IndraLab

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USP20 activates Hyperplasia. 2 / 2
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"Our findings reveal novel mechanisms regulating IL-1beta-induced proinflammatory signaling: by phosphorylating USP20 Ser334, IRAK1 diminishes the association of USP20 with TRAF6 and thus augments NFkappaB activation, SMC inflammation, and neointimal hyperplasia."
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reach
"Altogether, these findings and Figure 4 suggest that phosphorylation of USP20 on Ser334 augments neointimal hyperplasia primarily by increasing inflammatory signaling and associated proliferation of SMCs.To model neointimal hyperplasia in vitro (16, 17), we assessed proliferation and migration of SMCs derived from WT and USP20-S334A mice."
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