IndraLab

Statements

USP20 inhibits NFkappaB. 7 / 7
| 1 5 1
reach
"USP18 deficiency or knockdown of USP20 resulted in enhanced K48 linked ubiquitination and accelerated degradation of STING, and impaired activation of IRF3 and NF-kappaB as well as induction of downstream genes after infection with DNA virus HSV-1 or transfection of various DNA ligands."
27801882
reach
"XREF_BIBR This study showed that USP18 or USP20 deficiency significantly inhibited HSV-I or cytosolic DNA activation of both NF-kappaB and IRF3, and type-I IFN and proinflammatory cytokine expression."
30989105
reach
"Ubiquitin-specific peptidase 20 (USP20) reduces NFkappaB activation triggered by proinflammatory stimuli, and USP20 activity attenuates atherosclerosis in mice."
37311534
reach
"Silencing USP20 in SMCs with siRNA (small interfering RNA) augmented NFkappaB activation by = ~ 50% in response to either TNF or IL-1beta (interleukin-1beta)."
30354204
reach
"XREF_BIBR USP20 inhibits NF-kappaB activation via Toll like receptor (TLR) 4, XREF_BIBR IL-1R, and the TNF XREF_BIBR inflammatory pathway in VSMCs."
33664994
eidos
"Ubiquitin-specific peptidase 20 ( USP20 ) reduces NFkappaB activation triggered by pro-inflammatory stimuli , and USP20 activity attenuates atherosclerosis in mice ."
37311534
sparser
"USPs are the most abundant DUBs, with approximately 60 proteases in humans. xref USP20 inhibits NF-κB activation via Toll-like receptor (TLR)4, xref IL-1R, and the TNF xref inflammatory pathway in VSMCs."
33664994