IndraLab

Statements

USP20 binds HSPA2. 17 / 17
3 | 2 12
biogrid
No evidence text available
36636478
sparser
"These results were consistent with our findings that USP20 interacted with HSPA2 and stabilized HSPA2 via deubiquitination."
36636478
sparser
"Our study identified a new pathway involved in SG where the downregulation of USP20-HSPA2 axis improved lipid metabolism."
36636478
sparser
"The downregulation of the USP20-HSPA2 axis in diet-induced obese mice following SG improved lipid dysmetabolism, indicating that USP20-HSPA2 axis was a noninvasive therapeutic target to be investigated in the future."
36636478
sparser
"Therefore, fatty acid biosynthesis and cholesterol transport are the possible pathways by which the USP20-HSPA2 axis achieves biological functions."
36636478
reach
"These results indicated an interaction between USP20 and HSPA2, and owing to the deubiquitinating enzyme function of USP20, we tested whether USP20 induced the deubiquitination of HSPA2."
36636478
sparser
"Some limitations of this study include the necessity of in vivo experiments to verify the effect of the USP20-HSPA2 axis on lipid metabolism."
36636478
sparser
"The downstream pathway of the USP20-HSPA2 axis needs further studies for validation."
36636478
sparser
"In conclusion, our study provides evidence that the USP20-HSPA2 axis is downregulated in the SG group."
36636478
sparser
"To gain insight into the USP20-HSPA2 axis mechanism, we first examined whether there was an interaction between USP20 and HSPA2."
36636478
sparser
"It also showed that SG improves lipid metabolism by downregulating the USP20-HSPA2 axis to some degree ( xref )."
36636478
biogrid
No evidence text available
36636478
sparser
"We propose a possible mechanism demonstrated in DIO mice, involving the downregulation of the USP20-HSPA2 axis."
36636478
sparser
"These results indicated an interaction between USP20 and HSPA2, and owing to the deubiquitinating enzyme function of USP20, we tested whether USP20 induced the deubiquitination of HSPA2."
36636478
biogrid
No evidence text available
36636478
sparser
"Our results therefore demonstrated that the mechanism of the USP20-HSPA2 axis involves the stabilization of HSPA2 by USP20 via deubiquitination."
36636478
reach
"To gain insight into the USP20-HSPA2 axis mechanism, we first examined whether there was an interaction between USP20 and HSPA2."
36636478