IndraLab

Statements

TINCR activates USP20. 4 / 4
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reach
"Specifically, TINCR acts as a molecular sponge for miR-199a-5p and upregulates the USP20 stability through a ceRNA regulatory mechanism, promoting the upregulation of PD-L1 protein by inhibiting its ubiquitination."
37342324
reach
"Then we extended the processing time and confirmed that IFN-γ Stimulation can indeed downregulate the expression of miR-199a-5p.This is the first study to clarify the mechanism by which TINCR upregulates USP20 and PD-L1 through the dual role of ceRNA interaction and miR-199a-5p transcription inhibition."
36725842
reach
"In the cytoplasm, TINCR sponges miR-199a-5p to increase USP20 mRNA stability."
37901333
reach
"Furthermore, in the cytoplasm, TINCR potentially acts as a molecular sponge of miR-199a-5p and upregulates the stability of USP20 mRNA through a competing endogenous RNA (ceRNA) regulatory mechanism, thus promoting PD-L1 expression by decreasing its ubiquitination level."
36725842