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USP20 deubiquitinates TRAF6. 13 / 14
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"USP20 achieves anti-inflammatory activity in SMCs, in part, by deubiquitinating the E3 ubiquitin ligase TRAF6 (3)."
37311534
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"TRAF6 activity can be impeded by deubiquitinating enzymes like ubiquitin specific protease 20 (USP20), which can reverse TRAF6 autoubiquitination, and by association with the multifunctional adaptor protein beta-arrestin2."
26839314
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"β-arrestin2 and USP20 inhibit the ubiquitination of TRAF6 through the shared mechanism."
33741415
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"For example, Junichiro et al. demonstrated that USP21 constitutively deubiquitinates RIP1 in vitro and in vivo [XREF_BIBR]; and a previous study has reported that USP20 deubiquitinates TRAF6 and Tax in vivo [XREF_BIBR]."
24260525
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"54 Ubiquitinated beta-arrestin2 promotes NF-kappaB signaling in SMCs, whereas deubiquitinated beta-arrestin2 attenuates NF-kappaB signaling by scaffolding the deubiquitinase USP20, that in turn deubiquitinates TRAF6, which blocks the NF-kappaB signaling cascade."
28328745
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"USP20 deubiquitinates TRAF6 and β-arrestin2, and the overexpression of β-arrestin2 is more effective in linking USP20 to TRAF6."
33741415
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"Here, we report that ubiquitin specific peptidase USP20 deubiquitinates TRAF6 and Tax and suppresses interleukin 1beta (IL-1beta) - and Tax induced NF-kappaB activation."
21525354
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"For example, USP11 negatively regulates TNFalpha induced NF-kappaB activation associated with IkappaBalpha and attenuates IkappaBalpha degradation [XREF_BIBR]; USP20 deubiquitinates TRAF6 and suppresses interleukin 1beta (IL-1beta) - and Tax induced NF-kappaB activation [XREF_BIBR]; Katrin et al. showed that USP15 regulates IkappaBalpha and NF-kappaB by deubiquitinylation IkappaBalpha [XREF_BIBR]; and USP31 inhibits TNFalpha, CD40, TRAF2, TRAF6 and IKKbeta mediated NF-kappaB activation [XREF_BIBR]."
24260525
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"Together, these results suggest that IRAK1 inhibits USP20-mediated deubiquitination of TRAF6 by phosphorylating USP20 on Ser334 and reducing USP20:TRAF6 association."
37311534
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"Previous study indicated that USP20 can deubiquitinate TRAF6 and eliminate NF-κB-dependent gene expression, thereby suppressing inflammatory response during atherosclerosis development [13] ."
34953448
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"For example, USP20 deubiquitinates not only TRAF6 and β-arrestin2 to reduce TLR4-induced NFκB activation (3) but also RIPK1 to prevent TNFR-induced NFκB activation (4)."
37311534
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"USP20 has been shown to form a complex with β-arrestin 2 and TRAF6 and to promote TRAF6 deubiquitination [215]."
36834633
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"We report that two ubiquitin specific peptidases, USP20 and USP33, deubiquitinate TRAF6 and suppress IL-1beta-induced NF-kappaB activation."
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