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MTORC1 phosphorylates USP20. 4 / 4
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"USP20 stabilizes HMG-CoA reductase (HMGCR), the rate-limiting enzyme in the cholesterol biosynthetic pathway, and USP20 was phosphorylated by mTORC1 at S132 and S134 xref ."
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"It has been reported that mTORC1 promotes cholesterol synthesis by phosphorylating USP20 to protect the HMGCR complex from degradation [ 30 ] and trigger the production of mature SREBP2 [ 33 ] to posi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"After insulin stimulation, USP20 is phosphorylated by the mammalian target of rapamycin complex 1 (mTORC1) and then stabilizes the HMGCR complex on the endoplasmic reticulum via interaction with Gp78 [50]."
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"They found that elevated postprandial blood glucose and insulin levels activate mTORC1 (mechanistic target of rapamycin complex 1), which stabilizes HMGCR (3-hydroxy-methylglutaryl coenzyme A reductase), phosphorylates USP20 (ubiquitin-specific peptidase 20), and upregulates cholesterol biosynthesis."
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