IndraLab

Statements

USP20 is phosphorylated on S333. 11 / 11
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"To determine whether USP20 Ser334 phosphorylation regulates pro-inflammatory signaling, we created USP20-S334A mice using CRISPR/Cas9-mediated gene editing."
37311534
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"Reversible phosphorylation of USP20 at S333 could be a critical factor that determines the rate of down-regulation of β 2 ARs via autophagosomes during catecholamine stress [ xref ]."
28137506
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"In this process, phosphorylation of USP20 at serine residue 333 is required for its activity providing an additional level of regulation [148]."
30126257
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"The association of USP20 with its substrates triggers deubiquitinase activity; this association is regulated by phosphorylation of USP20 on Ser334 (mouse) or Ser333 (human)."
37311534
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"In this process, phosphorylation of USP20 at serine residue 333 is required for its activity providing an additional level of regulation [ xref ]."
30126257
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"Recent studies have shown that β 2 AR activation triggers site-specific phosphorylation of USP20 by the cAMP-activated protein kinase A (PKA) at serine 333 of USP20 [ xref ]."
28137506
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"Our findings reveal novel mechanisms regulating IL-1β-induced pro-inflammatory signaling: by phosphorylating USP20 Ser334, IRAK1 diminishes the association of USP20 with TRAF6 and thus augments NFκB activation, SMC inflammation and neointimal hyperplasia."
37311534
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"The association of USP20 with its substrates triggers deubiquitinase activity; this association is regulated by phosphorylation of USP20 on Ser334 (mouse) or Ser333 (human)."
37311534
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"USP20 Ser333 phosphorylation was greater in SMCs of atherosclerotic segments of human arteries as compared with non-atherosclerotic segments."
37311534
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"WT carotid SMCs showed substantial phosphorylation of USP20 Ser334, and WT carotids demonstrated greater NFκB activation, VCAM-1 expression, and SMC proliferation than USP20-S334A carotids."
37311534
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"β1AR-induced phosphorylation of USP20 Ser333 by protein kinase A-α (PKAα) was required for optimal USP20-mediated regulation of β1AR lysosomal trafficking."
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