IndraLab

Statements

IRAK1 phosphorylates USP20 on S333. 10 / 10
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"We hypothesized that in the context of IL-1β signaling, perhaps other serine/threonine kinases, including IRAK1 might also phosphorylate USP20 Ser334."
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"Thus, IRAK1 can phosphorylate USP20 on Ser333 (of the human USP20 sequence) in preparations of purified proteins."
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"Does IRAK1 phosphorylate mouse USP20 on Ser334 in intact SMCs?"
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"Hence, we infer that IRAK1 knockdown is specific in SMCs, and SMC IRAK1 phosphorylates USP20 Ser334."
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"Therefore, IRAK1 could not only promote TRAF6 activation but also prevent TRAF6 inactivation (deubiquitination)—if, indeed, IRAK1 phosphorylates USP20 on Ser334 (and thereby reduces the association of USP20 with TRAF6)."
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"Thus, IRAK1 can phosphorylate USP20 on Ser333 (of the human USP20 sequence) in preparations of purified proteins.Does IRAK1 phosphorylate mouse USP20 on Ser334 in intact SMCs?"
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"Together, these results suggest that IRAK1 inhibits USP20-mediated deubiquitination of TRAF6 by phosphorylating USP20 on Ser334 and reducing USP20:TRAF6 association."
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"In preparations of purified proteins and in intact SMCs, we found that phosphorylation of USP20 on Ser334 is mediated by IRAK1."
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"Our studies revealed that USP20 Ser334 is phosphorylated by IRAK1."
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"Our studies revealed that USP20 Ser334 is phosphorylated by IRAK1."
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