IndraLab

Statements

ULK1 binds USP20. 25 / 25
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"Notably, USP20 upregulation correlates with enhanced stability of the autophagy initiating kinase ULK1, highlighting the role of HERC2 as an autophagy regulator factor through the USP20-ULK1 axis."
38570483
sparser
"Our investigation unveils a novel role for HERC2 as an autophagy regulator factor through the USP20-ULK1 axis, providing new insights into the pathomolecular basis of HERC2-related disorder and Angelman syndrome."
38570483
sparser
"HERC2 regulates protein levels of the USP20-ULK1 axis."
38570483
sparser
"However, to date, no direct connection between HERC2, the USP20-ULK1 axis, and the regulation of autophagy has been reported."
38570483
sparser
"However, the interaction between ULK1 and USP20 is weakened upon prolonged induction of autophagy (4 to 8 h), leading to a reduction of the level of ULK1 protein while its ubiquitinated form accumulates [ xref ]."
30126257
biogrid
No evidence text available
29487085
biogrid
No evidence text available
29487085
biogrid
No evidence text available
29487085
biogrid
No evidence text available
29487085
reach
"At basal state, USP20 binds to and stabilizes ULK1 by removing the ubiquitin moiety, thereby interfering with the lysosomal degradation of ULK1."
29487085
sparser
"Similarly, USP20 interacts with ULK1 at basal levels, controlling the initiation of autophagy by maintaining the basal expression level of ULK1 (Kim et al. xref )."
41387651
reach
"Under prolonged starvation, the binding of USP20 to ULK1 is diminished, leading to autophagy inhibition [43]."
31630678
sparser
"HERC2-mediated regulation of the USP20-ULK1 axis in the HERC2-related disorder."
38570483
sparser
"Under prolonged starvation, the binding of USP20 to ULK1 is diminished, leading to autophagy inhibition [ xref ]."
31630678
sparser
"In a more pathophysiological context, we studied the USP20-ULK1 axis in patient-derived human fibroblasts harboring the mutant HERC2 P594L variant."
38570483
sparser
"Collectively, the results obtained in this murine model correlated with the results observed in human cells and confirmed that HERC2 deficiency is associated with the upregulation of the USP20-ULK1 axis."
38570483
sparser
"Now, we provide novel empirical evidence of a role of HERC2 as an autophagy regulator factor through the USP20-ULK1 axis, with modulation by p38 activation."
38570483
reach
"During prolonged starvation, NEDD4L catalyzes the K27 and K29 ubiquitination on ULK1 [58], whereas the interaction between USP20 and ULK1 is attenuated [43]."
31630678
sparser
"During prolonged starvation, NEDD4L catalyzes the K27 and K29 ubiquitination on ULK1 [ xref ], whereas the interaction between USP20 and ULK1 is attenuated [ xref ]."
31630678
sparser
"This could be caused by the upregulation of the USP20-ULK1 axis."
38570483
sparser
"USP20 can bind, de-ubiquitinate and stabilize ULK1 at a basal level and plays an important role in autophagy initiation."
32887506
reach
"USP20 interacts with and deubiquitinates ULK1, thus protecting it from degradation."
30126257
reach
"However, the interaction between ULK1 and USP20 is weakened upon prolonged induction of autophagy (4 to 8 h), leading to a reduction of the level of ULK1 protein while its ubiquitinated form accumulates [XREF_BIBR]."
30126257
sparser
"Dynamic regulation of the USP20-ULK1 axis may act as a promising target to inhibit autophagy in certain human diseases."
35508480
sparser
"In prolonged starvation, the interaction between USP20 and ULK1 reduces to terminate autophagy [ xref ]."
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