IndraLab

Statements


USP20 activates CLSPN. 3 / 9
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"USP20 promotes CLASPIN stability through deubiquitination."

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"Given that HERC2 is a component of the replication complex, our data shown in this report suggest that HERC2 and USP20 coordinately modulate CLASPIN stability during S-phase and in response to replication stress."

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"These results revealed that USP20 mediated Claspin downregulation did not occur at the gene transcription level, just as the prior study reported that USP20 deubiquitinate and stabilize Claspin."