IndraLab

Statements

HERC2 inhibits USP20. 5 / 5
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"HERC2 promotes USP20 degradation."
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"Taken together, these results suggested that HERC2 functions as an E3 ligase of USP20 and negatively regulates USP20 in unstressed cells."
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"In HERC2 depleted cells, USP20 and its substrates Claspin were significantly upregulated and the phosphorylation of CHK1 is more sustained, even at later time points."
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"Here we found that HERC2 antagonized USP20 function and negatively regulated the replication stress signaling pathway."
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"Mechanistically, HERC2 promotes proteasomal degradation of USP20 (a deubiquitinase that catalyses deubiquitination of K48-linked ubiquitinated substrates) and thereby facilitates proteasomal degradati[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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