IndraLab

Statements

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"Low expression of USP20 significantly promoted cell proliferation and accelerated the transition from G1 to S phase of the cell cycle [60]."
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"Depletion of several DUBs caused either resistance or hypersensitivity to HU treatment; among them, USP20 knockdown showed most significant hypersensitivity to HU treatment, while knockdown of USP20 slightly decreased cell proliferation in untreated cells."
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"USP20 was shown to promote breast tumor metastasis, and proliferation of oral squamous carcinoma cells."
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"These finding revealed that USP20 could modulate GC cell proliferation."
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"However, these data are contradicted by recent findings showing that USP20 promotes proliferation, invasion, migration, and chemoresistance of multiple cancer cells via deubiquitylation of β-catenin [[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"67 A recent study reported that USP20 stabilizes β‐catenin and activates Wnt/β‐catenin signaling pathway, thereby promoting the migration, invasion, and proliferation of cancer cells."
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"And they also observed that USP20 overexpression markedly increased cell proliferation, migration and invasion in these cancer cell lines."
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"Basic experiments verified that USP20 overexpression promoted both the proliferation and migration of breast cancer cells."
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"Altogether, these findings and Figure 4 suggest that phosphorylation of USP20 on Ser334 augments neointimal hyperplasia primarily by increasing inflammatory signaling and associated proliferation of SMCs.To model neointimal hyperplasia in vitro (16, 17), we assessed proliferation and migration of SMCs derived from WT and USP20-S334A mice."
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"The EdU assay indicated that USP20 silencing significantly decreased the number of EdU-positive BC cells, whereas USP20 overexpression increased the proliferation rate of BC cells (Fig. 3C)."
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"We also observed that knockdown or pharmacologically inhibition of USP20 could significantly reduce the proliferation and viability of HCC cells, which was consistent with previous studies."
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