IndraLab

Statements

USP20 inhibits inflammatory response. 6 / 6
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"Thus, USP20 inhibits SMC inflammation in response to the atherogenic cytokine IL-1β, as it does to the atherogenic activation of TLR4. xref "
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"Notably, mechanistic analysis indicated that USP20 directly interacted with PTEN, thereafter reducing inflammatory response in microglial cells and mitigating neuronal death in cortical neurons upon O[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Smooth muscle cell (SMC) USP20 activity suppresses vascular inflammation, as demonstrated in the context of carotid endothelial denudation in nonatherogenic mice (3) and atherosclerosis in Ldlr mice (4)."
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"Preventing USP20 phosphorylation on Ser334 attenuates vascular inflammation."
37311534
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"USP20 (Ubiquitin Specific Protease 20) Inhibits TNF (Tumor Necrosis Factor)-Triggered Smooth Muscle Cell Inflammation and Attenuates Atherosclerosis."
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"In vivo, specific overexpression of USP20 in VSMCs significantly reduces vascular inflammation and ameliorates atherosclerosis."
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