IndraLab

Statements

ULK1 binds USP20. 11 / 11
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sparser
"USP20 can bind, de-ubiquitinate and stabilize ULK1 at a basal level and plays an important role in autophagy initiation."
32887506
reach
"USP20 interacts with and deubiquitinates ULK1, thus protecting it from degradation."
30126257
reach
"However, the interaction between ULK1 and USP20 is weakened upon prolonged induction of autophagy (4 to 8 h), leading to a reduction of the level of ULK1 protein while its ubiquitinated form accumulates [XREF_BIBR]."
30126257
sparser
"However, the interaction between ULK1 and USP20 is weakened upon prolonged induction of autophagy (4 to 8 h), leading to a reduction of the level of ULK1 protein while its ubiquitinated form accumulates [64]."
30126257
reach
"Under prolonged starvation, the binding of USP20 to ULK1 is diminished, leading to autophagy inhibition [43]."
31630678
sparser
"Under prolonged starvation, the binding of USP20 to ULK1 is diminished, leading to autophagy inhibition [ xref ]."
31630678
reach
"At basal state, USP20 binds to and stabilizes ULK1 by removing the ubiquitin moiety, thereby interfering with the lysosomal degradation of ULK1."
29487085
sparser
"However, the interaction between ULK1 and USP20 is weakened upon prolonged induction of autophagy (4 to 8 h), leading to a reduction of the level of ULK1 protein while its ubiquitinated form accumulates [ xref ]."
30126257
sparser
"During prolonged starvation, NEDD4L catalyzes the K27 and K29 ubiquitination on ULK1 [ xref ], whereas the interaction between USP20 and ULK1 is attenuated [ xref ]."
31630678
reach
"During prolonged starvation, NEDD4L catalyzes the K27 and K29 ubiquitination on ULK1 [58], whereas the interaction between USP20 and ULK1 is attenuated [43]."
31630678
sparser
"In prolonged starvation, the interaction between USP20 and ULK1 reduces to terminate autophagy [ xref ]."
| PMC