal cleaved proteins
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1
USP20 inhibits cleaved caspase-8 caspase-3 PARP TNFalpha CHX compared control HeLa cells causing basal cleaved proteins. 1 / 1
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1
eidos
"In addition , immunoblot analysis showed that USP20 depletion increases the expression of cleaved caspase-8 , caspase-3 and PARP in the presence of TNFalpha / CHX , compared to control HeLa cells , as well as causing increased basal levels of these cleaved proteins without TNFalpha / CHX ( Figure 4D ) ."
USP20 affects cholesterol
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1
USP20 activates cholesterol. 1 / 1
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1
USP20 affects cell migration invasion breast cancer
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1
USP20 affects cell growth
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1
USP20 inhibits cell growth. 1 / 1
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1
USP20 affects cell death
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1
USP20 inhibits cell death. 1 / 1
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1
USP20 affects cell death pathways
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1
USP20 affects beta2AR
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1
USP20 affects beta2-ARs
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1
USP20 affects beta-arrestins
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1
USP20 affects beta-arrestin
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1
USP20 affects beta-andregenic receptor
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1
eidos
"Notably , suppressing PTEN with its specific inhibitor dramatically abolished the function of USP20 to ameliorate neuroinflammation and neuron death induced by OGD / R. Collectively , our results illustrated that USP20 could effectively mitigate the severity of cerebral ischemic stroke and improve behavior deficits in MCAO-operated mice , and identified the USP20 / PTEN axis as a promising therapeutic target for ischemic stroke treatment ."
USP20 affects atypical PKCzeta-RIPK1-p62 complex required NF-kappaB activation
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1
USP20 affects apoptosis induced cycloheximide TNFalpha TAK1
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1
USP20 affects antiviral responses
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1
USP20 affects adrenergic receptor activity
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1
USP20 affects activity
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1
USP20 affects activation
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1
USP20 affects activation STING pathway
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1
USP20 affects USP18-induced deubiquitination STING knockdown
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1
USP20 affects Tax-induced NF-kappaB activation
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1
eidos
"For example , USP11 negatively regulates TNFalpha-induced NF-kappaB activation associated with IkappaBalpha and attenuates IkappaBalpha degradation [ 34 ] ; USP20 deubiquitinates TRAF6 and suppresses interleukin 1beta ( IL-1beta ) - and Tax-induced NF-kappaB activation [ 40 ] ; Katrin et al. showed that USP15 regulates IkappaBalpha / NF-kappaB by deubiquitinylation IkappaBalpha [ 44 ] ; and USP31 inhibits TNFalpha , CD40 , TRAF2 , TRAF6 and IKKbeta-mediated NF-kappaB activation [ 45 ] ."
USP20 affects TNFalpha-mediated
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1
TNFalpha-mediated binds USP20. 1 / 1
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1
USP20 affects TNFalpha-induced NF-kappaB activation regarding PKCzeta
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1
USP20 affects TLR4-induced NF-kappaB
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1
eidos
"Intriguingly , USP20 impedes TLR4-induced NF-kappaB activation by deubiquitinating TNF receptor-associated factor 6,147 whereas it inhibits IL-1R and TNF-triggered NF-kappaB activation by deubiquitinating receptor-interacting protein kinase 1.148 Consistent with the results of the in vitro experiments , USP20 decreased neointimal hyperplasia caused by carotid endothelial denudation in a transgenic mice model ."
USP20 affects Signaling
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1
USP20 affects Reperfusion Injury
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1
USP20 activates Reperfusion Injury. 1 / 1
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1
USP20 affects PKCzeta-RIPK1-p62
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1
PKCzeta-RIPK1-p62 binds USP20. 1 / 1
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1
USP20 affects NF-kappaB-mediated target
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1
USP20 affects MCAO-operated mice
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1
eidos
"Notably , suppressing PTEN with its specific inhibitor dramatically abolished the function of USP20 to ameliorate neuroinflammation and neuron death induced by OGD / R. Collectively , our results illustrated that USP20 could effectively mitigate the severity of cerebral ischemic stroke and improve behavior deficits in MCAO-operated mice , and identified the USP20 / PTEN axis as a promising therapeutic target for ischemic stroke treatment ."
USP20 affects MCAO-induced ischemic brain injury
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USP20 affects K48-linked deubiquitination STING
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1
USP20 affects K48-
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1
USP20 affects Interferon
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1
USP20 inhibits Interferon. 1 / 1
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1
USP20 affects Infections
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1
USP20 inhibits Infections. 1 / 1
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1
USP20 affects IFNs proinflammatory cytokines
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1
USP20 affects Hyperplasia
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1
USP20 activates Hyperplasia. 1 / 1
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1
USP20 affects HIF-1alpha target
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1
USP20 affects HIF-1alpha [
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USP20 affects HIF)-1alpha
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1
USP20 affects Genomic Instability
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USP20 activates Genomic Instability. 1 / 1
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1
USP20 affects Deubiquitinase
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1
USP20 activates Deubiquitinase. 1 / 1
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1
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1
USP20 phosphorylates DNA damage response, detection of DNA damage. 1 / 1
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1
USP20 affects Cellular Antiviral Responses
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1
USP20 affects Cell Survival
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1
USP20 activates Cell Survival. 1 / 1
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1
USP20 affects CLAPSIN
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1
USP20 affects Breast Neoplasms
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1
USP20 activates Breast Neoplasms. 1 / 1
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1
reach
"Lu et al. demonstrated the post-prandial increase in insulin and the glucose concentration stimulates mTORC1 to phosphorylate the deubiquitylase ubiquitin-specific peptidase 20 (USP20) at S132 and S134, which is recruited to the HMGCR complex and antagonizes its degradation (Lu et al., 2020)."
USP20 affects ATR-Chk1 [
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1
USP20 affects ATR-CLASPIN-CHK1
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1
USP20 affects ARs
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1
TNFalpha-mediated affects USP20
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1
TNFalpha-mediated binds USP20. 1 / 1
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1
TINCR affects USP20
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1
PKCzeta-RIPK1-p62 affects USP20
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1
PKCzeta-RIPK1-p62 binds USP20. 1 / 1
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1
P22077 affects USP20
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1
Niclosamide affects USP20
1
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NFkappaB affects USP20
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1
HIF-1alpha [ affects USP20
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1
GSK2643943A affects USP20
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1
eidos
"For example , 8-mercapto-N - ( ( tetrahydro-3-furanyl ) methyl ) -4 - quinoline carboxamide , LND-57444 , VLX1570 , ML323 , ( ADC-01 , ADC-03 , HBX41108 , HBX19818 , P5091 , P22077 ) , 9 - ( ethoxyimino ) -9 H-indeno ( 1,2 - b ) pyrazine-2 ,3 - dicarbonitrile , WP1130 , Mitoxantrone and GSK2643943A are able to inhibit PSMD14 , UCHL1 , UCHL5 and USP14 , USP1 , USP7 , USP8 , USP9X , USP11 and USP20 , respectively ."
E3_Ub_ligase affects USP20
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1
E3_Ub_ligase ubiquitinates USP20. 1 / 1
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1
CLAPSIN affects USP20
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1
Arrestins affects USP20
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1
ARs affects USP33
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1
2-hydroxypropanoic acid affects USP20
1
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17alpha-ethynylestradiol affects USP20
1
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(R)-noradrenaline affects USP20
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1
(R)-noradrenaline activates USP20. 1 / 1
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1
(+)-JQ1 compound affects USP20
1
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