IndraLab

Statements

HERC2 ubiquitinates USP20. 6 / 7
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"To determine whether HERC2 directly ubiquitinates USP20, we performed an in vitro ubiquitination assay."
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"Under unperturbed condition, HERC2 ubiquitinates USP20 and promotes ubiquitination mediated proteasomal degradation of USP20, regulating the status of K48 linked polyubiquitination of CLASPIN and ensuring appropriate protein levels of CLASPIN during the S-phase."
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"To determine whether HERC2 directly ubiquitinates USP20, we performed an in vitro ubiquitination assay."
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ubibrowser
"UbiNet 2.0"
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sparser
"Under unperturbed condition, HERC2 ubiquitinates USP20 and promotes ubiquitination-mediated proteasomal degradation of USP20, regulating the status of K48-linked polyubiquitination of CLASPIN and ensuring appropriate protein levels of CLASPIN during the S-phase."
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reach
"On the other hand, when cells recover from DNA damage, HERC2 mediates USP20 ubiquitination, turning off the DDR signaling."
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