IndraLab

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USP20 deubiquitinates HIF1A. 5 / 5
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"USP20 stabilizes HIF-1α by abolishing von Hippel-Lindau protein (pVHL)-E3 ligase complex-mediated HIF-1α degradation."
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"VDU2 can specifically deubiquitinate and stabilize HIF-1alpha and, therefore, increase expression of HIF-1alpha targeted genes, such as vascular endothelial growth factor (VEGF)."
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"In addition, VDU2, but not VDU1, is able to interact with and deubiquitinate HIF1alpha, and rescue it from proteasome mediated degradation."
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"In addition, it was shown that VDU2 but not VDU1 can deubiquitylate HIF-1alpha and increase it 's half-life."
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"One of them, USP-20, deubiquitinates HIF-1alpha and therefore tends to stabilize it [46] by preventing its proteasomal degradation."
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