IndraLab

Statements

USP20 binds HIF1A. 9 / 10
3 | 3 3
reach
"For example, VHL interacting deubiquitinating enzyme 2 (VDU2) interacts with HIF-1alpha and specifically deubiquitinates and stabilizes HIF-1alpha [XREF_BIBR]."
22521794
sparser
"In contrast to VDU2 which directly interacts with HIF-1α, USP28 forms a ternary complex with HIF-1α via its association with HIF-1α bound Fbw7 (Flügel et al., xref )."
26942179
sparser
"According to those findings, USP20 binds to and stabilizes HIF-1α."
31208103
reach
"Molecular and cellular experiments showed that VDU2 interacted with HIF-1alpha in order to induce the expression of HIF-1 downstream genes, such as VEGF, through the deubiquitination and stabilization of HIF-1alpha."
29285833
biogrid
No evidence text available
15776016
sparser
"However, by using in vitro pull down assays with GST-HIF-1α (amino acid 530–826) and co-immunoprecipitation experiments in COS-7 cells it was shown that only VDU2 but not VDU1 could interact with HIF-1α (Li et al., xref )."
26942179
biogrid
No evidence text available
15776016
biogrid
No evidence text available
15776016
reach
"The interaction between HIF-1alpha and VDU2 was shown using an immunoprecipitation assay."
29285833